Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Joseph O. Polazzi"'
Autor:
Yatin R. Gokarn, Edward E. Remsen, Yiqing G. Feng, Joseph B. Monahan, Cindy Jarvis, Roger J. Schilling, Barbara K. Klein, William F. Hood, Joseph K. Welply, Jeng-Jong J. Shieh, John P. Mckearn, William D. Joy, Joseph O. Polazzi
Publikováno v:
Biochemistry. 40:13598-13606
Myelopoietins (MPOs) are a family of recombinant chimeric proteins that are both interleukin-3 (IL-3) receptor and granulocyte colony-stimulating factor (G-CSF) receptor agonists. In this study, MPO molecules containing one of three different IL-3 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c59248c16b6f7f16294d6429fcf0cec
https://doi.org/10.1021/bi010590t
https://doi.org/10.1021/bi010590t
Autor:
Violand Bernard N, Yiqing G. Feng, Kristin E Thomas, John C. Minnerly, Joseph O. Polazzi, Karl J. Mathis, David L. Zeng
Publikováno v:
Protein expression and purification. 26(2)
The progenipoietins (ProGPs) are a family of genetically engineered chimeric proteins that contain receptor agonist activity for both fetal liver tyrosine kinase-3 and the granulocyte colony-stimulating factor receptor. These unique proteins have pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15138bc402865fc01082b86a314f30db
https://pubmed.ncbi.nlm.nih.gov/12406682
https://pubmed.ncbi.nlm.nih.gov/12406682
Autor:
Joseph B. Monahan, Joseph K. Welply, Xiong Li, William F. Hood, Joseph O. Polazzi, Jeng-Jong J. Shieh
Publikováno v:
Experimental hematology. 29(4)
Leridistim is a member of a novel family of engineered chimeric cytokines, myelopoietins, that contain agonists of both interleukin-3 (IL-3) receptors (IL-3R) and granulocyte colony-stimulating factor (G-CSF) receptors (G-CSFR). To more clearly under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b70701581797a9b6ff2e4da8ed732a06
https://pubmed.ncbi.nlm.nih.gov/11301181
https://pubmed.ncbi.nlm.nih.gov/11301181
Autor:
Yiqing Feng, and Ann M. Donnelly, Joseph O. Polazzi, Edith S. Grabbe, Jeng-Jong Shieh, Barbara Kure Klein, Kumnan Paik, Linda L. Zurfluh, Mark P. Baganoff, John P. McKearn, Charles A. McWherter, William F. Hood, Ann L. Abegg
Publikováno v:
Biochemistry. 38(14)
Myelopoietins (MPOs) are a family of engineered dual interleukin-3 (IL-3) and granulocyte colony-stimulating factor (G-CSF) receptor agonists that are superior in comparison to the single agonists in their ability to promote the growth and maturation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922d5df240c06e04c290d67fa2c4ff50
https://pubmed.ncbi.nlm.nih.gov/10194378
https://pubmed.ncbi.nlm.nih.gov/10194378
Autor:
Kumnan Paik, Kris Sterbenz, Barrett R. Thiele, Sarah Ruth Braford-Goldberg, John P. McKearn, Barbara Kure Klein, S. Christopher Bauer, Alan Michael Easton, Peter O. Olins, Joseph O. Polazzi, Jon A. Klover, Maire Helena Caparon
Publikováno v:
The Journal of biological chemistry. 270(40)
A deletion variant of human interleukin-3, hIL-3(15-125), was produced in the periplasmic space of Escherichia coli and had full activity in an AML193.1.3 cell proliferation assay. Libraries of random single-amino acid substitutions were constructed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cad04817236bc23faf3e9c2e7c961cb
https://pubmed.ncbi.nlm.nih.gov/7559548
https://pubmed.ncbi.nlm.nih.gov/7559548
Autor:
Barbara Kure Klein, Catherine S. Devine, Joseph O. Polazzi, Shaukat H. Rangwala, Peter O. Olins
Publikováno v:
Protein engineering. 5(6)
Bovine somatotropin (bST) was secreted from Escherichia coli at moderate levels of 1-2 micrograms/ml/OD using expression vectors in which the bST gene was fused to the lamB secretion signal. To study the secretion properties of bST in E.coli further,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b42667bb181b61b155085c7a8b88b75
https://pubmed.ncbi.nlm.nih.gov/1438161
https://pubmed.ncbi.nlm.nih.gov/1438161
Publikováno v:
Journal of Medicinal Chemistry. 24:1445-1450
The preparation of a series of 7 alpha-alkylated dihydrocodeinones is described. N-(Cyclopropylmethyl) (P series) or N-(cyclobutylmethyl) (B series) 7 alpha-methyl (a series) or 7 alpha, 8 beta-dimethyl (b series) substituted dihydronorcodeinones (7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca3f78cdf2ea71d412ceb4af5a26aeb
https://doi.org/10.1021/jm00144a015
https://doi.org/10.1021/jm00144a015
Autor:
Joseph O. Polazzi, Michael P. Kotick
Publikováno v:
Journal of Heterocyclic Chemistry. 18:1029-1033
A series of 8β-substituted dihydrocodeinones, having hetero atoms in the side chain, were prepared. Michael addition of methanol or ethanol to 1 was accomplished under basic conditions, while the nitromethane adduct was prepared by a fluoride ion ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a63ec47bf470d99d13f5ea8ae8cd78ac
https://doi.org/10.1002/jhet.5570180535
https://doi.org/10.1002/jhet.5570180535
Publikováno v:
The Journal of Organic Chemistry. 45:4026-4028
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4c04d8583e9dc1d1e8a84b160ae7170
https://doi.org/10.1021/jo01308a016
https://doi.org/10.1021/jo01308a016
Publikováno v:
Journal of Medicinal Chemistry. 24:1516-1518
Series of N-(cyclopropylmethyl) (P series) or N-(cyclobutylmethyl) (B series) 3-methoxy (1) or 3-hydroxy (2) morphinan-6-ones with hydrogen (a), methyl (b), or ethyl (c) groups in the 8 beta position were converted to the 6-methylene compounds 3 or 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd47cbb54f0b1c05a54d7021f0c4b8ca
https://doi.org/10.1021/jm00144a029
https://doi.org/10.1021/jm00144a029