Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Joseph O'Flynn"'
1
Properdin binds independent of complement activation in an in vivo model of anti-glomerular basement membrane disease
Autor: Juha Kotimaa, Cordula M. Stover, Mohamed R. Daha, Angela Koudijs, Ngaisah Klar-Mohamad, Wilhelm J. Schwaeble, Ria Faber-Krol, Joseph O'Flynn, Cees van Kooten, Karin Koekkoek
Publikováno v: Kidney International, 94(6), 1141-1150
Properdin is the only known positive regulator of complement activation by stabilizing the alternative pathway convertase through C3 binding, thus prolonging its half-life. Recent in vitro studies suggest that properdin may act as a specific pattern
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f39e0978b0dfec6a8974535b2da1bb
http://hdl.handle.net/1887/96163
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2
Monomeric C-reactive protein inhibits renal cell-directed complement activation mediated by properdin
Autor: Zoltán Prohászka, Karen O. Dixon, Pieter van der Pol, Joseph O'Flynn, Cees van Kooten, Mohamed R. Daha
Publikováno v: American Journal of Physiology-Renal Physiology, 310(11), F1308-F1316
Previous studies have shown that complement activation on renal tubular cells is involved in the induction of interstitial fibrosis and cellular injury. Evidence suggests that the tubular cell damage is initiated by the alternative pathway (AP) of co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2598e13407a3e2f8641283fc307efa5c
https://hdl.handle.net/1887/113675
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3
Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses
Autor: Allison R. Bialas, Abhishek Das, Ronald Herbst, Joseph O'Flynn, Jordi Ochando, Gianluca Carlesso, Nanette Mittereder, Ian R. Rifkin, Balthasar A. Heesters, Michael C. Carroll
Publikováno v: Immunity
A hallmark of autoimmunity in murine models of lupus is the formation of germinal centers (GC) in lymphoid tissues where self-reactive B cells expand and differentiate. In the host response to foreign antigens, follicular dendritic cells (FDCs) are e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f58cbac2cf21c78215127dc218e481
https://pubmed.ncbi.nlm.nih.gov/28099860
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4
Nucleosomes and C1q bound to glomerular endothelial cells serve as targets for autoantibodies and determine complement activation
Autor: Mohamed R. Daha, Angelique L.W.M.M. Rops, Jo H. M. Berden, Joseph O'Flynn, Roelof Flierman, Simon C. Satchell, Cees van Kooten, Peter W. Mathieson, Johan van der Vlag, Pieter van der Pol
Publikováno v: Molecular Immunology, 49, 75-83
Molecular Immunology, 49(1-2), 75-83
Molecular Immunology, 49, 1-2, pp. 75-83
Contains fulltext : 96157.pdf (Publisher’s version ) (Closed access) Various studies indicate a role for both anti-nucleosome and anti-C1q autoantibodies in glomerulonephritis in patients with systemic lupus erythematosus. However, a causal relatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72769b72e273f1a96c5e7020d93111a
https://doi.org/10.1016/j.molimm.2011.07.020
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6
Functional assessment of mouse complement pathway activities. and quantification of C3b/C3c/iC3b in an experimental model of mouse renal ischaemia/reperfusion injury
Autor: Juha P. Kotimaa, Maaike B. van Werkhoven, Joseph O'Flynn, Ngaisah Klar-Mohamad, Jan van Groningen, Geurt Schilders, Helma Rutjes, Mohamed R. Daha, Marc A. Seelen, Cees van Kooten
Publikováno v: Journal of Immunological Methods, 419, 25-34. ELSEVIER SCIENCE BV
Journal of Immunological Methods, 419, 25-34
The complement system is an essential component of our innate immunity, both for the protection against infections and for proper handling of dying cells. However, the complement system can also contribute to tissue injury and inflammatory responses.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df7efd55037cb9056ba12c180df4856
https://hdl.handle.net/1887/101444
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7
FDCs regulate self-reactive memory B cells through CD21
Autor: Abhishek Das, Balthasar Heesters, Allison Bialas, Joseph O’Flynn, Michael C Carroll
Publikováno v: The Journal of Immunology. 198:54.7-54.7
B cells are the key mediators in many autoimmune diseases like systemic lupus erythematosus (SLE). Yet little is known about the cells and factors that are vital for maturation and sustenance of autoreactive B cells. One of the hallmarks of autoimmun
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e18f24e654479e4dc9ec824344db9f5
https://doi.org/10.4049/jimmunol.198.supp.54.7
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8
Differential complement activation pathways promote C3b deposition on native and acetylated LDL thereby inducing lipoprotein binding to the complement receptor 1
Autor: Pieter van der Pol, J. Wouter Jukema, Manuel Castro Cabezas, Cees van Kooten, Joseph O'Flynn, Tjin L. Njo, Ton J. Rabelink, Gert-Jan M. van de Geijn, Marijke A. de Vries, Peter de Man, Hans W. Janssen, Patrick C.N. Rensen, Selvetta van Santen, Robin van Bruggen, B. Klop, Yanan Wang
Publikováno v: Journal of Biological Chemistry, 289(51), 35421-35430
Journal of biological chemistry, 289(51), 35421-35430. American Society for Biochemistry and Molecular Biology Inc.
Lipoproteins can induce complement activation resulting in opsonization and binding of these complexes to complement receptors. We investigated the binding of opsonized native LDL and acetylated LDL (acLDL) to the complement receptor 1 (CR1). Binding
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc378305128d2b7875fa925cd7627be
https://pubmed.ncbi.nlm.nih.gov/25349208
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9
Phagocytosis of apoptotic or necrotic cells differentially regulates the transcriptional expression of IL-12 family members in dendritic cells
Autor: Sandra W. van der Kooij, Cees van Kooten, Karen O. Dixon, Joseph O'Flynn
Publikováno v: Journal of Leukocyte Biology, 96(2), 313-324
Uptake of apoptotic cells by DCs is considered to contribute to induction and maintenance of immunological tolerance. TolDCs are sought after as cellular therapy in transplantation and autoimmunity and can be generated in vitro using GCs. In this stu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a394428ee34ecfdcc78bc7409420b5f0
https://hdl.handle.net/1887/106800
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