Výsledky vyhledávání - "Joseph P Y Kao"

Akademický článek

Ncm, a Photolabile Group for Preparation of Caged Molecules: Synthesis and Biological Application.

Autor: Sukumaran Muralidharan, Nathaniel D A Dirda, Elizabeth J Katz, Cha-Min Tang, Sharba Bandyopadhyay, Patrick O Kanold, Joseph P Y Kao

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0163937 (2016)

Ncm, 6-nitrocoumarin-7-ylmethyl, is a photolabile protective group useful for making "caged" molecules. Ncm marries the reliable photochemistry of 2-nitrobenzyl systems with the excellent stability and spectroscopic properties of the coumarin chromop

Externí odkaz: https://doaj.org/article/35d0f0ab7f1b4be19104b1e380715f68

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Akademický článek

Co-encapsulating the fusogenic peptide INF7 and molecular imaging probes in liposomes increases intracellular signal and probe retention.

Autor: Scott R Burks, Eric A Legenzov, Erik W Martin, Changqing Li, Wuyuan Lu, Joseph P Y Kao

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0120982 (2015)

Liposomes are promising vehicles to deliver diagnostic and therapeutic agents to cells in vivo. After uptake into cells by endocytosis, liposomes are degraded in the endolysosomal system. Consequently, the encapsulated cargo molecules frequently rema

Externí odkaz: https://doaj.org/article/85ac63e356d94e2ca4a791b2f915344c

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Akademický článek

Synthesis and Characterization of 8-O-Carboxymethylpyranine (CM-Pyranine) as a Bright, Violet-Emitting, Fluid-Phase Fluorescent Marker in Cell Biology.

Autor: Eric A Legenzov, Nathaniel D A Dirda, Brian M Hagen, Joseph P Y Kao

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0133518 (2015)

To avoid spectral interference with common fluorophores in multicolor fluorescence microscopy, a fluid-phase tracer with excitation and emission in the violet end of the visible spectrum is desirable. CM-pyranine is easily synthesized and purified. I

Externí odkaz: https://doaj.org/article/464b8e273d6b47ec8a94e6ce7d01e8da

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Akademický článek

Dendritic hold and read: a gated mechanism for short term information storage and retrieval.

Autor: Mariton D Santos, Michael H Mohammadi, Sunggu Yang, Conrad W Liang, Joseph P Y Kao, Bradley E Alger, Scott M Thompson, Cha-Min Tang

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37542 (2012)

Two contrasting theories have been proposed to explain the mechanistic basis of short term memory. One theory posits that short term memory is represented by persistent neural activity supported by reverberating feedback networks. An alternate, more

Externí odkaz: https://doaj.org/article/a950364a8180441fbbec45d5619980b9

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Akademický článek

Loss of Smyhc1 or Hsp90alpha1 function results in different effects on myofibril organization in skeletal muscles of zebrafish embryos.

Autor: Marta Codina, Junling Li, Joaquim Gutiérrez, Joseph P Y Kao, Shao Jun Du

Publikováno v: PLoS ONE, Vol 5, Iss 1, p e8416 (2010)

BACKGROUND: Myofibrillogenesis requires the correct folding and assembly of sarcomeric proteins into highly organized sarcomeres. Heat shock protein 90alpha1 (Hsp90alpha1) has been implicated as a myosin chaperone that plays a key role in myofibrillo

Externí odkaz: https://doaj.org/article/1008c93bed5646509adb9d0b25bd0127

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Akademický článek

Cortical inhibitory but not excitatory synaptic transmission and circuit refinement are altered after the deletion of NMDA receptors during early development

Autor: Rongkang Deng, Minzi Chang, Joseph P. Y. Kao, Patrick O. Kanold

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-22 (2023)

Abstract Neurons in the cerebral cortex form excitatory and inhibitory circuits with specific laminar locations. The mechanisms underlying the development of these spatially specific circuits is not fully understood. To test if postsynaptic N-methyl-

Externí odkaz: https://doaj.org/article/2d9db053e93743ad884c94712789a137

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Early retinal deprivation crossmodally alters nascent subplate circuits and activity in the auditory cortex during the precritical period

Autor: Didhiti Mukherjee, Binghan Xue, Chih-Ting Chen, Minzi Chang, Joseph P. Y. Kao, Patrick O. Kanold

Publikováno v: bioRxiv

Sensory perturbation in one modality results in adaptive reorganization of neural pathways within the spared modalities, a phenomenon known as “crossmodal plasticity”, which has been examined during or after the classic ‘critical period’. Bec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd51e6195c201ef07ee78e849b32fa81
https://europepmc.org/articles/PMC9980129/

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Impaired Hearing and Altered Subplate Circuits During the First and Second Postnatal Weeks of Otoferlin-Deficient Mice

Autor: Didhiti Mukherjee, Xiangying Meng, Patrick O. Kanold, Joseph P. Y. Kao

Publikováno v: Cereb Cortex

Sensory deprivation from the periphery impacts cortical development. Otoferlin deficiency leads to impaired cochlear synaptic transmission and is associated with progressive hearing loss in adults. However, it remains elusive how sensory deprivation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1789fe8889ee94c9eac5fd913128d26e
https://doi.org/10.1093/cercor/bhab383

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