Bordetella hinzii Meningitis in Patient with History of Kidney Transplant, Virginia, USA

Autor: Joseph Pechacek, Jillian Raybould, Megan Morales

Publikováno v: Emerging Infectious Diseases, Vol 27, Iss 9, Pp 2459-2461 (2021)

A patient in Virginia, USA, who had previously undergone multiple kidney transplantations showed signs of Bordetella hinzii bacteremia and meningitis. This emerging pathogen has been increasingly identified as a clinically significant pathogen in imm

Externí odkaz: https://doaj.org/article/85c2e975daec4fd082aab4097d929338

Interferon Alpha Treatment of Patients with Impaired Interferon Gamma Signaling

Autor: Alexandra F. Freeman, Hannelore I. Bax, Reginald J. Claypool, Kenneth N. Olivier, Timothy Jancel, Li Ding, Christa S. Zerbe, Joseph Pechacek, Lisa A. Barnhart, B.E. Marciano, Amy P. Hsu, Christine Spalding, Elizabeth P. Sampaio, Ervand Kristosturyan, Cathleen Frein, Victoria L. Anderson, Lisa Boris, S.M. Holland

Publikováno v: Journal of Clinical Immunology, 33(5), 991-1001. Springer New York

Patients with deficiency in the interferon gamma receptor (IFN-gamma R) are unable to respond properly to IFN-gamma and develop severe infections with nontuberculous mycobacteria (NTM). IFN-gamma and IFN-alpha are known to signal through STAT1 and ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fbf205a839d57b5a67467ffd0b396e
https://pure.eur.nl/en/publications/be0f3f75-7893-43c0-851a-35a1c180988d

Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis

Autor: Michael U. Shiloh, Christa S. Zerbe, Susan E. Hoover, Li Ding, Douglas B. Kuhns, Vivek Ramarathnam, Christine Spalding, Mohammed A. Sadat, David E. Greenberg, Joseph Pechacek, Michelle L. Paulson, Elizabeth P. Sampaio, Lindsey B. Rosen, Dalton L. Dias, Daniel Serra de Carvalho, Gulbu Uzel, Donald C. Vinh, Brendan De Marco, Hannelore I. Bax, Michael Alvares, Joshua D. Milner, Amy P. Hsu, Henry E. Wiley, Ileana Moreira, Daniel Johnson, Sarah K. Browne, Shrimati Datta, John N. Galgiani, Jason Gillman, Maria Teresa De La Morena, Sergio D. Rosenzweig, Steven M. Holland, Debra A. Long Priel, Prabha Chandrasekaran, Liliana Bezrodnik

Publikováno v: Journal of Allergy and Clinical Immunology, 131(6), 1624-+. Mosby Inc.
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Background: Impaired signaling in the IFN-g/IL-12 pathway causes susceptibility to severe disseminated infections with mycobacteria and dimorphic yeasts. Dominant gain-of-function mutations in signal transducer and activator of transcription 1 (STAT1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d7615e0d7f330060597a2f10b78730
https://pure.eur.nl/en/publications/fe2bbf24-f196-4105-bd6a-935fe2f5ebed

Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation–polyendocrinopathy–enteropathy–X-linked–like syndrome

Autor: Sara Ciullini Mannurita, Eleonora Gambineri, Mary J. Hackett, Dat Q. Tran, Amy P. Hsu, Francisco A. Bonilla, Joseph Pechacek, Troy R. Torgerson, Morna J. Dorsey, Monica G. Lawrence, Erin Janssen, Anahita Agharahimi, Gulbu Uzel, Jae-Joon Yim, Joshua D. Milner, Ahmed M. Gharib, Sarah K. Browne, Steven M. Holland, Prabha Chandrasekaran, James W. Verbsky, Richard J. Noel, Alexandra F. Freeman, Elizabeth P. Sampaio

Publikováno v: The Journal of allergy and clinical immunology, vol 131, iss 6

Background Mutations in signal transducer and activator of transcription (STAT) 1 cause a broad spectrum of disease, ranging from severe viral and bacterial infections (amorphic alleles) to mild disseminated mycobacterial disease (hypomorphic alleles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fa5e33606bb898f2c645ac742b518d
https://doi.org/10.1016/j.jaci.2012.11.054