Zobrazeno 1 - 10
of 456
pro vyhledávání: '"Joseph P, Ornato"'
Autor:
Jing Xu, Guanghui Zheng, Juntao Hu, Weiwei Ge, Jennifer L. Bradley, Joseph P. Ornato, Wanchun Tang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113847- (2022)
Post-resuscitation cerebral ischemia-reperfusion injury (IRI) is a vital contributor to poor neurological prognosis. Exploring novel therapeutics that attenuate cerebral IRI is of great significance. Inflammation plays a role in the development of ce
Externí odkaz:
https://doaj.org/article/17e1909e8165491db261c7204dbe7c59
Autor:
Changsheng Wang, Evelyne Bischof, Jing Xu, Qinyue Guo, Guanghui Zheng, Weiwei Ge, Juntao Hu, Elena Laura Georgescu Margarint, Jennifer L. Bradley, Mary Ann Peberdy, Joseph P. Ornato, Changqing Zhu, Wanchun Tang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundPrevious studies have demonstrated that inflammation and impaired microcirculation are key factors in post-resuscitation syndromes. Here, we investigated whether methylprednisolone (MP) could improve myocardial function and microcirculation
Externí odkaz:
https://doaj.org/article/532ebb3322cc43b093c284e56d114373
Autor:
Yan Xiao, Chenglei Su, Guozhen Zhang, Lian Liang, Tao Jin, Jennifer Bradley, Joseph P. Ornato, Wanchun Tang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 7 (2022)
Background Post‐resuscitation syndrome, involves a severe inflammatory response following successful cardiopulmonary resuscitation. The potential mechanism of Vitamin C (VitC) after cardiopulmonary resuscitation on myocardial and cerebral function,
Externí odkaz:
https://doaj.org/article/2e8184330bd84bebab1ebec126015b5d
Autor:
Guanghui Zheng, Jing Xu, Fenglian He, Juntao Hu, Weiwei Ge, Xianfei Ji, Changsheng Wang, Jennifer L. Bradley, Mary Ann Peberdy, Joseph P. Ornato, Stefano Toldo, Tong Wang, Wanchun Tang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 143, Iss , Pp 112093- (2021)
Cardiac arrest (CA) remains a major public health issue. Inflammatory responses with overproduction of interleukin-1β regulated by NLRP3 inflammasome activation play a crucial role in cerebral ischemia/reperfusion injury. We investigated the effects
Externí odkaz:
https://doaj.org/article/80c6f4fb5e3b4e75ba160f9f4c5ff4ad
Autor:
Lian Liang, Guozhen Zhang, Cheng Cheng, Hui Li, Tao Jin, Chenglei Su, Yan Xiao, Jennifer Bradley, Mary A. Peberdy, Joseph P. Ornato, Martin J. Mangino, Wanchun Tang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 142, Iss , Pp 111935- (2021)
The physiology and physiopathology process of mitochondrial function following cardiac arrest remains poorly understood. We aimed to assess mitochondrial respiratory function on the heart and brain homogenates from cardiac arrest rats. The expression
Externí odkaz:
https://doaj.org/article/9dab3724759f4e57be0c3829fb3e3159
Autor:
Xianfei Ji, Jennifer L. Bradley, Guanghui Zheng, Weiwei Ge, Jing Xu, Juntao Hu, Fenglian He, Rabiya Shabnam, Mary Ann Peberdy, Joseph P. Ornato, Qun Chen, Edward J. Lesnefsky, Wanchun Tang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 140, Iss , Pp 111743- (2021)
Brain mitochondria are more sensitive to global ischemia compared to heart mitochondria. Complex I in the electron transport chain (ETC) is sensitive to ischemic injury and is a major control point of the rate of ADP stimulated oxygen consumption. Th
Externí odkaz:
https://doaj.org/article/82cb046d56e94fe9a93c5f74b08e924a
Autor:
Qinyue Guo, Jin Yang, Zhangle Hu, Yan Xiao, Xiaobo Wu, Jennifer Bradley, Mary Ann Peberdy, Joseph P. Ornato, Martin J. Mangino, Wanchun Tang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 139, Iss , Pp 111646- (2021)
ABSTRACT: Out-of-hospital cardiac arrest (CA) is a leading cause of death in the United States. Severe post-resuscitation cerebral dysfunction is a primary cause of poor outcome. Therefore, we investigate the effects of polyethylene glycol-20k (PEG-2
Externí odkaz:
https://doaj.org/article/f0b78563e5e34a92b115829bbb01f671
Autor:
Lian Liang, Guozhen Zhang, Hui Li, Cheng Cheng, Tao Jin, Chenglei Su, Yan Xiao, Jennifer Bradley, Mary A. Peberdy, Joseph P. Ornato, Martin J. Mangino, Wanchun Tang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 9 (2021)
Background To investigate the therapeutic potential of combined therapy with polyethylene glycol‐20k (PEG‐20k) and MCC950 on post‐resuscitation myocardial function in a rat model of cardiac arrest. Methods and Results Thirty rats were randomize
Externí odkaz:
https://doaj.org/article/2aa36930f383496a82097d9a4ca8991b
Autor:
Cheng Cheng, Hui Li, Lian Liang, Tao Jin, Guozhen Zhang, Jennifer L. Bradley, Mary Ann Peberdy, Joseph P. Ornato, Dayanjan S. Wijesinghe, Wanchun Tang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 133, Iss , Pp 110970- (2021)
Accumulating evidence demonstrated that administration of ω-3 polyunsaturated fatty acid (ω-3 PUFA) or ascorbic acid (AA) following cardiac arrest (CA) improves survival. Therefore, we investigate the effects of ω-3 PUFA combined with AA on myocar
Externí odkaz:
https://doaj.org/article/d87e9c0e6deb420693d156e2a6fe35dd
Autor:
Weiwei Ge, Guanghui Zheng, Xianfei Ji, Fenglian He, Juntao Hu, Jennifer L. Bradley, Christine E. Moore, Mary A. Peberdy, Joseph P. Ornato, Martin J. Mangino, Wanchun Tang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 3 (2020)
Background Epinephrine increases the rate of return of spontaneous circulation. However, it increases severity of postresuscitation myocardial and cerebral dysfunction and reduces duration of survival. We investigated the effects of aortic infused po
Externí odkaz:
https://doaj.org/article/549e7a35892847ecbe737b7914cf3f1b