Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Joseph Piraino"'
Autor:
Todd VanArsdale, RoseAnn Ferre, David A. Matthews, Ian Popoff, Marakovits Joseph T, Brion W. Murray, Joseph Piraino, Barbara Mroczkowski, Dong Liming, Stephen Margosiak, Xinjun Hou, M. Catherine Johnson, James Arthur Thomson, Gerrit Los, Eleanor Dagostino, Chuangxing Guo, Samantha Elizabeth Greasley, Hans E. Parge
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5613-5616
Pin1 is a member of the cis-trans peptidyl-prolyl isomerase family with potential anti-cancer therapeutic value. Here we report structure-based de novo design and optimization of novel Pin1 inhibitors. Without a viable lead from internal screenings,
Autor:
Li Haitao, Paderes Genevieve Deguzman, Brion W. Murray, Xinjun Hou, RoseAnn Ferre, Marakovits Joseph T, M. Catherine Johnson, Paul S. Humphries, Samantha Elizabeth Greasley, Eugenia Kraynov, Joseph Piraino, Dong Liming, Eleanor Dagostino, Chuangxing Guo
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(17)
The design of potent Pin1 inhibitors has been challenging because its active site specifically recognizes a phospho-protein epitope. The de novo design of phosphate-based Pin1 inhibitors focusing on the phosphate recognition pocket and the successful
Autor:
Janet M. Trowbridge, Richard L. Gallo, Robert A. Dorschner, Victor Nizet, Vasumati K. Pestonjamasp, Jennifer A. Rudisill, Kenneth H. Huttner, Xavier Lauth, Takaaki Ohtake, Joseph Piraino
Publikováno v:
Nature. 414:454-457
In mammals, several gene families encode peptides with antibacterial activity, such as the beta-defensins and cathelicidins. These peptides are expressed on epithelial surfaces and in neutrophils, and have been proposed to provide a first line of def
Autor:
Ya-Li Deng, Zhang Junhu, Martin Paul Edwards, James G. Christensen, Yang Anle, Lisa C. Guo, Brion W. Murray, Tikhe Jayashree Girish, Kephart Susan Elizabeth, Indrawan James Mcalpine, Marakovits Joseph T, Dong Liming, Li Haitao, Christine Del-Carmen, Tod Smeal, Daniel D. Knighton, Eugenia Kraynov, Paul G. Richardson, Eleanor Dagostino, Chuangxing Guo, Djamal Bouzida, Robert Steven Kania, Joseph Piraino, M. Catherine Johnson, Joseph K. T. Lee
Publikováno v:
Journal of medicinal chemistry. 55(10)
The P21-activated kinases (PAK) are emerging antitumor therapeutic targets. In this paper, we describe the discovery of potent PAK inhibitors guided by structure-based drug design. In addition, the efflux of the pyrrolopyrazole series was effectively
Autor:
Tod Smeal, Karlicek Shannon Marie, Kephart Susan Elizabeth, Jane Lamerdin, Marakovits Joseph T, Eleanor Dagostino, Chuangxing Guo, Joseph Piraino, John Westwick, Michael Zager, Daniel R. Knighton, Simon Bergqvist, Brion W. Murray, James G. Christensen, Cho-Ming Loi, Ricardo Martinez, Cathy Zhang, Eugenia Kraynov, Ian Popoff
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(20)
Despite abundant evidence that aberrant Rho-family GTPase activation contributes to most steps of cancer initiation and progression, there is a dearth of inhibitors of their effectors (e.g., p21-activated kinases). Through high-throughput screening a
Autor:
Joseph K. T. Lee, Tikhe Jayashree Girish, Ya‐Li Deng, Joseph Piraino, Li Haitao, Djamal Bouzida, Eleanor Dagostino, Chuangxing Guo, Zhang Junhu, Hasam Younis, Kephart Susan Elizabeth, Brion W. Murray, Indrawan James Mcalpine, Jamie Christensen, Marakovits Joseph T, Tod Smeal, Eugenia Kraynov, Cho-Ming Loi, Lisa Guo, Dan Knighton, Catherine Johnson, Yang Anle, Dong Liming
Publikováno v:
Molecular Cancer Therapeutics. 8:PR-2
The p21-activated kinase (PAK) family members are key effectors of Rho family GTPases, which act as regulatory switches that control such cellular processes as motility, proliferation, and cell survival. Some members of this family (such as Cdc42) ha