Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Joseph M. Santin"'
Autor:
Lara Amaral-Silva, Joseph M. Santin
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Neural circuit function is highly sensitive to energetic limitations. Much like mammals, brain activity in American bullfrogs quickly fails in hypoxia. However, after emergence from overwintering, circuits transform to function fo
Externí odkaz:
https://doaj.org/article/ef59f7876a8148c4b5d37b381db6dd24
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Neural networks tune synaptic and cellular properties to produce stable activity. One form of homeostatic regulation involves scaling the strength of synapses up or down in a global and multiplicative manner to oppose activity disturbances.
Externí odkaz:
https://doaj.org/article/83cfa136549d4bcc98c75f1456d3f6bb
Autor:
Michael Gray, Joseph M. Santin
Publikováno v:
Journal of Neurophysiology. 129:1177-1190
Voltage errors occur in whole cell voltage clamp. We make, to our knowledge, the first direct measurements of these errors and find that voltage errors are far smaller than standard calculations would predict. Since voltage errors were often minimal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1c7e63d65e865a74a683b7203ce8b84
https://doi.org/10.1152/jn.00476.2022
https://doi.org/10.1152/jn.00476.2022
Publikováno v:
bioRxiv
Brain energy stress leads to neuronal hyperexcitability followed by a rapid loss of function and cell death. In contrast, the frog brain switches into a state of extreme metabolic resilience that allows them to maintain motor function during hypoxia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcfeeee5fe18c2179cd3b2e7f464b2ed
https://europepmc.org/articles/PMC9882286/
https://europepmc.org/articles/PMC9882286/
Autor:
Min Hu, Joseph M. Santin
Publikováno v:
Proceedings of the Royal Society B: Biological Sciences. 289
Neural activity is costly and requires continuous ATP from aerobic metabolism. Brainstem motor function of American bullfrogs normally collapses after minutes of ischaemia, but following hibernation, it becomes ischaemia-tolerant, generating output f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781f67d2bed25631d2e097e99bdaed49
https://doi.org/10.1098/rspb.2022.1131
https://doi.org/10.1098/rspb.2022.1131
Autor:
Lara Amaral-Silva, Joseph M. Santin
Publikováno v:
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. :111453
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19add3a315bcfc9508897ef7092e6068
https://doi.org/10.1016/j.cbpa.2023.111453
https://doi.org/10.1016/j.cbpa.2023.111453
Publikováno v:
Scientific reports. 12(1)
Neural networks tune synaptic and cellular properties to produce stable activity. One form of homeostatic regulation involves scaling the strength of synapses up or down in a global and multiplicative manner to oppose activity disturbances. In Americ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bc522a0be2357e814b1c09ca007c9692
https://pubmed.ncbi.nlm.nih.gov/35803955
https://pubmed.ncbi.nlm.nih.gov/35803955
Publikováno v:
PLOS Biology. 21:e3001971
Neurons tightly regulate firing rate and a failure to do so leads to multiple neurological disorders. Therefore, a fundamental question in neuroscience is how neurons produce reliable activity patterns for decades to generate behavior. Neurons have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85843ee5ed8536ee6ef7f79444849c8d
https://doi.org/10.1371/journal.pbio.3001971
https://doi.org/10.1371/journal.pbio.3001971
Molecular profiling of single neurons of known identity in two ganglia from the crab Cancer borealis
Autor:
David J. Schulz, Eve Marder, Adam J. Northcutt, Joseph M. Santin, Adriane G Otopalik, Robert M Harris, Benjamin M. Goetz, Daniel R Kick, Hans A. Hofmann
Publikováno v:
Proceedings of the National Academy of Sciences. 116:26980-26990
Understanding circuit organization depends on identification of cell types. Recent advances in transcriptional profiling methods have enabled classification of cell types by their gene expression. While exceptionally powerful and high throughput, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::822dfa65d1b69a4367ece059d5f53afe
https://doi.org/10.1073/pnas.1911413116
https://doi.org/10.1073/pnas.1911413116
Publikováno v:
J Physiol
Lactate ion sensing has emerged as a process that regulates ventilation during metabolic challenges. Most work has focused on peripheral sensing of lactate for the control of breathing. However, lactate also rises in the central nervous system (CNS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b412c3378619c0884a803fff43035a
https://europepmc.org/articles/PMC8696744/
https://europepmc.org/articles/PMC8696744/