Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Joseph P. Calarco"'
Autor:
Simon M. G. Braun, Jacob G. Kirkland, Emma J. Chory, Dylan Husmann, Joseph P. Calarco, Gerald R. Crabtree
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Understanding the link between epigenetic marks and gene regulation requires the development of new tools to directly manipulate chromatin. Here the authors demonstrate a Cas9-based system to recruit chromatin remodelers to loci of interest, allowing
Externí odkaz:
https://doaj.org/article/ceb7020dd5784ed49c21a33809ac7893
Autor:
Dana S. Neel, Nathaniel A. Hathaway, Oliver Bell, Emma J. Chory, Gerald R. Crabtree, Joseph P Calarco
Summary Recent studies have indicated that nucleosome turnover is rapid, occurring several times per cell cycle. To access the effect of nucleosome turnover on the epigenetic landscape, we investigated H3K79 methylation, which is produced by a single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3271099b55531c8b6f8a9b40cdbfd74
https://europepmc.org/articles/PMC6510544/
https://europepmc.org/articles/PMC6510544/
Autor:
Nathaniel A. Hathaway, Oliver Bell, Dana S. Neel, Joseph P Calarco, Emma J. Chory, Gerald R. Crabtree
Transcription-dependent methylation of histone H3 at lysine 79 (H3K79) is evolutionarily conserved from yeast to mammals, critical for normal development and frequently deregulated by genetic recombination in Mixed Lineage Leukemia. Although this his
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2834095558605f7569202382be4abd06
Autor:
Kairong Cui, Joseph P Calarco, Erik L. Miller, Gerald R. Crabtree, Chiung-Ying Chang, Jason D. Buenrostro, Diana C. Hargreaves, Courtney Hodges, William J. Greenleaf, Keji Zhao, Cigall Kadoch
Publikováno v:
Nature structural & molecular biology, vol 24, iss 4
Nature structural & molecular biology
Nature structural & molecular biology
The resolution and formation of facultative heterochromatin are essential for development, reprogramming, and oncogenesis. The mechanisms underlying these changes are poorly understood owing to the difficulty of studying heterochromatin dynamics and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb390337cd8e44bd01abef0269bef26d
https://escholarship.org/uc/item/1hd474nx
https://escholarship.org/uc/item/1hd474nx
Autor:
Dylan Husmann, Gerald R. Crabtree, Jacob G. Kirkland, Simon M. G. Braun, Joseph P Calarco, Emma J. Chory
Publikováno v:
Nature Communications, Vol. 8, No 1 (2017) P. 560
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Nature Communications
Understanding the causal link between epigenetic marks and gene regulation remains a central question in chromatin biology. To edit the epigenome we developed the FIRE-Cas9 system for rapid and reversible recruitment of endogenous chromatin regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa224da83d4ea48cc3f30d3e09146a5
https://archive-ouverte.unige.ch/unige:154531
https://archive-ouverte.unige.ch/unige:154531
Autor:
Courtney Hodges, Gerald R. Crabtree, Cigall Kadoch, Wai Lim Ku, Keji Zhao, Simon M. G. Braun, Benjamin Z. Stanton, Joseph P Calarco
Publikováno v:
Nature Genetics, Vol. 49, No 2 (2017) pp. 282-288
Trithorax-group genes and mammalian homologues, including BAF (mSWI/SNF) complexes, have been known for nearly 30 years to oppose Polycomb repressive activity1–5. This opposition underlies the tumor-suppression role of BAF3,5–7 and is expected to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609d70c35aba2d22b26b21d944f0968d
https://archive-ouverte.unige.ch/unige:154532
https://archive-ouverte.unige.ch/unige:154532
Autor:
Erik L. Miller, Simon M. G. Braun, Gerald R. Crabtree, Emma J. Chory, Cigall Kadoch, Robert T Williams, Joseph P Calarco, Christopher M. Weber, John L. Pulice
Publikováno v:
Nature Genetics, Vol. 49, No 2 (2017) pp. 213-222
Nature genetics
Nature genetics
The opposition between Polycomb repressive complexes (PRCs) and BAF (mSWI/SNF) complexes has a critical role in both development and disease. Mutations in the genes encoding BAF subunits contribute to more than 20% of human malignancies, yet the unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d75515730584b4cfcebecce938e942
https://archive-ouverte.unige.ch/unige:154520
https://archive-ouverte.unige.ch/unige:154520
Autor:
Tetsu Kinoshita, Miyuki Nakamura, Joseph P. Calarco, Thiet Minh Vu, Tetsuya Higashiyama, Daichi Susaki, Pei Qi Lim, Frédéric Berger, Robert A. Martienssen
Publikováno v:
Development. 140:2953-2960
In mammals and plants, parental genomic imprinting restricts the expression of specific loci to one parental allele. Imprinting in mammals relies on sex-dependent de novo deposition of DNA methylation during gametogenesis but a comparable mechanism w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114d25c8b911c68f7909d74b74f2c227
https://doi.org/10.1242/dev.092981
https://doi.org/10.1242/dev.092981
Autor:
Qun Pan, Benjamin J. Blencowe, Todd M. Preuss, John A. Calarco, Joseph P. Calarco, Christopher Lee, Mario Cáceres, Xinshu Xiao, Yi Xing
Publikováno v:
Genes & Development. 21:2963-2975
Alternative splicing is a powerful mechanism affording extensive proteomic and regulatory diversity from a limited repertoire of genes. However, the extent to which alternative splicing has contributed to the evolution of primate species-specific cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858b89c86d60a7a8df855def45f4ffd5
https://doi.org/10.1101/gad.1606907
https://doi.org/10.1101/gad.1606907
Autor:
James P. Fawcett, Joseph P. Calarco, Victoria Aranda, Marissa E. Nolan, Tony Pawson, Senthil K. Muthuswamy, Teresa Haire, Avi Z. Rosenberg
Publikováno v:
Nature Cell Biology. 8:1235-1245
The polarized glandular organization of epithelial cells is frequently lost during development of carcinoma. However, the specific oncogene targets responsible for polarity disruption have not been identified. Here, we demonstrate that activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::761b2cfa9a733e0a48d1c30e7628d987
https://doi.org/10.1038/ncb1485
https://doi.org/10.1038/ncb1485