Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Joseph P. Lyssikatos"'
Publikováno v:
HemaSphere, Vol 7, p e32603d4 (2023)
Externí odkaz:
https://doaj.org/article/81c89a7a816d4d9688512d7264ac3a7a
Autor:
Monette Aujay, Amanda J. Broad, Stefan D. Gross, Li Ren, Joseph P. Lyssikatos, Samuel Kintz, Qi Wang, Helen Collins
Publikováno v:
Cancer Research. 83:4019-4019
Mutation or amplification of the human epidermal growth factor receptor 2 (HER2) gene has been identified in numerous solid tumor types, including non-small cell lung cancer (NSCLC), breast, and colorectal cancer. These genetic alterations are believ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70c5fb002d8b5f35a54e8ff8449566be
https://doi.org/10.1158/1538-7445.am2023-4019
https://doi.org/10.1158/1538-7445.am2023-4019
Autor:
Stefan D Gross, Christopher A. Eide, Michael R Burkard, Anna Reister Schultz, Monette A Aujay, Samuel Kintz, Brian J. Druker, Joseph P Lyssikatos
Publikováno v:
Blood. 140:3095-3096
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86db53347e3725aa72668b1c082fd869
https://doi.org/10.1182/blood-2022-162700
https://doi.org/10.1182/blood-2022-162700
Autor:
Bin Ma, Urjana Poreci, Luisette Delva, Fengmei Zhang, Hao Tang, Tonika Bohnert, Patricia Schroeder, Richard Grater, Sudarshan Kapadnis, Kris King, Michael Mingueneau, Marc Hoemberger, Evelyne Polack, Brian T. Hopkins, Prince Robin, Chris Rowbottom, Robert Meissner, Eris Bame, Joseph C Santoro, Paramasivam Murugan, Allie M Roach, Claire M. Metrick, Kevin L. Otipoby, Eric Tien, Josh Johnson, Douglas Donaldson, Joseph P. Lyssikatos, Doug Burdette, Tom Magee, Carrie Boiselle, Chungang Gu, Mukesh Lulla, Bekim Bajrami, Jeremy C. Burns, Cheryl Black, Marx Isaac
Publikováno v:
Journal of medicinal chemistry. 65(2)
Multiple Sclerosis is a chronic autoimmune neurodegenerative disorder of the central nervous system (CNS) that is characterized by inflammation, demyelination, and axonal injury leading to permeant disability. In the early stage of MS, inflammation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73da50c6f550d3e41002d416b5cebb6
https://pubmed.ncbi.nlm.nih.gov/34734694
https://pubmed.ncbi.nlm.nih.gov/34734694
Autor:
Xingrong Liu, Nico Ghilardi, Simon Charles Goodacre, Michael Siu, Jim Nonomiya, G. Buckley, Adam R. Johnson, Yun-Xing Cheng, F.A. Romero, Nick Ray, Rohan Mendonca, C. Robinson, Yuen Po-Wai, Jane R. Kenny, Marya Liimatta, Terry Kellar, Mark Zak, Gary Salmon, J. Lloyd, D.G. Brown, Neville James Mclean, Joseph P. Lyssikatos, Emily J. Hanan, Patrick J. Lupardus, Pawan Bir Kohli, Christopher A. Hurley, Guiling Zhao, Paul Gibbons, Peter H. Crackett
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1522-1531
Disruption of interleukin-13 (IL-13) signaling with large molecule antibody therapies has shown promise in diseases of allergic inflammation. Given that IL-13 recruits several members of the Janus Kinase family (JAK1, JAK2, and TYK2) to its receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e867a785065ce94ed8447c01ad10c0
https://doi.org/10.1016/j.bmcl.2019.04.008
https://doi.org/10.1016/j.bmcl.2019.04.008
Autor:
Julia Gavrilyuk, Amy Laysang, Magda K. Holda, Robert Tchelepi, Zachary Swinney, Christina O. Lee, James W. Purcell, Dong Jun Lee, Marybeth A. Pysz, Samuel A. Williams, Baiwei Lin, Joseph Sandoval, Omar Hamdy, Joseph P. Lyssikatos, Vikram Natwarsinhji Sisodiya, Amanda M. Valdiosera, Hetal Sarvaiya, Monette Aujay, Christine Gu, Dane Holte
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(24)
PNU-159682 is a highly potent secondary metabolite of nemorubicin belonging to the anthracycline class of natural products. Due to its extremely high potency and only partially understood mechanism of action, it was deemed an interesting starting poi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b2e2d2258e2bb8433582289cec39182
https://pubmed.ncbi.nlm.nih.gov/33127540
https://pubmed.ncbi.nlm.nih.gov/33127540
Autor:
Huiyong Hu, Steven Do, Aleksandr Kolesnikov, Jason Drummond, Jae H. Chang, Jeremy Murray, Heidi J.A. Wallweber, Leanne Ross, Vivienne Allen, Mizio Matteucci, Cameron L. Noland, Justin Ly, Eric Fan, Alastair James Hodges, Andrew Sharpe, Allen J. Ebens, Craig Rouse, Eric Harstad, Joseph P. Lyssikatos, David John Nash, Minghua Sun, Veerendra Munugalavadla, Vickie Tsui, Po-Chang Chiang, Shang-Fan Yu, William Kofie, John Moffat, Wesley Blackaby, Grace Ka Yan Chan, Dionysos Slaga, Wei Jia, Coura Diène, Geoff Del Rosario, Xiaojing Wang
Publikováno v:
Journal of medicinal chemistry. 62(4)
Pim kinases have been targets of interest for a number of therapeutic areas. Evidence of durable single-agent efficacy in human clinical trials validated Pim kinase inhibition as a promising therapeutic approach for multiple myeloma patients. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03fefbd10121090f474d5aedda3f58b0
https://pubmed.ncbi.nlm.nih.gov/30715878
https://pubmed.ncbi.nlm.nih.gov/30715878
Autor:
Joseph P. Lyssikatos, Douglas Marcotte, Christine Lukacs, Mia Rushe, Kevin Little, Robert M. Arduini, Andrea Bertolotti-Ciarlet, Xin Zhili, Tricia L. May-Dracka, Murugan Paramasivam, Thomas A. Patterson, Govinda Bhisetti, Timothy D. McKee, Kateri Atkins, Michael Cullivan, Thomas Hesson, Laura Silvian, Xin E. Sun
Publikováno v:
Protein Science. 26:152-162
Germinal-center kinase-like kinase (GLK, Map4k3), a GCK-I family kinase, plays multiple roles in regulating apoptosis, amino acid sensing, and immune signaling. We describe here the crystal structure of an activation loop mutant of GLK kinase domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96eef719619818bd5871569040ff4d1d
https://doi.org/10.1002/pro.3062
https://doi.org/10.1002/pro.3062
Autor:
Rebecca M. Reese, Desiree Amm, Justin Ly, Aleksandr Kolesnikov, Christine E. Brotherton-Pleiss, Steven Do, Daniel G. Shore, David H. Hackos, Vishal Verma, Matthew Volgraf, Lesley J. Murray, Xiaofeng Xu, Guosheng Wu, Aijun Lu, Jun Chen, Baihua Hu, Martin E. Dahl, Huifen Chen, Yuen Po-Wai, Elisia Villemure, Yamin Zhang, Joseph P. Lyssikatos, Yong Chen, Brian Safina, Lan Wang, Anthony Estrada, Wienke Lange, Shawn David Erickson, Shannon D. Shields, Suzanne Tay
Publikováno v:
Journal of medicinal chemistry. 61(8)
Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed in sensory neurons where it functions as an irritant sensor for a plethora of electrophilic compounds and is implicated in pain, itch, and respiratory disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1efb169a4638458b259af0587c1a4d5
https://pubmed.ncbi.nlm.nih.gov/29590749
https://pubmed.ncbi.nlm.nih.gov/29590749
Autor:
Leanna Staben, Klaus Koefoed, Helga Raab, Cecile Chalouni, Yana Khalfin, Laura DePalatis, Kelly M. Loyet, Thomas H. Pillow, Min Xu, Byoung-Chul Lee, Peter S. Andersen, Emile Plise, Janice Kim, Elizabeth Luis, Martine Darwish, Rina Fong, Man-Wah Tan, Eric J. Brown, Patrick J. Lupardus, J. Hiroshi Morisaki, Summer Park, Sophie M. Lehar, Donghong Yan, Richard Vandlen, Joseph P. Lyssikatos, Magnus Strandh, Wouter L. W. Hazenbos, John A. Flygare, Sanjeev Mariathasan, Kimberly Kajihara, Hilda Hernandez, Jonathan Cheong
Publikováno v:
Nature. 527:323-328
Staphylococcus aureus is considered to be an extracellular pathogen. However, survival of S. aureus within host cells may provide a reservoir relatively protected from antibiotics, thus enabling long-term colonization of the host and explaining clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83140a68bee3ff5327a432f58cf3a1f8
https://doi.org/10.1038/nature16057
https://doi.org/10.1038/nature16057