Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Joseph P. Horrigan"'
Autor:
Melissa Kennedy, Larry Glass, Daniel G. Glaze, Steve Kaminsky, Alan K. Percy, Jeffrey L. Neul, Nancy E. Jones, Daniela Tropea, Joseph P. Horrigan, Paige Nues, Kathie M. Bishop, James M. Youakim
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Rett syndrome (RTT) is rare neurodevelopmental disorder caused by mutations in the MECP2 gene that encodes methyl-CpG-binding protein 2 (MeCP2), a DNA-binding protein with roles in epigenetic regulation of gene expression. Functional loss of MeCP2 re
Externí odkaz:
https://doaj.org/article/b550d1b8d2c644c1ba103860350a3bb0
Autor:
Sean Oosterholt, Oscar Della Pasqua, Tiago Gomes, Stuart Evans, Mike Snape, Hanns Lochmüller, Nikoletta Nikolenko, Joseph P. Horrigan, Alison McMorn, Alex Yaroshinsky
Publikováno v:
Pediatric Neurology. 112:84-93
GSK3β is an intracellular regulatory kinase that is dysregulated in multiple tissues in type 1 myotonic dystrophy, a rare neuromuscular disorder that manifests at any age. AMO-02 (tideglusib) inhibits GSK3β activity in preclinical models of type 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282a4c2a5b9c06c41553fab7a003353b
https://doi.org/10.1016/j.pediatrneurol.2020.08.001
https://doi.org/10.1016/j.pediatrneurol.2020.08.001
Autor:
Elizabeth Berry-Kravis, Joseph P. Horrigan, Nicole Tartaglia, Randi Hagerman, Alexander Kolevzon, Craig A. Erickson, Shivkumar Hatti, Mike Snape, Alex Yaroshinsky, George Stoms, Larry Glass, Nancy E. Jones, Kevin Sanders, Jean Frazier, Thomas Challman, Jeffrey Innis, Bryan King, Joseph Cubells, Jeannie Visootsak, Steven Skinner, Dianne Treadwell-Deering, Sherry Sellers Vinson, Howard Needelman
Publikováno v:
Pediatric neurology. 110
We analyze the safety and tolerability of trofinetide and provide a preliminary evaluation of its efficacy in adolescent and adult males with fragile X syndrome.This study was an exploratory, phase 2, multicenter, double-blind, placebo-controlled, pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f4738de28601a3919712ffd01832dd
https://pubmed.ncbi.nlm.nih.gov/32660869
https://pubmed.ncbi.nlm.nih.gov/32660869
Autor:
Amber Salter, Joseph P. Horrigan, Jane B. Lane, Daniel G. Glaze, Steve A. Skinner, Walter E. Kaufmann, Nancy E. Jones, Alan K. Percy, Gary Cutter, Jeffrey L. Neul
Publikováno v:
Journal of Autism and Developmental Disorders. 47:1102-1112
Rett syndrome (RTT) requires total caregiver attention and leads to potential difficulties throughout life. The Caregiver Burden Inventory, designed for Alzheimer disease, was modified to a RTT Caregiver Inventory Assessment (RTT CIA). Reliability an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b84b9a02dfeb41dfaaf8cb7fb9ad53
https://doi.org/10.1007/s10803-017-3034-3
https://doi.org/10.1007/s10803-017-3034-3
Autor:
Nicole Heilbron, Geraldine Dawson, Barbara Waters-Pick, Linmarie Sikich, Maura Sabatos-DeVito, Saritha Vermeer, Allen W. Song, J.H. Baker, Michael Andrew Murias, Kristin Page, Joanne Kurtzberg, Vinod K. Prasad, Samantha Major, Jesse D. Troy, Fred Sanfilippo, Kimberly L. H. Carpenter, Scott N. Compton, Megan Deaver, Jill Howard, Andrzej S. Kosinski, Jessica Sun, Brianna Herold, Joseph P. Horrigan, Ryan A. Simmons, Lauren Franz
Publikováno v:
The Journal of Pediatrics. 222:164-173.e5
Objective To evaluate whether umbilical cord blood (CB) infusion is safe and associated with improved social and communication abilities in children with autism spectrum disorder (ASD). Study design This prospective, randomized, placebo-controlled, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92f378fb4f1af77c8187faf003e60907
https://doi.org/10.1016/j.jpeds.2020.03.011
https://doi.org/10.1016/j.jpeds.2020.03.011
Autor:
Matcheri S. Keshavan, L. Fredrik Jarskog, Cameron S. Carter, Margaret A. Peykamian, Michael F. Green, Larry J. Seidman, Alan Breier, Martin T. Lowy, John G. Csernansky, Jeffrey A. Lieberman, Joshua T. Kantrowitz, Donald C. Goff, Stephen R. Marder, Richard S.E. Keefe, M. Patricia Ball, Robert P. McMahon, Joseph P. Horrigan, Robert W. Buchanan, Marc Laurelle, Paul Maruff, Richard Grove
Publikováno v:
Schizophrenia Research. 164:136-142
This Phase II exploratory study assessed GSK239512, a brain penetrant histamine H₃ receptor antagonist, versus placebo on cognitive impairment in 50 stable outpatients with schizophrenia. Subjects were randomized to placebo or GSK239512 for 7 weeks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf45603c5fc671ab113c8cd5ece30aa5
https://doi.org/10.1016/j.schres.2015.01.041
https://doi.org/10.1016/j.schres.2015.01.041
Autor:
Bernhard Suter, Nancy E. Jones, Jeffrey L. Neul, Joseph P. Horrigan, Thuy Dinh, Arthur A. Beisang, Mike Snape, Alan K. Percy, Evdokia Anagnostou, Daniel G. Glaze, Timothy Feyma
Publikováno v:
Journal of child neurology, vol 30, iss 13
Rett syndrome is a genetically based neurodevelopmental disorder. Although the clinical consequences of Rett syndrome are profound and lifelong, currently no approved drug treatments are available specifically targeted to Rett symptoms. High quality
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55536c5f0ab8b30e211dfe87b5edae9
https://doi.org/10.1177/0883073815579707
https://doi.org/10.1177/0883073815579707
Autor:
Joseph P. Horrigan, Marisela Huerta, Alycia K. Halladay, Lawrence Scahill, Evdokia Anagnostou, Katherine J. Sullivan, Paul P. Wang, Catherine Lord, Nancy E. Jones, Connie Kasari, Dennis W. Choi, Geraldine Dawson
Publikováno v:
Autism. 19:622-636
Social communication impairments are a core deficit in autism spectrum disorder. Social communication deficit is also an early indicator of autism spectrum disorder and a factor in long-term outcomes. Thus, this symptom domain represents a critical t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7e2538915f6e28b31e7b54cd71b6ca
https://doi.org/10.1177/1362361314542955
https://doi.org/10.1177/1362361314542955
Autor:
Andrew P Nicholls, Andreas Mahler, Pradeep J. Nathan, Conn M Harrington, Rebecca L. Boardley, Paul Maruff, Alienor Berges, Joseph P. Horrigan, Richard Grove, Martin T. Lowy, Isabel Jm Beresford
Publikováno v:
Current Alzheimer Research. 11:47-58
Introduction: Histaminergic H 3 receptors may play a role in modulating cholinergic and monoaminergic neurotransmission. This Phase II study evaluated the efficacy and safety of GSK239512, a highly potent, brain penetrant H 3 receptor antagonist as m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3f0f1ccba157b5957343b148751e599
https://doi.org/10.2174/1567205010666131212110148
https://doi.org/10.2174/1567205010666131212110148
Autor:
S. Pirruccello, S. Shackelford, Ole Graff, Sieghart Sopper, Richard Grove, M. Gold, Eva Havrdova, Joseph P. Horrigan
Publikováno v:
European Journal of Neurology. 20:1032-1042
Background and purpose Firategrast is an orally bioavailable alpha4 beta1/alpha4 beta7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS). This could decrease multiple sclerosis (MS) activity, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2106d8ff5cb49f3a0b3f30cb58f0fd
https://doi.org/10.1111/ene.12097
https://doi.org/10.1111/ene.12097