Výsledky vyhledávání - "Joseph P. Sterk"

Differential effects of heptanoate and hexanoate on myocardial citric acid cycle intermediates following ischemia-reperfusion

Autor: Wenjun Z. Martini, Hazel Huang, Isidore C. Okere, Tracy A. McElfresh, Margaret P. Chandler, Henri Brunengraber, William C. Stanley, Daniel Z. Brunengraber, Joseph P. Sterk

Publikováno v: Journal of Applied Physiology. 100:76-82

In the normal heart, there is loss of citric acid cycle (CAC) intermediates that is matched by the entry of intermediates from outside the cycle, a process termed anaplerosis. Previous in vitro studies suggest that supplementation with anaplerotic su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a577f657de5c16d3feee38611582c2
https://doi.org/10.1152/japplphysiol.00255.2005

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Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demand-induced ischemia

Autor: Eric E. Morgan, Isidore C. Okere, Hazel Huang, Gary D. Lopaschuk, William C. Stanley, Jason R.B. Dyck, Joseph P. Sterk, Tracy A. McElfresh, Jie-Fei Cheng, Margaret P. Chandler

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 289:H2304-H2309

The rate of cardiac fatty acid oxidation is regulated by the activity of carnitine palmitoyltransferase-I (CPT-I), which is inhibited by malonyl-CoA. We tested the hypothesis that the activity of the enzyme responsible for malonyl-CoA degradation, ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3155166fc25730eb048a91a4b9a8a3f7
https://doi.org/10.1152/ajpheart.00599.2005

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Regulation of pyruvate dehydrogenase activity and citric acid cycle intermediates during high cardiac power generation

Autor: Hazel Huang, Daniel Z. Brunengraber, William C. Stanley, Naveen Sharma, Kristen L. King, Tracy A. McElfresh, Isidore C. Okere, Joseph P. Sterk, Margaret P. Chandler

Publikováno v: The Journal of Physiology. 562:593-603

A high rate of cardiac work increases citric acid cycle (CAC) turnover and flux through pyruvate dehydrogenase (PDH); however, the mechanisms for these effects are poorly understood. We tested the hypotheses that an increase in cardiac energy expendi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a37af5ed3201ce3253993899a5694f16
https://doi.org/10.1113/jphysiol.2004.075713

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Effect of hyperglycemia and fatty acid oxidation inhibition during aerobic conditions and demand-induced ischemia

Autor: Pedro N. Chavez, William C. Stanley, Margaret P. Chandler, Joseph P. Sterk, Tracy A. McElfresh, Hazel Huang

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 284:H1521-H1527

Metabolic interventions improve performance during demand-induced ischemia by reducing myocardial lactate production and improving regional systolic function. We tested the hypotheses that 1) stimulation of glycolysis would increase lactate productio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11efa347064218e6c37df89d0888fa94
https://doi.org/10.1152/ajpheart.00974.2002

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Dissertation/ Thesis

Assessing the impact of tumor evolution on oncology drug development and commercialization

Autor: Sterk, Joseph P. (Sterk, Joseph Phillip)

Thesis (S.M.)--Harvard-MIT Division of Health Sciences and Technology, 2011.
Vita. Cataloged from PDF version of thesis.
Includes bibliographical references (p. 91-97).
This thesis investigates the commercial viability of developing an

Externí odkaz: http://hdl.handle.net/1721.1/65523