Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Joseph Penzien"'
Autor:
Rose Barham, Thuy Hoang, Jeremy T. Starr, Jennifer A. Young, M. Megan Lemmon, Joseph Penzien, Mark J. Mitton-Fry, Thomas M. Harris, Antonia A. Nikitenko, Brian S. Gerstenberger, Sandra P. McCurdy, Veerabahu Shanmugasundaram, Lisa Mullins, Joel R. Hardink, Jeffrey M. Casavant, Eric S. Marr, Jian Lin, Seungil Han, Joel T. Arcari, John P. Mueller, Brandon P. Schuff, Mark S. Plummer, Craig J. McPherson, Michael D. Huband, Mark C. Noe, Manjinder S. Lall, Richard P. Zaniewski, Chao Li, Matthew Frank Brown, Jianmin Sun, Eric B. McElroy, Andrew P. Tomaras
Publikováno v:
Journal of Medicinal Chemistry. 56:5541-5552
Herein we describe the structure-aided design and synthesis of a series of pyridone-conjugated monobactam analogues with in vitro antibacterial activity against clinically relevant Gram-negative species including Pseudomonas aeruginosa , Klebsiella p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8694e6ad3d6cdb04a7acacaafb875122
https://doi.org/10.1021/jm400560z
https://doi.org/10.1021/jm400560z
Autor:
Lisa Mullins, Daniel P. Uccello, Justin I. Montgomery, Ye Che, John P. O'Donnell, Mark S. Plummer, Joseph A. Abramite, Seung Won Chung, Loren M. Price, Mark C. Noe, Laura A. McAllister, Rose Barham, Mark J. Mitton-Fry, Andrew P. Tomaras, Usa Reilly, Matthew Frank Brown, Jinshan M. Chen, Joseph Penzien, Carol A. Menard, Veerabahu Shanmugasundaram, Robert M. Oliver
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6832-6838
The synthesis and antibacterial activity of heterocyclic methylsulfone hydroxamates is presented. Compounds in this series are potent inhibitors of the LpxC enzyme, a key enzyme involved in the production of lipopolysaccharide (LPS) found in the oute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5698632622184881fc9d9e040335da17
https://doi.org/10.1016/j.bmcl.2012.09.058
https://doi.org/10.1016/j.bmcl.2012.09.058
Autor:
Hongying Gao, Jennifer A. Young, Joel R. Hardink, Veerabahu Shanmugasundaram, Steven M. Finegan, David Pattavina, Joel T. Arcari, Jian Lin, Jianmin Sun, Mark J. Mitton-Fry, Thuy Hoang, Matthew Frank Brown, Hud Lawrence Risley, Rebecca Irvine, Mark Edward Flanagan, Brandon P. Schuff, Seungil Han, Manjinder S. Lall, Brian S. Gerstenberger, Mark Niosi, Thomas M. Harris, Michael D. Huband, Chao Li, Lisa Mullins, Sandra P. McCurdy, M. Megan Lemmon, John P. Mueller, Jennifer Winton, Jeffrey M. Casavant, Mark S. Plummer, Mark C. Noe, Joseph Penzien, Jeremy T. Starr, David M. George
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5989-5994
Novel siderophore-linked monobactams with in vitro and in vivo anti-microbial activity against MDR Gram-negative pathogens are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f098206894352a3aaa930374bca05a
https://doi.org/10.1016/j.bmcl.2012.07.005
https://doi.org/10.1016/j.bmcl.2012.07.005
Autor:
Joseph Penzien
Publikováno v:
Structural Engineering and Mechanics. 17:281-290
A review of current procedures being used in engineering practice to analyze the response of structure/foundation systems subjected separately to different types of dynamic excitation, such as earthquake, sea-wave action, wind, or moving wheel loads,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af4cb82e25eb2521a69c06ad449000aa
https://doi.org/10.12989/sem.2004.17.3_4.281
https://doi.org/10.12989/sem.2004.17.3_4.281
Autor:
Joseph Penzien
Publikováno v:
Earthquake Spectra. 17:1-34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec8f15e2da5ec0e1ec3f67220c4194fd
https://doi.org/10.1193/1.1586164
https://doi.org/10.1193/1.1586164
Autor:
Joseph Penzien
Publikováno v:
Earthquake Engineering & Structural Dynamics. 29:683-691
An analytical procedure is presented for evaluating the racking deformation of rectangular and circular tunnel linings caused by soil–structure interaction during a seismic event. The procedure, as applied to rectangular linings, is supplementary t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa15833a3c232c115b7bd73b00a47064
https://doi.org/10.1002/(sici)1096-9845(200005)29:5<683::aid-eqe932>3.0.co
https://doi.org/10.1002/(sici)1096-9845(200005)29:5<683::aid-eqe932>3.0.co
Autor:
Ching L. Wu, Joseph Penzien
Publikováno v:
Earthquake Engineering & Structural Dynamics. 27:283-300
An analytical procedure is presented for evaluating the stresses in linings of bored tunnels caused by kinematic soil–lining interaction. Three cases of plane–strain interaction are treated as produced by (1) relaxation of in situ soil stresses n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93c0f5393882e531f34509d98df7667c
https://doi.org/10.1002/(sici)1096-9845(199803)27:3<283::aid-eqe732>3.0.co
https://doi.org/10.1002/(sici)1096-9845(199803)27:3<283::aid-eqe732>3.0.co
Autor:
Joseph Penzien
Publikováno v:
Earthquake Engineering & Structural Dynamics. 26:849-858
Presented herein is an analytical procedure for evaluating the separation distance required between two buildings to prevent pounding during strong earthquakes. The procedure is based on equivalent linearization of non-linear hysteretic behaviour and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0da16d891534d13f9f4f210ba65e8de8
https://doi.org/10.1002/(sici)1096-9845(199708)26:8<849::aid-eqe680>3.0.co
https://doi.org/10.1002/(sici)1096-9845(199708)26:8<849::aid-eqe680>3.0.co
Publikováno v:
Earthquake Engineering & Structural Dynamics. 23:433-445
An alternative method is presented for generating uniform-hazard response spectra making use of a seismic hazard curve expressing annual probability of exceedance as a function of Peak Ground Acceleration (PGA), a set of normalized (PGA = 1g) mean re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42868b175aef8d9060e782b3bb43daf6
https://doi.org/10.1002/eqe.4290230406
https://doi.org/10.1002/eqe.4290230406
Autor:
Matthew David Doroski, Joel T. Arcari, Mark S. Plummer, Andrea Marra, Thomas M. Harris, Justin I. Montgomery, Usa Reilly, Carol A. Menard, Michael D. Huband, Anthony Marfat, Jinshan Michael Chen, Christy Thoma, Karen L. Leach, John P. O'Donnell, Seung Won Chung, Loren M. Price, Joseph A. Abramite, Charlene R. Desbonnet, Eric B. McElroy, Veerabahu Shanmugasundaram, Michael Melnick, Shenping Liu, Matthew Frank Brown, Mark C. Noe, Joseph S. Warmus, Juntyma J. Engtrakul, Daniel P. Uccello, Donn G. Wishka, Robert M. Oliver, Rose Barham, Joseph Penzien, Jonathan L. Doty, John D. Knafels, Ye Che, Lisa Mullins, Elizabeth M. Collantes
Publikováno v:
Journal of medicinal chemistry. 55(2)
In this paper, we present the synthesis and SAR as well as selectivity, pharmacokinetic, and infection model data for representative analogues of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid 1a.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdcf3eac90ca18e20f4de1258188335d
https://pubmed.ncbi.nlm.nih.gov/22175825
https://pubmed.ncbi.nlm.nih.gov/22175825