Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Joseph P. Simeone"'
Autor:
Mitree M. Ponpipom, Robert L. Bugianesi, Joseph P. Simeone, Ranjit C. Desai, Mark T. Goulet, Mark S Levorse
Publikováno v:
Tetrahedron Letters. 42:6459-6461
The stereospecific formation of 2-aryl-β-methyl tryptamine derivatives 15 and 16 from chiral 4-chloro-1-(3,5-dimethylphenyl)-3-methylbutanones is described. These intermediates were further manipulated into the GnRH antagonists 1b and 1c in five ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab741a2fc21f96354e4e653cc776fb02
https://doi.org/10.1016/s0040-4039(01)01288-6
https://doi.org/10.1016/s0040-4039(01)01288-6
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals.
Carbon-14 labeled sodium formate was utilized for the preparation of a radiolabeled tracer to support the development of a Maxi-K channel blocker. Key to the process was a palladium-catalyzed hydroxycarbonylation of a bromoarene for installation of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce47fc89309c83ab861b6b081f8f77a3
https://doi.org/10.1002/jlcr.1755
https://doi.org/10.1002/jlcr.1755
Autor:
Herb G. Bull, Margarita Garcia-Calvo, Peter Lin, JeanMarie Lisnock, Matthew P. Braun, Dennis C. Dean, Joseph P. Simeone, Robert J. DeVita, Joseph F. Leone
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(17)
During our effort to design a receptor binding assay to aid in the elucidation of the molecular mechanism of ezetimibe, we prepared a sulfur-35 containing radioligand which exhibits improved potency over the glucuronide conjugate of ezetimibe in both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0441d400751808d2073c80717a642eb1
https://pubmed.ncbi.nlm.nih.gov/19631535
https://pubmed.ncbi.nlm.nih.gov/19631535
Autor:
Joseph P. Simeone, John R. Sowa
Publikováno v:
ChemInform. 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fdcf683f7a5d78822f7832bacf0cc5d
https://doi.org/10.1002/chin.200814100
https://doi.org/10.1002/chin.200814100
Autor:
John Mathew, Christine M. Brown, Narindar N. Girotra, Andrew S. Misura, Michael H. Fisher, Joseph P. Simeone, Anne Gurnett, Gui-Bai Liang, Linda Chang, Xiaoxia Qian, Dennis M. Schmatz, Tamas Tamas, Robert L. Bugianesi, Mitree M. Ponpipom, Paula M. Dulski, Rattray Sandra J, Samantha Samaras, Matthew J. Wyvratt, Tesfaye Biftu, Tami Crumley, Terence Murphy, Penny Sue Leavitt, Paul A. Liberator, Dennis Feng, Don Thompson
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(13)
Several analogs of 2,3-diaryl pyrroles were synthesized and evaluated as inhibitors of Eimeria tenella cGMP-dependent protein kinase and in in vivo anticoccidial assays. A 4-fluorophenyl group enhances both in vitro and in vivo activities. The most p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a38d3040b061b8719c969b789479b0d
https://pubmed.ncbi.nlm.nih.gov/15922595
https://pubmed.ncbi.nlm.nih.gov/15922595
Autor:
Joseph P. Simeone, et al. et al.
Publikováno v:
ChemInform. 34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c11814379ddab37fcbf49dc2b1f97505
https://doi.org/10.1002/chin.200310143
https://doi.org/10.1002/chin.200310143
Autor:
Robert Brinkman, Stuart Hayden, Jodie Brice, Joseph P. Simeone, Jason Kodah, Amanda Villoresi, John Sowa
Publikováno v:
Catalysis of Organic Reactions ISBN: 9780824741327
Catalysis of Organic Reactions
Catalysis of Organic Reactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1debe48cd74825d0d0f708fcae190e29
https://doi.org/10.1201/9780203911013.ch30
https://doi.org/10.1201/9780203911013.ch30
Autor:
An-Hua Mao, Yi Tien Yang, Rena Ning Ren, Mitree M. Ponpipom, Stella H. Vincent, Jisong Cui, Joel B. Yudkovitz, Robert L. Bugianesi, George R. Mount, Mellissa Creighton, Kang Cheng, Joseph P. Simeone, Jane-Ling Lo, Mark T. Goulet
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(22)
The synthesis of a number of indole GnRH antagonists is described. Oxidation of the pyridine ring nitrogen, combined with alkylation at the two position, led to a compound with an excellent in vitro activity profile as well as oral bioavailability in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0d9016909508805fb7efc6835dbb42
https://pubmed.ncbi.nlm.nih.gov/12392744
https://pubmed.ncbi.nlm.nih.gov/12392744
Autor:
Jonathan Z. Ho, Allen N. Jones, David J. Schenk, Brian P. Cato, Michael A. Wallace, Steven J. Staskiewicz, Joseph P. Simeone, David G. Melillo
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 50:543-544
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dbeb31bb14c148deb4eff596626638e
https://doi.org/10.1002/jlcr.1255
https://doi.org/10.1002/jlcr.1255
Autor:
Ihor E. Kopka, Philip A. Krieter, Kevin T. Chapman, Dorothy Levorse, Adria Colletti, Charles G. Caldwell, Joseph P. Simeone, Julie M. Olszewski, Malcolm MacCoss, Denise M. Visco, Frank Shen, Mitree M. Ponpipom, Joseph W. Becker, Thomas J. Lanza, Joseph McDonnell, Narindar N. Girotra, Melinda G. Axel, C. A. Saphos, William K. Hagmann, Robert L. Bugianesi, Richard K. Harrison, Craig K. Esser, Amy J. Christen, Vernon L. Moore, Karen Owens, Lisa M. Niedzwiecki, Alice I. Marcy, Philippe L. Durette
Publikováno v:
Journal of medicinal chemistry. 40(6)
Carboxyalkyl peptides containing a biphenylylethyl group at the P1' position were found to be potent inhibitors of stromelysin-1 (MMP-3) and gelatinase A (MMP-2), in the range of 10-50 nM, but poor inhibitors of collagenase (MMP-1). Combination of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c225eff03f14dd3bda887be16d0152aa
https://pubmed.ncbi.nlm.nih.gov/9083493
https://pubmed.ncbi.nlm.nih.gov/9083493