Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Joseph P Mikusa"'
Autor:
Donna M. Gauvin, C.Z. Zhu, Rueter Le, Charles D. Mills, Lewis Lg, C.-H. Lee, Decker Mw, A.W. Bannon, C. Zhong, Hsieh Gc, Joshi Sk, Joseph P. Mikusa
Publikováno v:
European Journal of Pain. 16:816-826
Background Most animal models currently used to evaluate antinociceptive efficacy of analgesics rely on the assessment of evoked pain behaviours as primary endpoints. Mehtods Here, we have developed and characterized the carrageenaninduced locomotor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d22c202f77f0444c57d5bb915a60d8ce
https://doi.org/10.1002/j.1532-2149.2011.00099.x
https://doi.org/10.1002/j.1532-2149.2011.00099.x
Autor:
Rosemarie Roeloffs, Stephen Werness, Brian E. Marron, Chengmin Zhong, Brett Antonio, Ahmed H. Hakeem, Irene Drizin, Char-Chang Shieh, Mark L. Chapman, Joseph P. Mikusa, Marc J. C. Scanio, James B. Thomas, Shailen K. Joshi, Dong Liu, Mark A. Matulenko, Douglas S. Krafte, Robert N. Atkinson, Lei Shi, Kennan C. Marsh, Gricelda H. Simler, Matthew S Johnson, Michael J. Krambis, Kort Michael E, Michael F. Jarvis, Xu-Feng Zhang, Robert J. Gregg, Connie R. Faltynek, Matthew A. Secrest, Prisca Honore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6812-6815
A series of aryl-substituted nicotinamide derivatives with selective inhibitory activity against the Na(v)1.8 sodium channel is reported. Replacement of the furan nucleus and homologation of the anilide linker in subtype-selective blocker A-803467 (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0d6b9da5e44daf33aabb753a354c07
https://doi.org/10.1016/j.bmcl.2010.08.121
https://doi.org/10.1016/j.bmcl.2010.08.121
Autor:
Prisca Honore, Chang Z. Zhu, Joseph P. Mikusa, PR Hollingsworth, B B Yao, Michael J. Dart, Prasant Chandran, Y Fan, Madhavi Pai, Meyer, Anthony V. Daza, Michael W. Decker, Gin C. Hsieh
Publikováno v:
British Journal of Pharmacology. 157:645-655
Background and purpose: Activation of cannabinoid (CB) receptors decreases nociceptive transmission in inflammatory or neuropathic pain states. However, the effects of CB receptor agonists in post-operative pain remain to be investigated. Here, we ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15c8faeb58b8934eefb4d87235c8422a
https://doi.org/10.1111/j.1476-5381.2009.00184.x
https://doi.org/10.1111/j.1476-5381.2009.00184.x
Autor:
Jerome F. Daanen, Joseph P. Mikusa, Chih Hung Lee, Chengmin Zhong, Jason A. Segreti, Patrick W. Mantyh, Torben R. Neelands, Patricia N. Banfor, Michael F. Jarvis, Arthur Gomtsyan, Prasant Chandran, Molly A. Sevcik, Philip R. Kym, Donna M. Gauvin, Regina M. Reilly, Kennan C. Marsh, Michael E. Kort, Connie R. Faltynek, James P. Sullivan, Erol K. Bayburt, Carol S. Surowy, Joseph R. Ghilardi, Prisca Honore, Gricelda Hernandez, Ryan M. Fryer, Shailen K. Joshi
Publikováno v:
Pain. 142:27-35
Transient receptor potential vanilloid type 1 (TRPV1) is a ligand-gated ion channel that functions as an integrator of multiple pain stimuli including heat, acid, capsaicin and a variety of putative endogenous lipid ligands. TRPV1 antagonists have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26cec77f1eb7a5454a08a328e395101
https://doi.org/10.1016/j.pain.2008.11.004
https://doi.org/10.1016/j.pain.2008.11.004
Autor:
Matthew S Johnson, Dong Liu, Robert J. Gregg, Irene Drizin, Michael F. Gross, Gricelda Hernandez, Kennan C. Marsh, James B. Thomas, Mark L. Chapman, Chang Z. Zhu, Brian E. Marron, Connie R. Faltynek, Shailen K. Joshi, Prisca Honore, Stephen Werness, Michael E. Kort, Douglas S. Krafte, Robert N. Atkinson, Rosemarie Roeloffs, William A. Carroll, Marc J. C. Scanio, Xu-Feng Zhang, Donna M. Gauvin, Michael J. Krambis, Michael F. Jarvis, Char-Chang Shieh, Lei Shi, Joseph P. Mikusa
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:6379-6386
The synthesis and pharmacological characterization of a novel furan-based class of voltage-gated sodium channel blockers is reported. Compounds were evaluated for their ability to block the tetrodotoxin-resistant sodium channel Na(v)1.8 (PN3) as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdfd333e1e1c8103d37b0c3b7e0a15f
https://doi.org/10.1016/j.bmc.2008.05.003
https://doi.org/10.1016/j.bmc.2008.05.003
Autor:
William A Carroll, Chengmin Zhong, Stephen Werness, Jinrong Liu, Matthew S Johnson, Lei Shi, Michael F Jarvis, James B. Thomas, Xu-Feng Zhang, Mark L. Chapman, Michael F. Gross, Shailen Joshi, Michael E. Kort, Marc J. C. Scanio, Dong Liu, Robert J Gregg, Rosemarie Roeloffs, Prisca Honore, Gricelda Hernandez, Gregory J Pacofsky, Douglas S. Krafte, Robert N. Atkinson, Brian E. Marron, Irene I. Drizin, Kennan C Marsh, Joseph P Mikusa, Michael J. Krambis, Bernard P Murray, Char-Chang Shieh, Connie R. Faltynek
Publikováno v:
Journal of Medicinal Chemistry. 51:407-416
Nav1.8 (also known as PN3) is a tetrodotoxin-resistant (TTx-r) voltage-gated sodium channel (VGSC) that is highly expressed on small diameter sensory neurons and has been implicated in the pathophysiology of inflammatory and neuropathic pain. Recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4dee5ae6db88bda78289080d9f0fe12
https://doi.org/10.1021/jm070637u
https://doi.org/10.1021/jm070637u
Autor:
Steven W. Muchmore, Elizabeth A. Kowaluk, Kennan C. Marsh, Steve McGaraughty, Haixia Yu, Arthur Gomtsyan, Andrew O. Stewart, Shripad S. Bhagwat, Michael F. Jarvis, Karen M. Alexander, Kathy L. Kohlhaas, Clarissa L. Jakob, Chih-Hung Lee, Robin R. Frey, Mark A. Matulenko, Ernest S. Paight, Joseph P. Mikusa, Meiqun Jiang, Stanley Didomenico
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:1586-1605
A series of non-nucleoside adenosine kinase (AK) inhibitors is reported. These inhibitors originated from the modification of 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine (ABT-702). The identification of a linker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96eaee04592b0c71e6be749106b4cef1
https://doi.org/10.1016/j.bmc.2006.12.029
https://doi.org/10.1016/j.bmc.2006.12.029
Autor:
Prasant Chandran, Gricelda Hernandez, Michael W. Decker, Shailen K. Joshi, C.T. Wismer, Prisca Honore, C.Z. Zhu, Anita K. Salyers, C. Zhong, Joseph P. Mikusa
Publikováno v:
Neuroscience. 143:587-596
Intradermal capsaicin injection produces immediate spontaneous pain behaviors, and a secondary mechanical hypersensitivity (SMH) that is employed in the clinic as a model potentially predictive of human neuropathic pain. Presently, we have characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd3b2733659bd33554653ac6f00f13c
https://doi.org/10.1016/j.neuroscience.2006.08.005
https://doi.org/10.1016/j.neuroscience.2006.08.005
Autor:
C. Zhong, G Z Zheng, O El-Kouhen, Gerard B. Fox, R Chang, Prisca Honore, Mario Mezler, A O Stewart, Robert B. Moreland, Pramila Bhatia, S J Baker, T Kolasa, N M Rodell, Michael W. Decker, L N Miller, Jorge D. Brioni, E A Cronin, Katharine L. Chu, M E Uchic, M Patel, J. B. Pan, PR Hollingsworth, Steve McGaraughty, S G Lehto, Joseph P. Mikusa
Publikováno v:
British Journal of Pharmacology. 149:761-774
Background and purpose: To further assess the clinical potential of the blockade of metabotropic glutamate receptors (mGluR1) for the treatment of pain. Experimental approach: We characterized the effects of A-841720, a novel, potent and non-competit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f33eb66635c91316a322e2583e40a8cc
https://doi.org/10.1038/sj.bjp.0706877
https://doi.org/10.1038/sj.bjp.0706877
Autor:
Torben R. Neelands, C. Zhong, Erol K. Bayburt, B. Brown, Prisca Honore, Joseph P. Mikusa, W. Niforatos, Donna M. Gauvin, Gricelda Hernandez, H. McDonald, Michael W. Decker, Robert B. Moreland, Arthur Gomtsyan, Kennan C. Marsh, B. Bianchi, Prasant Chandran, Connie R. Faltynek, James P. Sullivan, C.-H. Lee, M. Cui
Publikováno v:
The Journal of Neuroscience. 26:9385-9393
Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. In addition to expression in primary affe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0d962b3ad79f4a5ab44823bdc3504b
https://doi.org/10.1523/jneurosci.1246-06.2006
https://doi.org/10.1523/jneurosci.1246-06.2006