Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Joseph M. Vitolo"'
Extended Transgene Expression From a Nonintegrating Adenoviral Vector Containing Retroviral Elements
Autor:
Weitian Zhang, John A. Chiorini, Bruce J. Baum, Changyu Zheng, Fumi Mineshiba, Joseph M. Vitolo
Publikováno v:
Molecular Therapy. 16:1089-1097
We studied the effects of specific retroviral elements in a first-generation serotype 5 adenoviral (Ad5) vector, AdLTR(2)EF1alpha-hEPO. This vector contains 858 base pair (bp) [251-bp envelope sequence plus 607-bp long-terminal repeat (LTR)] from Mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65db5bd6806fc68e9b32d6524c81c969
https://doi.org/10.1038/mt.2008.56
https://doi.org/10.1038/mt.2008.56
Kinetics of Tempol for Prevention of Xerostomia Following Head and Neck Irradiation in a Mouse Model
Autor:
Anastasia L. Sowers, Albert Kingman, Bruce J. Baum, James B. Mitchell, Ana P. Cotrim, Angelo Russo, Beatrijs M. Lodde, Joseph M. Vitolo
Publikováno v:
Clinical Cancer Research. 11:7564-7568
Purpose: Radiotherapy is commonly used to treat the majority of patients with head and neck cancers. Salivary glands in the radiation field are dramatically affected by this procedure. The purpose of this study was to examine pharmacokinetic characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e85b69471c3f561f0de5dab4a0c31f7
https://doi.org/10.1158/1078-0432.ccr-05-0958
https://doi.org/10.1158/1078-0432.ccr-05-0958
Autor:
Stanley R. Pillemer, Anastasia L. Sowers, James B. Mitchell, Ana P. Cotrim, Angelo Russo, Joseph M. Vitolo, Bruce J. Baum, Robert B. Wellner
Publikováno v:
Clinical Cancer Research. 10:1807-1812
Purpose: Radiotherapy is commonly used to treat a majority of patients with head and neck cancers. The long-term radiation-induced reduction of saliva output significantly contributes to the posttreatment morbidity experienced by these patients. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e022e423b20b6c2964e01798e6fd385
https://doi.org/10.1158/1078-0432.ccr-03-0194
https://doi.org/10.1158/1078-0432.ccr-03-0194
Publikováno v:
Molecular and Cellular Biology. 24:697-707
Assembly of a DNA fragment containing a Xenopus borealis somatic-type 5S RNA gene into a nucleosome greatly restricts binding of the 5S gene-specific transcription factor IIIA (TFIIIA) to the 5S internal promoter. However, TFIIIA binds with high affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc95fe0effb8b37960277444d90b9f6
https://doi.org/10.1128/mcb.24.2.697-707.2004
https://doi.org/10.1128/mcb.24.2.697-707.2004
Publikováno v:
Proceedings of the National Academy of Sciences. 98:6599-6604
Within chromatin, the core histone tail domains play critical roles in regulating the structure and accessibility of nucleosomal DNA within the chromatin fiber. Thus, many nuclear processes are facilitated by concomitant posttranslational modificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0870b31de51a047c305f4bde51147280
https://doi.org/10.1073/pnas.121171498
https://doi.org/10.1073/pnas.121171498
Publikováno v:
Biochemistry. 39:3835-3841
Modulation of nucleosome stability in chromatin plays an important role in eukaryotic gene expression. The core histone N-terminal tail domains are believed to modulate the stability of wrapping nucleosomal DNA and the stability of the chromatin fila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47fbad0c001040e4d2312c367418329
https://doi.org/10.1021/bi991957l
https://doi.org/10.1021/bi991957l
Publikováno v:
Molecular and Cellular Biology. 20:2167-2175
Reconstitution of a DNA fragment containing a Xenopus borealis somatic type 5S rRNA gene into a nucleosome greatly restricts the binding of transcription factor IIIA (TFIIIA) to its cognate DNA sequence within the internal promoter of the gene. Remov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298db50176df0709dd9338f26c92af9d
https://doi.org/10.1128/mcb.20.6.2167-2175.2000
https://doi.org/10.1128/mcb.20.6.2167-2175.2000
Publikováno v:
The EMBO journal. 19(20)
The access to DNA within nucleosomes is greatly restricted for most enzymes and trans-acting factors that bind DNA. We report here that human DNA ligase I, which carries out the final step of Okazaki fragment processing and of many DNA repair pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d45c972bb5e9c82a4803b32fbe1d407
https://pubmed.ncbi.nlm.nih.gov/11032816
https://pubmed.ncbi.nlm.nih.gov/11032816
Publikováno v:
Current Protocols in Molecular Biology
The native chromatin complex within most eukaryotic nuclei is very difficult to study by biochemical means, so researchers have developed methods for studying smaller portions of the complex. This unit details the use of DNase I and hydroxyl radicals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539456bb2aa88af8a820c3d7097089ba
https://doi.org/10.1002/0471142727.mb2104s48
https://doi.org/10.1002/0471142727.mb2104s48
Publikováno v:
Molecular Therapy. 11:S339-S340
Previously, we reported the construction of a prototype hybrid adenoretroviral vector, AdLTR-luc, which included Moloney murine leukemia virus (MoMLV) elements flanking (|[sim]| 2.7 kb 5|[prime]|; |[sim]| 1 kb 3|[prime]|) transgene cassette (Zheng et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77679278cae27543440e51c7f069f5ab
https://doi.org/10.1016/j.ymthe.2005.07.420
https://doi.org/10.1016/j.ymthe.2005.07.420