Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Joseph McClanaghan"'
Autor:
Nishanth Ulhas Nair, Patricia Greninger, Xiaohu Zhang, Adam A. Friedman, Arnaud Amzallag, Eliane Cortez, Avinash Das Sahu, Joo Sang Lee, Anahita Dastur, Regina K. Egan, Ellen Murchie, Michele Ceribelli, Giovanna S. Crowther, Erin Beck, Joseph McClanaghan, Carleen Klump-Thomas, Jessica L. Boisvert, Leah J. Damon, Kelli M. Wilson, Jeffrey Ho, Angela Tam, Crystal McKnight, Sam Michael, Zina Itkin, Mathew J. Garnett, Jeffrey A. Engelman, Daniel A. Haber, Craig J. Thomas, Eytan Ruppin, Cyril H. Benes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Combination of anti-cancer drugs is broadly seen as way to overcome the often-limited efficacy of single agents. The design and testing of combinations are however very challenging. Here we present a uniquely large dataset screening over 500
Externí odkaz:
https://doaj.org/article/74d18fafe3754d38962c3b1365fa27b3
Autor:
Jinyang Cai, Sheeba Jacob, Richard Kurupi, Krista M. Dalton, Colin Coon, Patricia Greninger, Regina K. Egan, Giovanna T. Stein, Ellen Murchie, Joseph McClanaghan, Yuta Adachi, Kentaro Hirade, Mikhail Dozmorov, John Glod, Sosipatros A. Boikos, Hiromichi Ebi, Huaixiang Hao, Giordano Caponigro, Cyril H. Benes, Anthony C. Faber
Publikováno v:
Cell Reports, Vol 40, Iss 4, Pp 111095- (2022)
Summary: Reoccurring/high-risk neuroblastoma (NB) tumors have the enrichment of non-RAS/RAF mutations along the mitogen-activated protein kinase (MAPK) signaling pathway, suggesting that activation of MEK/ERK is critical for their survival. However,
Externí odkaz:
https://doaj.org/article/3169f73446bb4502b9e30b3d5f9b0105
Autor:
Byunghee Yoo, Patricia Greninger, Giovanna T Stein, Regina K Egan, Joseph McClanaghan, Anna Moore, Cyril H Benes, Zdravka Medarova
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0201046 (2018)
Since microRNAs (miRNAs, miRs) have been implicated in oncogenesis, many of them have been identified as therapeutic targets. Previously we have demonstrated that miRNA-10b acts as a master regulator of the viability of metastatic tumor cells and rep
Externí odkaz:
https://doaj.org/article/7d4e07a6112548db9914389c72aecba7
Autor:
Lei Shi, William Shen, Mindy I. Davis, Ke Kong, Phuong Vu, Supriya K. Saha, Ramzi Adil, Johannes Kreuzer, Regina Egan, Tobie D. Lee, Patricia Greninger, Jonathan H. Shrimp, Wei Zhao, Ting-Yu Wei, Mi Zhou, Jason Eccleston, Jonathan Sussman, Ujjawal Manocha, Vajira Weerasekara, Hiroshi Kondo, Vindhya Vijay, Meng-Ju Wu, Sara E. Kearney, Jeffrey Ho, Joseph McClanaghan, Ellen Murchie, Giovanna S. Crowther, Samarjit Patnaik, Matthew B. Boxer, Min Shen, David T. Ting, William Y. Kim, Ben Z. Stanger, Vikram Deshpande, Cristina R. Ferrone, Cyril H. Benes, Wilhelm Haas, Matthew D. Hall, Nabeel Bardeesy
Publikováno v:
Nature Cancer. 4:365-381
Autor:
Cyril H. Benes, Anthony C. Faber, Michelle Kelliher, Jeffrey A. Engelman, Kathryn Rizzo, Steven Grant, Jorge Almenara, Mathew J. Garnett, Ultan McDermott, Jessica Boisvert, Neha U. Patel, Justine Roderick, Max Greenberg, Joseph McClanaghan, August Williams, Xunqin Yin, Carlotta Costa, AHyun Choi, Anahita Dastur
Materials & Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b14822c5acd6fb07c51fdf79be930e6
https://doi.org/10.1158/1078-0432.22473366.v1
https://doi.org/10.1158/1078-0432.22473366.v1
Autor:
Cyril H. Benes, Aaron N. Hata, Yi Liu, Lian-Sheng Li, Matthew R. Janes, Patrick P. Zarrinkar, Ellen Murchie, Giovanna T. Stein, Joseph McClanaghan, Regina K. Egan, Patricia Greninger, Varuna Nangia, Max Greenberg, Maria Gomez-Caraballo, Dana Lee, David T. Myers, Daria Timonina, Samantha Bilton, Chendi Li, Eliane Cortez, Jackson P. Fatherree, Sandra Misale
Supplementary Figure 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c6002e1de0b9fa72e7c7ac907e910c7
https://doi.org/10.1158/1078-0432.22475831.v1
https://doi.org/10.1158/1078-0432.22475831.v1
Autor:
Cyril H. Benes, Aaron N. Hata, Yi Liu, Lian-Sheng Li, Matthew R. Janes, Patrick P. Zarrinkar, Ellen Murchie, Giovanna T. Stein, Joseph McClanaghan, Regina K. Egan, Patricia Greninger, Varuna Nangia, Max Greenberg, Maria Gomez-Caraballo, Dana Lee, David T. Myers, Daria Timonina, Samantha Bilton, Chendi Li, Eliane Cortez, Jackson P. Fatherree, Sandra Misale
Purpose:KRAS-mutant lung cancers have been recalcitrant to treatments including those targeting the MAPK pathway. Covalent inhibitors of KRAS p.G12C allele allow for direct and specific inhibition of mutant KRAS in cancer cells. However, as for other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8066f1e76350109a82cce15e9ec86925
https://doi.org/10.1158/1078-0432.c.6529181
https://doi.org/10.1158/1078-0432.c.6529181
Autor:
Cyril H. Benes, Anthony C. Faber, Michelle Kelliher, Jeffrey A. Engelman, Kathryn Rizzo, Steven Grant, Jorge Almenara, Mathew J. Garnett, Ultan McDermott, Jessica Boisvert, Neha U. Patel, Justine Roderick, Max Greenberg, Joseph McClanaghan, August Williams, Xunqin Yin, Carlotta Costa, AHyun Choi, Anahita Dastur
Purpose:Effective targeted therapies are lacking for refractory and relapsed T-cell acute lymphoblastic leukemia (T-ALL). Suppression of the NOTCH pathway using gamma-secretase inhibitors (GSI) is toxic and clinically not effective. The goal of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15477f6b40651ca7df1e85c44af1b8a4
https://doi.org/10.1158/1078-0432.c.6528492
https://doi.org/10.1158/1078-0432.c.6528492
Autor:
Cyril H. Benes, Aaron N. Hata, Yi Liu, Lian-Sheng Li, Matthew R. Janes, Patrick P. Zarrinkar, Ellen Murchie, Giovanna T. Stein, Joseph McClanaghan, Regina K. Egan, Patricia Greninger, Varuna Nangia, Max Greenberg, Maria Gomez-Caraballo, Dana Lee, David T. Myers, Daria Timonina, Samantha Bilton, Chendi Li, Eliane Cortez, Jackson P. Fatherree, Sandra Misale
Supplementary Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5a896d86ec7e50b167343ffefbbee1
https://doi.org/10.1158/1078-0432.22475804
https://doi.org/10.1158/1078-0432.22475804
Autor:
Cyril H. Benes, Aaron N. Hata, Yi Liu, Lian-Sheng Li, Matthew R. Janes, Patrick P. Zarrinkar, Ellen Murchie, Giovanna T. Stein, Joseph McClanaghan, Regina K. Egan, Patricia Greninger, Varuna Nangia, Max Greenberg, Maria Gomez-Caraballo, Dana Lee, David T. Myers, Daria Timonina, Samantha Bilton, Chendi Li, Eliane Cortez, Jackson P. Fatherree, Sandra Misale
Supplementary Data 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf000d7760f0e4664c37f7049ea2bd89
https://doi.org/10.1158/1078-0432.22475834
https://doi.org/10.1158/1078-0432.22475834