Pregabalin as adjunctive therapy in adult and pediatric patients with generalized tonic‐clonic seizures: A randomized, placebo‐controlled trial

Autor: Joseph Driscoll, Mary Almas, Gabriela Gregorian, Alla Kyrychenko, Iryna Makedonska, Jing Liu, Jeffrey Patrick, Joseph M. Scavone, Jeremias Antinew, the 1105 Study Group

Publikováno v: Epilepsia Open, Vol 6, Iss 2, Pp 381-393 (2021)

Abstract Objective Generalized tonic‐clonic (GTC) seizures are the most common type of generalized seizure and more common in children than adults. This phase 3 study evaluated the efficacy and safety of pregabalin for GTC seizures in adults and ch

Externí odkaz: https://doaj.org/article/be20ba2c7a844cdca420a3e3e6ea6f2a

Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations

Autor: Joachim Scholz, Roger B. Fillingim, David Yarnitsky, Tina Tockarshewsky, Shannon M. Smith, Dennis C. Turk, Shay Bujanover, Daniel B. Carr, Nadine Attal, Joanna M. Brell, Jeffrey Tobias, Nathaniel P. Katz, Penney Cowan, Joseph M. Scavone, Mila Etropolski, Martin S. Angst, Linda Porter, Jennifer S. Gewandter, Simon Haroutounian, Warren Wen, Robert H. Dworkin, Raymond A. Dionne, Mark Versavel, John D. Markman, Ajay D. Wasan, Christine Veasley, Lee S. Simon, Andrew S.C. Rice, Per Hansson, Robert R. Edwards, Ernest A. Kopecky, Lars Arendt-Nielsen, Amy S. Chappell, R. Baron, Bob A. Rappaport, George G. Nomikos, Laurie B. Burke, Roy Freeman

Publikováno v: PAIN Reports, Vol 6, Iss 1, p e899 (2021)
Edwards, R R, Dworkin, R H, Turk, D C, Angst, M S, Dionne, R, Freeman, R, Hansson, P, Haroutounian, S, Arendt-Nielsen, L, Attal, N, Baron, R, Brell, J, Bujanover, S, Burke, L B, Carr, D, Chappell, A S, Cowan, P, Etropolski, M, Fillingim, R B, Gewandter, J S, Katz, N P, Kopecky, E A, Markman, J D, Nomikos, G, Porter, L, Rappaport, B A, Rice, A S C, Scavone, J M, Scholz, J, Simon, L S, Smith, S M, Tobias, J, Tockarshewsky, T, Veasley, C, Versavel, M, Wasan, A D, Wen, W & Yarnitsky, D 2016, ' Patient phenotyping in clinical trials of chronic pain treatments : IMMPACT recommendations ', Pain, vol. 157, no. 9, pp. 1851-1871 . https://doi.org/10.1097/j.pain.0000000000000602
Edwards, R R, Dworkin, R H, Turk, D C, Angst, M S, Dionne, R, Freeman, R, Hansson, P, Haroutounian, S, Arendt-Nielsen, L, Attal, N, Baron, R, Brell, J, Bujanover, S, Burke, L B, Carr, D, Chappell, A S, Cowan, P, Etropolski, M, Fillingim, R B, Gewandter, J S, Katz, N P, Kopecky, E A, Markman, J D, Nomikos, G, Porter, L, Rappaport, B A, Rice, A S C, Scavone, J M, Scholz, J, Simon, L S, Smith, S M, Tobias, J, Tockarshewsky, T, Veasley, C, Versavel, M, Wasan, A D, Wen, W & Yarnitsky, D 2021, ' Patient phenotyping in clinical trials of chronic pain treatments : IMMPACT recommendations ', Pain Reports, vol. 6, no. 1, e896 . https://doi.org/10.1097/pr9.0000000000000896

There is tremendous interpatient variability in the response to analgesic therapy (even for efficacious treatments), which can be the source of great frustration in clinical practice. This has led to calls for “precision medicine” or personalized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd9ba5c6f5ac347f31b08f2ced337c8
http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000000896

Effect of Baseline Characteristics on the Pain Response to Pregabalin in Fibromyalgia Patients with Comorbid Depression

Autor: Stuart L. Silverman, Miroslav Backonja, Richard Vissing, Pritha Bhadra Brown, Lynne Pauer, Andrew Clair, Jaren W. Landen, Joseph M. Scavone

Publikováno v: Pain Medicine. 19:419-428

Objective To evaluate the effect of baseline characteristics on the treatment response to pregabalin in fibromyalgia (FM) patients with depression. Design Post hoc analysis from a randomized, double-blind, placebo-controlled, two-way crossover study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef125aa708ce3c7781c42ad8f80e371c
https://doi.org/10.1093/pm/pnx091

Pregabalin in Patients With Painful Diabetic Peripheral Neuropathy Using an NSAID for Other Pain Conditions

Autor: Joseph M. Scavone, Cynthia Huffman, Bruce Parsons, Philip Raskin, Ruoyong Yang, Lorraine Yurkewicz, Lynne Pauer

Publikováno v: The Clinical Journal of Pain. 32:203-210

To evaluate pregabalin's efficacy and safety versus placebo to reduce pain in patients with diabetic peripheral neuropathy (DPN) using a concomitant nonsteroidal anti-inflammatory drug.In a randomized, double-masked, 14-week, 2-period, crossover stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf32345f8dc4ea82a0b791f28dc29cf
https://doi.org/10.1097/ajp.0000000000000254

Pregabalin Controlled-Release Pharmacokinetics in Healthy Volunteers: Analysis of Four Multiple-Dose Randomized Clinical Pharmacology Studies

Autor: Verne Pitman, Christine Alvey, Joseph M. Scavone, Tanja Alebic-Kolbah, Howard N. Bockbrader, Marci L. Chew, Anna Plotka

Publikováno v: Clinical Drug Investigation. 34:627-637

Pregabalin (Lyrica®) is approved as an immediate-release (IR) formulation for administration twice (BID) or three times (TID) a day depending on indication. Once daily (QD) dosing may be appropriate for ease of clinical use and patient convenience.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae2361dfacbe45d54d30f5b3e3836def
https://doi.org/10.1007/s40261-014-0221-2