Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Joseph M. Penninger"'
Autor:
Marko Poglitsch, Manfred Schuster, Hans Loibner, M. Bruggisser, Marc Salzberg, Joseph M. Penninger, Manuel Haschke, Stephan Krähenbühl
Publikováno v:
Clinical Pharmacokinetics. 52:783-792
Angiotensin-converting enzyme 2 (ACE2) converts angiotensin II (Ang1-8) to angiotensin 1-7 (Ang1-7), a functional antagonist of Ang1-8, with vasodilatory, antiproliferative, antiangiogenic, and anti-inflammatory properties. In conditions with an unba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79281a7c4805f93bf9e487327deb4f2
https://doi.org/10.1007/s40262-013-0072-7
https://doi.org/10.1007/s40262-013-0072-7
Autor:
Valentina Mosienko, Robson A.S. Santos, Daisy Motta-Santos, Marko Poglitsch, Natalia Alenina, Michael Bader, Fatimunnisa Qadri, Marilene L. Oliveira, Maria José Campagnole-Santos, Joseph M. Penninger, Lenice Kappes Becker
Publikováno v:
Hypertension research : official journal of the Japanese Society of Hypertension. 39(7)
The renin-angiotensin system (RAS) is related to physiological adaptations induced by exercise. Angiotensin-converting enzyme (ACE) 2 is a major regulator of the RAS in tissues, as it metabolizes angiotensin (Ang) II to Ang-(1-7). The aim of this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d185fdf0cb86c8334f12d453fce388
https://pubmed.ncbi.nlm.nih.gov/27053009
https://pubmed.ncbi.nlm.nih.gov/27053009
Autor:
Edith Charlier, Patrizia Agostinis, Alain Chariot, Laurence Deneubourg, Stuart M. Haslam, Souad Rahmouni, Christophe Erneux, Anne Dell, Geoffrey Gloire, Joseph M. Penninger, P-C Pang, Cecilia B Conde, Jacques Piette, E Di Valentin, Junyu Zhang
Publikováno v:
Leukemia. 24(4)
SHIP-1 (SH2 (Src homology 2)-containing inositol 5'-phosphatase-1) functions as a negative regulator of immune responses by hydrolyzing phosphatidylinositol-3,4,5-triphosphate generated by phosphoinositide-3 (PI 3)-kinase activity. As a result, SHIP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4667af33303e56a24a72353700ad2e
https://pubmed.ncbi.nlm.nih.gov/20147977
https://pubmed.ncbi.nlm.nih.gov/20147977
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 22(6)
Within the past decade, the critical roles of T cells and T cell-mediated immunity in inflammation-induced osteoclastogenesis and subsequent bone loss have been extensively studied, thereby establishing the new paradigm of osteoimmunology. Therefore,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d85170f08572466b900d0a6014c57d6
https://pubmed.ncbi.nlm.nih.gov/17352656
https://pubmed.ncbi.nlm.nih.gov/17352656
Autor:
Bhagirath Singh, Yen-Tung A. Teng, Annette M. Marleau, Deeqa Mahamed, Mawadda Alnaeeli, Xiaoxia Zhang, Joseph M. Penninger
Publikováno v:
Diabetes. 54(5)
Diabetic patients experience a higher risk for severe periodontitis; however, the underlying mechanism remains unclear. We investigated the contribution of antibacterial T-cell–mediated immunity to enhanced alveolar bone loss during periodontal inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3dc451daa3c276ead509c4c322da4f
https://pubmed.ncbi.nlm.nih.gov/15855336
https://pubmed.ncbi.nlm.nih.gov/15855336
Autor:
Klaus Okkenhaug, Jason G. Cyster, Bart Vanhaesebroeck, Karin Reif, Joseph M. Penninger, Takehiko Sasaki
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 173(4)
Despite the established role for PI3Ks in cell migration, the PI3Ks involved in lymphocyte chemotaxis are poorly defined. In this study, we report that p110γ-deficient T cells, but not B cells, show reduced chemotactic responses to the lymphoid chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8312911e755e8853c3593d82ae5935
https://pubmed.ncbi.nlm.nih.gov/15294934
https://pubmed.ncbi.nlm.nih.gov/15294934
Autor:
Christophe Erneux, Sylvie Giuriato, Xavier Pesesse, Evelyne Marion, Cécile Viala, Bernard Payrastre, Stéphane Bodin, Stéphane Schurmans, Takehiko Sasaki, Joseph M. Penninger
Publikováno v:
The Biochemical journal. 376(Pt 1)
Src homology domain 2-containing inositol 5-phosphatases 1 and 2 (SHIP1 and SHIP2) are capable of dephosphorylating the second messenger PtdIns(3,4,5)P3 (phosphatidylinositol 3,4,5-trisphosphate) and interacting with several signalling proteins. SHIP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54c6961ff7a7ff701f1bd0fe8991c2d
https://pubmed.ncbi.nlm.nih.gov/12885297
https://pubmed.ncbi.nlm.nih.gov/12885297
Autor:
Jacques Emile Dumont, Xavier Pesesse, Willy Malaisse, Joseph M. Penninger, Stéphane Schurmans, Louis Hue, Y. Le Marchand-Brustel, Takehiko Sasaki, Ulrike Krause, Jens Behrends, Jean-François Tanti, Serge Clément, F. Desmedt, Margaret Doherty, Christophe Erneux
Publikováno v:
Nature. 431:878-878
Nature 409, 92–96 (2001). In this Letter, we investigated the production and the phenotypic characterization of a SHIP2 (SH2 domain containing inositol phosphate 5-phosphatase type 2, or Inppl1) knockout mice. Total or partial loss of SHIP2 enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5b7ea1894b05291732d99bc885dcf23
https://doi.org/10.1038/nature03003
https://doi.org/10.1038/nature03003