Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Joseph P. Fisher"'
Cerebral perfusion metrics calculated directly from a hypoxia-induced step change in deoxyhemoglobin
Autor:
James Duffin, Ece Su Sayin, Olivia Sobczyk, Julien Poublanc, David J. Mikulis, Joseph A. Fisher
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Resting cerebral perfusion metrics can be calculated from the MRI ΔR2* signal during the first passage of an intravascular bolus of a Gadolinium-based contrast agent (GBCA), or more recently, a transient hypoxia-induced change in the concen
Externí odkaz:
https://doaj.org/article/12568e23cccb48909bbdc57866bedd4b
Autor:
Vittorio Stumpo, Ece Su Sayin, Jacopo Bellomo, Olivia Sobczyk, Christiaan Hendrik Bas van Niftrik, Martina Sebök, Michael Weller, Luca Regli, Zsolt Kulcsár, Athina Pangalu, Andrea Bink, James Duffin, David D. Mikulis, Joseph A. Fisher, Jorn Fierstra
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Background: Transient hypoxia-induced deoxyhemoglobin (dOHb) has recently been shown to represent a comparable contrast to gadolinium-based contrast agents for generating resting perfusion measures in healthy subjects. Here, we investigate the feasib
Externí odkaz:
https://doaj.org/article/5451cc7dece8445ebdfc3670de04d191
Autor:
Martina Sebök, Frank van der Wouden, Cäcilia Mader, Athina Pangalu, Valerie Treyer, Joseph Arnold Fisher, David John Mikulis, Martin Hüllner, Luca Regli, Jorn Fierstra, Christiaan Hendrik Bas van Niftrik
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 24 (2023)
Background Staging of hemodynamic failure (HF) in symptomatic patients with cerebrovascular steno‐occlusive disease is required to assess the risk of ischemic stroke. Since the gold standard positron emission tomography‐based perfusion reserve is
Externí odkaz:
https://doaj.org/article/2c3a0a4288bc4b3fa5ba4dce57340b78
Publikováno v:
Data in Brief, Vol 49, Iss , Pp 109311- (2023)
The use of lattice structure in the Design for Additive Manufacturing (DfAM) engineering practice offers the ability to tailor the properties (and therefore the response) of an engineered component independent of the material and overall geometry. Th
Externí odkaz:
https://doaj.org/article/425960f1ee144434a759561381b4f057
Autor:
Ece Su Sayin, Olivia Sobczyk, Julien Poublanc, David J. Mikulis, Joseph A. Fisher, James Duffin
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Use of contrast in determining hemodynamic measures requires the deconvolution of an arterial input function (AIF) selected over a voxel in the middle cerebral artery to calculate voxel wise perfusion metrics. Transfer function analysis
Externí odkaz:
https://doaj.org/article/7301816458004c009d79cb51b09b77e4
Autor:
Jacob Benjamin Schulman, Ece Su Sayin, Angelica Manalac, Julien Poublanc, Olivia Sobczyk, James Duffin, Joseph A. Fisher, David Mikulis, Kâmil Uludağ
Publikováno v:
Frontiers in Neuroimaging, Vol 2 (2023)
IntroductionDynamic susceptibility contrast (DSC) MRI allows clinicians to determine perfusion parameters in the brain, such as cerebral blood flow, cerebral blood volume, and mean transit time. To enable quantification, susceptibility changes can be
Externí odkaz:
https://doaj.org/article/ce71c70ddd594426a2ccf68897f08e29
Autor:
Alex A. Bhogal, Ece Su Sayin, Julien Poublanc, James Duffin, Joseph A. Fisher, Olivia Sobcyzk, David J. Mikulis
Publikováno v:
NeuroImage, Vol 261, Iss , Pp 119523- (2022)
Cerebral blood arrival and tissue transit times are sensitive measures of the efficiency of tissue perfusion and can provide clinically meaningful information on collateral blood flow status. We exploit the arterial blood oxygen level dependent (BOLD
Externí odkaz:
https://doaj.org/article/a356a5d8dec340f594f0363498ac4fbf
Autor:
Ece Su Sayin, Olivia Sobczyk, Julien Poublanc, David J. Mikulis, Joseph A. Fisher, Kevin H. M. Kuo, James Duffin
Publikováno v:
Physiological Reports, Vol 10, Iss 19, Pp n/a-n/a (2022)
Abstract In patients with sickle cell disease (SCD), the delivery of oxygen to the brain is compromised by anemia, abnormal rheology, and steno‐occlusive vascular disease. Successful compensation depends on an increase in oxygen supply such as that
Externí odkaz:
https://doaj.org/article/86e3a224da09422f91535b9ccb790851
Autor:
Stéphanie Forté, Olivia Sobczyk, Julien Poublanc, James Duffin, Gregory M. T. Hare, Joseph Arnold Fisher, David Mikulis, Kevin H. M. Kuo
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Background: Despite increased cerebral blood flow (CBF), cerebral infarcts occur in patients with sickle cell disease (SCD). This suggests increased CBF does not meet metabolic demand possibly due to compromised cerebral vasodilatory response. Hypoth
Externí odkaz:
https://doaj.org/article/bb7c254fe64c4caba2516b42041575b1
Autor:
Katelyn E. Heimbruch, Joseph B. Fisher, Cary T. Stelloh, Emily Phillips, Michael H. Reimer, Adam J. Wargolet, Alison E. Meyer, Kirthi Pulakanti, Aaron D. Viny, Jessica J. Loppnow, Ross L. Levine, John Anto Pulikkan, Nan Zhu, Sridhar Rao
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Acute myeloid leukemia (AML) is a high-risk malignancy characterized by a diverse spectrum of somatic genetic alterations. The mechanisms by which these mutations contribute to leukemia development and how this informs the use of targeted th
Externí odkaz:
https://doaj.org/article/4bea0347dc9d49beb5298d2cdd70741f