Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Joseph P. Yevich"'
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 45:987-994
The synthesis of two 125I-labeled trisubstituted aromatic melatonergic agents is reported. N-[[2-[125I]iodo-5-methoxyphenyl)-1R, 2R-cyclopropyl]methyl] butanamide was prepared from the corresponding thallium salt and Na 125I in radiochemical yields o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::334384c4fc8aaef75fa87488316b06aa
https://doi.org/10.1002/jlcr.618
https://doi.org/10.1002/jlcr.618
Autor:
Joseph P. Yevich, Frank D. Yocca
Publikováno v:
Current Medicinal Chemistry. 4:295-312
The discovery and development of the 5-HT1810 agonist sumatriptan for alleviating migraine pain has been an important advance in the field of modern headache treatment and research. This important therapeutic advance is not without it's shortcomings.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c23ef2dd59212d8fc311978092442215
https://doi.org/10.2174/0929867304666220313122326
https://doi.org/10.2174/0929867304666220313122326
Autor:
Joseph P Yevich
Publikováno v:
Expert Opinion on Therapeutic Patents. 7:511-521
The patent literature pertaining to agents for the treatment of migraine headache and related disorders has been reviewed for the period of July 1, 1995 to December 31, 1996. Included are patents on serotonergic agents, such as 5-hydroxytryptamine 1D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bb9b01a2930dea85fa8d003d8ee0ac8
https://doi.org/10.1517/13543776.7.5.511
https://doi.org/10.1517/13543776.7.5.511
Autor:
Joseph P Yevich
Publikováno v:
Expert Opinion on Therapeutic Patents. 5:1077-1086
The patent literature pertaining to agents for the treatment of migraine headache and related disorders has been reviewed for the period of July 1, 1994 to June 30, 1995. Included are patents on serotonergic agents, i.e. 5-HT1D agonists, 5-HT2 recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dfcfaddafdec7063dd67cb9c39137c0
https://doi.org/10.1517/13543776.5.10.1077
https://doi.org/10.1517/13543776.5.10.1077
Autor:
Hiromi Morimoto, Lidia Doweykos, Bradley C. Pearce, Joseph P Yevich, Keith D. Combrink, Philip G. Williams, Douglas D. Dischino
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 36:789-794
The title compound was prepared by the LiAIT 4 reduction of 5-fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)- 1-piperazinyl]-3-oxopropyl]- 1H-indole. The radiochemical purity of the product was 98.9% and the specific activity was calculated as 53.0 Ci/mmol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad446697ac8f0fe76508ea0757cef0b4
https://doi.org/10.1002/jlcr.2580360810
https://doi.org/10.1002/jlcr.2580360810
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1941-1946
A number of N-substituted 1-(5-fluoro-2-pyrimidinyl)piperazine derivatives were prepared and evaluated for binding to sigma and serotonin 5-HT 1A and 5-HT 2 receptor subtypes as well as for their protection against nitrogen anoxia-induced lethality i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5dce7b757efa93a554522bcf446b95c
https://doi.org/10.1016/s0960-894x(01)80539-4
https://doi.org/10.1016/s0960-894x(01)80539-4
Publikováno v:
ChemInform. 26
A number of N-substituted 1-(5-fluoro-2-pyrimidinyl)piperazine derivatives were prepared and evaluated for binding to sigma and serotonin 5-HT 1A and 5-HT 2 receptor subtypes as well as for their protection against nitrogen anoxia-induced lethality i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72977febe0afae89607e4c4fc43e080e
https://doi.org/10.1002/chin.199509145
https://doi.org/10.1002/chin.199509145
Autor:
Edith Bernstein, Davis L Temple, Michael S. Eison, Duncan P. Taylor, Frank D. Yocca, Walter G Lobeck, Joseph P Yevich, Pierre Dextraze, James Stewart New
Publikováno v:
Journal of Medicinal Chemistry. 35:4516-4525
A series of 1-(pyrimidin-2-yl)piperazine derivatives were prepared and evaluated in receptor binding assays and in in vivo behavioral paradigms as potential atypical antipsychotic agents. Compound 16 (BMS 181100 (formerly BMY 14802)) emerged as the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4ce6ca0ead54e81473158a3c76304c
https://doi.org/10.1021/jm00102a002
https://doi.org/10.1021/jm00102a002
Publikováno v:
Kent and Riegel’s Handbook of Industrial Chemistry and Biotechnology ISBN: 9780387278421
This chapter discusses the role of chemistry within the pharmaceutical industry [1–3]. Although the focus is upon the industry within the United States, much of the discussion is equally relevant to pharmaceutical companies based in other first-wor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d97a8eb3f19753caf39842874d98bdf
https://doi.org/10.1007/978-0-387-27843-8_11
https://doi.org/10.1007/978-0-387-27843-8_11
Autor:
Lawrence G. Iben, Joseph P Yevich, Qi Gao, Michael F. Dee, Arlene Stark, Ronald J. Mattson, John R. Torrente, Kenneth M. Boy
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(17)
Conformationally constrained aryl cyclohexanes and cyclohexenes based on aryl cyclohexanols 1 were prepared. Locking the aryl ring in plane with the cyclohexane moiety provided potent SSRIs 3. Conversely, fixing the aryl ring perpendicular to the cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7d615be4af78eb7acc7003345aec80
https://pubmed.ncbi.nlm.nih.gov/15357973
https://pubmed.ncbi.nlm.nih.gov/15357973