Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Joseph M. Schrader"'
Autor:
Joseph M. Schrader, Feng Xu, Kevin J. Agostinucci, Nicholas A. DaSilva, William E. Van Nostrand
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Cerebral amyloid angiopathy (CAA) is a prevalent vascular dementia and common comorbidity of Alzheimer’s disease (AD). While it is known that vascular fibrillar amyloid β (Aβ) deposits leads to vascular deterioration and can drive parenc
Externí odkaz:
https://doaj.org/article/16717bd1d98b4e0f84140aa0750b19aa
Autor:
Marc Vervuurt, Joseph M. Schrader, Anna M. de Kort, Iris Kersten, Hans J. C. T. Wessels, Catharina J. M. Klijn, Floris H. B. M. Schreuder, H. Bea Kuiperij, Jolein Gloerich, William E. Van Nostrand, Marcel M. Verbeek
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-15 (2024)
Abstract Cerebral amyloid angiopathy (CAA) is a form of small vessel disease characterised by the progressive deposition of amyloid β protein in the cerebral vasculature, inducing symptoms including cognitive impairment and cerebral haemorrhages. Du
Externí odkaz:
https://doaj.org/article/ae6635b300cb4d1ebf5188677a8dfa6a
Autor:
Aleksandra Stanisavljevic, Joseph M. Schrader, Xiaoyue Zhu, Jennifer M. Mattar, Ashley Hanks, Feng Xu, Mark Majchrzak, John K. Robinson, William E. Van Nostrand
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Cerebral amyloid angiopathy (CAA), a common comorbidity of Alzheimer’s disease (AD), is a cerebral small vessel disease (CSVD) characterized by deposition of fibrillar amyloid β (Aβ) in blood vessels of the brain and promotes neuroinflammation an
Externí odkaz:
https://doaj.org/article/3d685743950d4ba79f5863eedd544880
Autor:
Xiaoyue Zhu, Joseph M. Schrader, Brandon A. Irizarry, Steven O. Smith, William E. Van Nostrand
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2982 (2022)
Fibrillar amyloid β-protein (Aβ) deposits in the brain, which are primarily composed of Aβ40 or Aβ42 peptides, are key pathological features of Alzheimer’s disease (AD) and related disorders. Although the underlying mechanisms are still not cle
Externí odkaz:
https://doaj.org/article/f9e72154e7304181be9bc76737c5cf89
Autor:
Joseph M. Schrader, Feng Xu, Hedok Lee, Benjamin Barlock, Helene Benveniste, William E. Van Nostrand
Publikováno v:
Am J Pathol
Cerebral amyloid angiopathy (CAA), characterized by cerebral vascular amyloid accumulation, neuroinflammation, microbleeds, and white matter (WM) degeneration, is a common comorbidity in Alzheimer disease and a prominent contributor to vascular cogni
Publikováno v:
J Neurochem
Cerebral amyloid angiopathy (CAA), a prevalent cerebral small vessel disease in the elderly and a common comorbidity of Alzheimer's disease, is characterized by cerebral vascular amyloid accumulation, cerebral infarction, microbleeds, and intracerebr
Publikováno v:
J Neuropathol Exp Neurol
Cerebral small vessel diseases (CSVDs) are prominent contributors to vascular cognitive impairment and dementia and can arise from a range of etiologies. Cerebral amyloid angiopathy (CAA) and hypertension (HTN), both prevalent in the elderly populati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a769c97375cca86d228157abf458026d
https://europepmc.org/articles/PMC9803909/
https://europepmc.org/articles/PMC9803909/
Autor:
Judianne Davis, Helene Benveniste, Xiaoyue Zhu, Douglas L. Rothman, Hedok Lee, Aleksandra Stanisavljevic, Xiaodan Liu, Joseph M. Schrader, David Yanez, Feng Xu, William E. Van Nostrand, Sunil Koundal, Joanna M. Wardlaw
Publikováno v:
Lee, H, Xu, F, Liu, X, Koundal, S, Zhu, X, Davis, J, Yanez, D, Schrader, J, Stanisavljevic, A, Rothman, D L, Wardlaw, J, Van Nostrand, W E & Benveniste, H 2020, ' Diffuse white matter loss in a transgenic rat model of cerebral amyloid angiopathy ', Journal of Cerebral Blood Flow and Metabolism, pp. 0271678X2094422 . https://doi.org/10.1177/0271678X20944226
J Cereb Blood Flow Metab
J Cereb Blood Flow Metab
Diffuse white matter (WM) disease is highly prevalent in elderly with cerebral small vessel disease (cSVD). In humans, cSVD such as cerebral amyloid angiopathy (CAA) often coexists with Alzheimer’s disease imposing a significant impediment for char
Autor:
William E. Van Nostrand, Annemieke Peters van Ton, Wilson F. Abdo, Anna M. de Kort, Catharina J.M. Klijn, Gisela M. Terwindt, Xiaoyue Zhu, Joseph M. Schrader, Marcel M. Verbeek, Iris Kersten, Marc Vervuurt, Floris H.B.M. Schreuder, Tainá M. Marques, Steven M. Greenberg, Marieke J.H. Wermer, Ingeborg Rasing, Bea Kuiperij
Publikováno v:
Neuropathology and Applied Neurobiology, 48, 5
Neuropathology and Applied Neurobiology, 48(5). WILEY
Neuropathology and Applied Neurobiology, 48
Neuropathology and Applied Neurobiology, 48(5). WILEY
Neuropathology and Applied Neurobiology, 48
Objective: To study the association of urokinase plasminogen activator (uPA) with development and progression of cerebral amyloid angiopathy (CAA) in a rat model for CAA type-I (rTg-DI) and in patients with sporadic (sCAA) and Dutch-type hereditary C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8691bc38a743ae4f20c6eb0bd23bf1
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/282539
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/282539
Autor:
Craig M. Irving, Joseph Conti, Joseph M. Schrader, Joseph A. Christian, Timothy J. Aballo, J. Christopher Octeau, Dean J. Kareemo, Abraham Kovoor, Jonathan A. Javitch, Jodi L. Camberg, J. Robert Lane
Most clinically available antipsychotic drugs (APDs) bind dopamine D2 receptors (D2R) at therapeutic concentrations, and it is thought that they suppress psychotic symptoms by serving as competitive antagonists of dopamine at D2R. Here, we present da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671c676caedded477c208693fc2d86bf
https://europepmc.org/articles/PMC6462534/
https://europepmc.org/articles/PMC6462534/