Výsledky vyhledávání - "Joseph Nolfo"

High-Throughput Extractions: A New Paradigm for Workup Optimization in Pharmaceutical Process Development

Autor: Joseph Nolfo, Joshua A. Selekman, Michael Dummeldinger, Jacob M. Janey, Zhongmin Xu, Susanne Kiau, Kristy Tran

Publikováno v: Organic Process Research & Development. 20:1728-1737

In the pharmaceutical industry, high throughput (HT) technology is well developed and routinely utilized in chemical process development for reaction optimization and isolations via crystallization. However, fewer HT technologies have been employed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b7f4214996b3b8644eb71543da129bc
https://doi.org/10.1021/acs.oprd.6b00225

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Development of a Highly Automated Workflow for Investigating Polymorphism and Assessing Risk of Forming Undesired Crystal Forms within a Crystallization Design Space

Autor: Daniel G.M. Roberts, Qi Gao, Victor W. Rosso, Jun Qiu, Jacob M. Janey, Joshua A. Selekman, Joseph Nolfo

Publikováno v: Organic Process Research & Development. 20:70-75

A critical component of defining the feasible design space for an active pharmaceutical ingredient (API) crystallization is isolating the preferred polymorph or crystal form of the compound, which defines many of the compound’s performance-defining

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::439dbf02112a74e0d54938dd7de2e914
https://doi.org/10.1021/acs.oprd.5b00346

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GPCR Assay Automation for Leveraging Lead Optimization

Autor: Joseph Nolfo, Steve Kubala, Litao Zhang, Garrett Kolodin, Jing Chen, Mary Ellen Cvijic

Publikováno v: SLAS Technology. 17:266-274

The drug discovery process is dependent on the ability of screening efforts to identify and optimize lead compounds with therapeutic potential. Because G-protein-coupled receptors (GPCRs) account for the most "druggable" targets, the development of h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab241a5665b5cba65033ad54c2094e4
https://doi.org/10.1177/2211068212442502

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Development and Commercialization of the MiniBlock Synthesizer Family: A Historical Case Study

Autor: Harold N. Weller, Victor W. Rosso, Wenjeng Li, John William Allen, Walter Ruediger, Joseph Nolfo, Alexander Bertok, Ben Moshiri, A. Erik Rubin

Publikováno v: JALA: Journal of the Association for Laboratory Automation. 10:59-71

An internal development project at Bristol-Myers Squibb (BMS) led to invention of a family of organic chemistry synthesis blocks for both parallel synthesis in drug discovery and parallel reaction optimization in pharmaceutical development. The inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e6fe202666316ee749ef457b45d31ac
https://doi.org/10.1016/j.jala.2004.07.002

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