Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Joseph P. Burkhart"'
Autor:
Michael R. Angelastro, Joseph P. Burkhart, M J Janusz, Chen Tm, Edward W. Huber, Koehl, Baugh Le, S L Durham, Philippe Bey, C M Hare
Publikováno v:
Journal of Medicinal Chemistry. 37:4538-4553
Valylprolylvalyl pentafluoroethyl ketones with different N-protecting groups were evaluated in vitro and in vivo as inhibitors of human neutrophil elastase (HNE). Several of these compounds were found to be orally active in HNE-induced rat and hamste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42ac75d902ff0576990760d71e72cc0
https://doi.org/10.1021/jm00052a013
https://doi.org/10.1021/jm00052a013
Publikováno v:
Journal of Heterocyclic Chemistry. 31:419-423
2,5-Bis-(3,4,5-trimethoxyphenyl)-2-oxazoline (5, MDL 100,270) was desi- gned as a potential plateletactivating factor (PAF) antagonist on the basis of computer modeling comparison studies with known PAF antagonis- ts. An efficient, four-step synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e16c0075446b6a990ce12d14d24f8f5f
https://doi.org/10.1002/jhet.5570310229
https://doi.org/10.1002/jhet.5570310229
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 44:409-420
The design and syntheses of androstenedione derivatives with bridges spanning the 2,19-, 3,19-, 4,19- and 6,19-positions are described. 2,19-Bridged compounds bearing hydroxyl groups on the two-carbon bridge ( 3a and 3b ) were designed as stable carb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf12f50770a9464926bd0ced5089170
https://doi.org/10.1016/0960-0760(93)90244-q
https://doi.org/10.1016/0960-0760(93)90244-q
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b904cbd5b576fcb5a1bbcc149e76d98f
https://doi.org/10.1002/chin.199248266
https://doi.org/10.1002/chin.199248266
Publikováno v:
ChemInform. 26
2,5-Bis-(3,4,5-trimethoxyphenyl)-2-oxazoline (5, MDL 100,270) was desi- gned as a potential plateletactivating factor (PAF) antagonist on the basis of computer modeling comparison studies with known PAF antagonis- ts. An efficient, four-step synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ab9a05cdf7f47b4d403c2a6f1a79da2
https://doi.org/10.1002/chin.199512163
https://doi.org/10.1002/chin.199512163
Autor:
Dirk Friederich, Norton P. Peet, Michael R. Angelastro, Roy J. Vaz, Robert J. Resvick, Joseph P. Burkhart, Cynthia A. Gates, Philip M. Weintraub, Philippe Bey
Publikováno v:
ChemInform. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf042586f64c0c1d0f2a0cab8c42c91a
https://doi.org/10.1002/chin.200220156
https://doi.org/10.1002/chin.200220156
Publikováno v:
The Journal of Organic Chemistry. 57:5150-5154
The syntheses of 2,19-(methyleneoxy)androst-4-ene-3,17-dione (4a), a potent, time-dependent inhibitor of human placental aromatase, and its thio (4b), amino (5), and methylene (14) analogs are described. The key step in the construction of 4a, 4b, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b9d0e2e52dcb19df3f549ad045c501a
https://doi.org/10.1021/jo00045a028
https://doi.org/10.1021/jo00045a028
Publikováno v:
Journal of Medicinal Chemistry. 35:3303-3306
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afcb90f48ec1dbf629ff828f282a5386
https://doi.org/10.1021/jm00095a030
https://doi.org/10.1021/jm00095a030
Publikováno v:
Tetrahedron Letters. 33:3265-3268
A concise method for the preparation of α-amino pentafluoroethyl ketone salts from amino acids is described. These intermediates are useful for the preparation of peptidyl pentafluoroethyl ketones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3645d42b5929840d4f37d07f283a3fa
https://doi.org/10.1016/s0040-4039(00)92063-x
https://doi.org/10.1016/s0040-4039(00)92063-x
Publikováno v:
Tetrahedron Letters. 31:1385-1388
A new method for the synthesis of peptidyl α-keto esters is described, which is particularly useful for the construction of proteinase inhibitors with a lysine side chain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f5bfffb1ad387aaab6c109f559cea2e
https://doi.org/10.1016/s0040-4039(00)88812-7
https://doi.org/10.1016/s0040-4039(00)88812-7