Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Joseph P Califano"'
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32572 (2012)
Cancer cells exist in a mechanically and chemically heterogeneous microenvironment which undergoes dynamic changes throughout neoplastic progression. During metastasis, cells from a primary tumor acquire characteristics that enable them to escape fro
Externí odkaz:
https://doaj.org/article/13763e950c484b6f9a64cfab4a15f7be
Autor:
Robert Saddawi-Konefka, Aoife O’Farrell, Farhoud Faraji, Lauren Clubb, Michael M. Allevato, Shawn M. Jensen, Bryan S. Yung, Zhiyong Wang, Victoria H. Wu, Nana-Ama Anang, Riyam Al Msari, Shiruyeh Schokrpur, Ida Franiak Pietryga, Alfredo A. Molinolo, Jill P. Mesirov, Aaron B. Simon, Bernard A. Fox, Jack D. Bui, Andrew Sharabi, Ezra E. W. Cohen, Joseph A. Califano, J. Silvio Gutkind
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Response rates to immune checkpoint inhibitors (ICI) in patients with head and neck squamous cell carcinoma (HNSCC) remain low. Here the authors show that ablative treatment of tumor-draining regional lymphatics, a standard of care approach in patien
Externí odkaz:
https://doaj.org/article/45b1c1184762403b85513f3b2ecdf50e
Human papillomavirus E5 suppresses immunity via inhibition of the immunoproteasome and STING pathway
Autor:
Sayuri Miyauchi, Sangwoo S. Kim, Riley N. Jones, Lin Zhang, Kripa Guram, Sonia Sharma, Stephen P. Schoenberger, Ezra E.W. Cohen, Joseph A. Califano, Andrew B. Sharabi
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112508- (2023)
Summary: The role that human papillomavirus (HPV) oncogenes play in suppressing responses to immunotherapy in cancer deserves further investigation. In particular, the effects of HPV E5 remain poorly understood relative to E6 and E7. Here, we demonst
Externí odkaz:
https://doaj.org/article/0ab3a92f30554844b0725683d435e893
Autor:
Whitney Sumner, Sangwoo S. Kim, Lucas Vitzthum, Kevin Moore, Todd Atwood, James Murphy, Sayuri Miyauchi, Joseph A. Califano, Loren K. Mell, Arno J. Mundt, Andrew B. Sharabi
Publikováno v:
Radiation Oncology, Vol 16, Iss 1, Pp 1-9 (2021)
Abstract Background Image guidance in radiation oncology has resulted in significant improvements in the accuracy and precision of radiation therapy (RT). Recently, the resolution and quality of cone beam computed tomography (CBCT) for image guidance
Externí odkaz:
https://doaj.org/article/897156986eb2432faa50ee4b6328a3aa
Autor:
Zhiyong Wang, Yusuke Goto, Michael M. Allevato, Victoria H. Wu, Robert Saddawi-Konefka, Mara Gilardi, Diego Alvarado, Bryan S. Yung, Aoife O’Farrell, Alfredo A. Molinolo, Umamaheswar Duvvuri, Jennifer R. Grandis, Joseph A. Califano, Ezra E. W. Cohen, J. Silvio Gutkind
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
There is an unmet need to improve the response to immune checkpoint blockade in patients with head and neck squamous cell carcinoma (HNSCC). Here the authors show that aberrant HER3 activation sustains the proliferation of PIK3CA wild type HNSCC cell
Externí odkaz:
https://doaj.org/article/5c6d1bf166824a7299c38c08b6124d71
Autor:
Geoffri Ricci, Kevin Minsker, Austin Kapish, James Osborn, Sha Ha, Joseph Davide, Joseph P. Califano, Darrell Sehlin, Richard R. Rustandi, Lawrence W. Dick, Josef Vlasak, Timothy D. Culp, Andreas Baudy, Edward Bell, Malini Mukherjee
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Direct at line monitoring of live virus particles in commercial manufacturing of vaccines is challenging due to their small size. Detection of malformed or damaged virions with reduced potency is rate-limited by release potency assays with l
Externí odkaz:
https://doaj.org/article/6fd2905286724233b97e09383c9378da
Autor:
Mizuo Ando, Yuki Saito, Guorong Xu, Nam Q. Bui, Kate Medetgul-Ernar, Minya Pu, Kathleen Fisch, Shuling Ren, Akihiro Sakai, Takahito Fukusumi, Chao Liu, Sunny Haft, John Pang, Adam Mark, Daria A. Gaykalova, Theresa Guo, Alexander V. Favorov, Srinivasan Yegnasubramanian, Elana J. Fertig, Patrick Ha, Pablo Tamayo, Tatsuya Yamasoba, Trey Ideker, Karen Messer, Joseph A. Califano
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
In tumours aberrant epigenetic modifications can alter the transcriptional state. Here, the authors identify a common tumour-specific shift to transcriptional repression associated with DNA methylation and chromatin dysregulation at the transcription
Externí odkaz:
https://doaj.org/article/92171efeb0c747ec87436ef09a8ab860
Autor:
Daria A Gaykalova, Elizabeth Mambo, Ashish Choudhary, Jeffery Houghton, Kalyan Buddavarapu, Tiffany Sanford, Will Darden, Alex Adai, Andrew Hadd, Gary Latham, Ludmila V Danilova, Justin Bishop, Ryan J Li, William H Westra, Patrick Hennessey, Wayne M Koch, Michael F Ochs, Joseph A Califano, Wenyue Sun
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233409 (2020)
[This corrects the article DOI: 10.1371/journal.pone.0093102.].
Externí odkaz:
https://doaj.org/article/8c1619d622f047fbb4102119ccdb2917
Autor:
Akihiro Sakai, Mizuo Ando, Takahito Fukusumi, Shuling Ren, Chao Liu, Jesse Qualliotine, Sunny Haft, Sayed Sadat, Yuki Saito, Theresa W Guo, Guorong Xu, Roman Sasik, Kathleen M Fisch, J Silvio Gutkind, Elana J Fertig, Alfredo A Molinolo, Joseph A Califano
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233380 (2020)
Alternative mRNA splicing increases protein diversity, and alternative splicing events (ASEs) drive oncogenesis in multiple tumor types. However, the driving alterations that underlie the broad dysregulation of ASEs are incompletely defined. Using he
Externí odkaz:
https://doaj.org/article/f4066e559bd14055b02f0f7dceea5315
Autor:
Mohd Younis Bhat, Jayshree Advani, Pavithra Rajagopalan, Krishna Patel, Vishalakshi Nanjappa, Hitendra S. Solanki, Arun H. Patil, Firdous A. Bhat, Premendu P. Mathur, Bipin Nair, T. S. Keshava Prasad, Joseph A. Califano, David Sidransky, Harsha Gowda, Aditi Chatterjee
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Carcinogenic effect of tobacco in oral cancer is through chewing and/or smoking. Significant differences exist in development of oral cancer between tobacco users and non-users. However, molecular alterations induced by different forms of to
Externí odkaz:
https://doaj.org/article/c4c56ad91ce94c10877b609c90632134