Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Joseph McGaunn"'
Autor:
Colin W. Garvie, Xiaoyun Wu, Malvina Papanastasiou, Sooncheol Lee, James Fuller, Gavin R. Schnitzler, Steven W. Horner, Andrew Baker, Terry Zhang, James P. Mullahoo, Lindsay Westlake, Stephanie H. Hoyt, Marcus Toetzl, Matthew J. Ranaghan, Luc de Waal, Joseph McGaunn, Bethany Kaplan, Federica Piccioni, Xiaoping Yang, Martin Lange, Adrian Tersteegen, Donald Raymond, Timothy A. Lewis, Steven A. Carr, Andrew D. Cherniack, Christopher T. Lemke, Matthew Meyerson, Heidi Greulich
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The small molecule DNMDP acts as a velcrin by inducing complex formation between phosphodiesterase PDE3A and SLFN12, which kills cancer cells that express sufficient levels of both proteins. Here, the authors present the cryo-EM structure of the DNMD
Externí odkaz:
https://doaj.org/article/8c9d393dbd6b4b13a8ba16d21da8b36d
Publikováno v:
Data in Brief, Vol 33, Iss , Pp 106398- (2020)
A dataset of chemical-gene interactions was created by extracting data from the Comparative Toxicogenomics Database (CTD) with the following filtering criteria: data was extracted only from experiments that used human, rat, or mouse cells/tissues and
Externí odkaz:
https://doaj.org/article/efced916bcea4611b231e63f77a08822
Autor:
Sooncheol Lee, Stephanie Hoyt, Xiaoyun Wu, Colin Garvie, Joseph McGaunn, Mrinal Shekhar, Marcus Tötzl, Matthew G. Rees, Andrew D. Cherniack, Matthew Meyerson, Heidi Greulich
Publikováno v:
Nature Chemical Biology. 19:301-310
Autor:
Saira Amir, Olatunbosun Arowolo, Ekaterina Mironova, Joseph McGaunn, Oladele Oluwayiose, Oleg Sergeyev, J. Richard Pilsner, Alexander Suvorov
Sperm epigenome undergoes age-dependent changes increasing risks of adverse conditions in offspring conceived by fathers of advanced age. The mechanism(s) linking paternal age with epigenetic changes in sperm remains unknown. The sperm epigenome is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::857fdc558a1258671c1c534cb854e1f6
https://doi.org/10.1101/2023.05.23.541978
https://doi.org/10.1101/2023.05.23.541978
Autor:
Stefan Gradl, Sooncheol Lee, Martin Lange, Xiaoyun Wu, Silvia Goldoni, Timothy Lewis, Charlotte Kopitz, Colin Garvie, Philip Lienau, Stephanie Hoyt, Henrik Seidel, Stephan Kaulfuss, Manuel Ellermann, Luc de Waal, Adrian Tersteegen, Sven Golfier, Detlev Suelzle, Christa Hegele-Hartung, James Carr, Frederick Brookfield, Michael Bruening, Melanie Berthold, Thibaud Jourdan, Monica Schenone, Galen Gao, Joseph McGaunn, Antje Wengner, Elisa Aquilanti, Franziska Siegel, Marine Garrido, Annette Walter, Isabelle Genvresse, Andrew Cherniack, Stuart Schreiber, Knut Eis, Ashley Eheim, Matthew Meyerson, Heidi Greulich
Publikováno v:
Cancer Research. 82:ND04-ND04
Velcrin compounds are a class of small molecules that induce complex formation between PDE3A and SLFN12, killing cancer cells that express elevated levels of these two proteins by a mechanism independent of PDE3A enzymatic inhibition. Instead, PDE3A
Autor:
Sooncheol Lee, Stephanie Hoyt, Xiaoyun Wu, Colin Garvie, Joseph McGaunn, Andrew D. Cherniack, Matthew Meyerson, Heidi Greulich
Publikováno v:
Cancer Research. 82:867-867
Velcrins are small molecules that induce apoptosis of cancer cells expressing high levels of phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12) by inducing PDE3A-SLFN12 complex formation. Recently, we found that SLFN12 is an RNase an
Autor:
Stephanie Hoyt, Sooncheol Lee, Joseph McGaunn, Andrew Cherniack, Matthew Meyerson, Heidi Greulich
Publikováno v:
Cancer Research. 82:879-879
Velcrin compounds kill cancer cells expressing high levels of PDE3A and SLFN12 by inducing complex formation between these two proteins, but the mechanism of cancer cell killing by the PDE3A-SLFN12 complex is not fully understood. We previously deter
Autor:
Adrian Tersteegen, Stephanie H. Hoyt, Steven A. Carr, Donald Raymond, Christopher T. Lemke, Federica Piccioni, James Mullahoo, Martin Lange, Xiaoping Yang, Bethany Kaplan, Colin W. Garvie, Andrew Baker, Marcus Toetzl, Heidi Greulich, Malvina Papanastasiou, Steven Horner, Luc de Waal, Timothy A. Lewis, James R. Fuller, Sooncheol Lee, Lindsay Westlake, Andrew D. Cherniack, Joseph McGaunn, Terry Zhang, Gavin R. Schnitzler, Matthew Meyerson, Matthew J. Ranaghan, Xiaoyun Wu
Publikováno v:
'Nature Communications ', vol: 12, pages: 4375-1-4375-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
DNMDP and related compounds, or velcrins, induce complex formation between the phosphodiesterase PDE3A and the SLFN12 protein, leading to a cytotoxic response in cancer cells that express elevated levels of both proteins. The mechanisms by which velc
Autor:
Colin W. Garvie, Martin Lange, Stephanie H. Hoyt, James Mullahoo, Matthew Meyerson, Andrew D. Cherniack, Terry Zhang, Joseph McGaunn, Xiaoyun Wu, Steven A. Carr, Heidi Greulich, Xiaoping Yang, Gavin R. Schnitzler, Andrew Baker, Bethany Kaplan, Sooncheol Lee, Federica Piccioni, Malvina Papanastasiou
Publikováno v:
Cancer Research. 81:1219-1219
PDE3A-SLFN12 complex formation is induced by a class of compounds, now called “velcrins”, exemplified by the small molecule, DNMDP. Cancer cells that express elevated levels of PDE3A and SLFN12 are sensitive to a velcrin-mediated cytotoxic respon
Autor:
Luc de Waal, Matthew Meyerson, Bethany Kaplan, Colin W. Garvie, Martin Lange, Timothy A. Lewis, Sooncheol Lee, Heidi Greulich, Andrew Baker, Steven Horner, Chris Lemke, Xiaoyun Wu, Joseph McGaunn, Marcus Toetzl
Publikováno v:
Cancer Research. 81:54-54
We have identified a novel mechanism of selective cancer cell-killing, whereby small molecules such as DNMDP induce complex formation between phosphodiesterase 3A (PDE3A) and a poorly characterized protein, SLFN12, that leads to downstream cell death