Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Joseph M. Pastore"'
Autor:
Timothy D. Henry, Saihari Sadanandan, Mehdi H. Shishehbor, Vikram S. Kashyap, Joseph M. Pastore, Leslie W. Miller, Parag D Patel, Tarek A Hammad, Matthew C. Bunte, John H. Rundback, Michael L. Fitzgerald
Publikováno v:
Journal of Endovascular Therapy. 27:669-675
Purpose: To present the 6-month results of the Stromal Cell–Derived Factor-1 Plasmid Treatment for Patients with Peripheral Artery Disease (STOP-PAD) trial. The trial was an attempt to alter the course of chronic limb-threatening ischemia (CLTI) wi
Autor:
Mehdi H. Shishehbor, Timothy D. Henry, Vikram S. Kashyap, Tarek A. Hammad, Matthew C. Bunte, Parag D Patel, Michael L. Fitzgerald, John H. Rundback, Joseph M. Pastore, Leslie Miller, Saihari Sadanandan
Publikováno v:
Vascular Medicine. 24:200-207
The efficacy of biologic therapies in critical limb ischemia (CLI) remains elusive, in part, due to limitations in trial design and patient selection. Using a novel design, we examined the impact of complementing revascularization therapy with intram
Autor:
Leslie W. Miller, Russell David Anderson, Saif Anwaruddin, Farrell O. Mendelsohn, Jay H. Traverse, Amit N. Patel, Kevin H. Silver, Rahul Aras, Mary Jane Farr, Gregory A. Ewald, Scott J. Fisher, Joseph M. Pastore, Alexander T. AuWerter, Eugene S. Chung, Francis Plat, Marc S. Penn, Julia Shin
Publikováno v:
European Heart Journal. 36:2228-2238
Background Stromal cell-derived factor-1 (SDF-1) promotes tissue repair through mechanisms of cell survival, endogenous stem cell recruitment, and vasculogenesis. Stromal Cell-Derived Factor-1 Plasmid Treatment for Patients with Heart Failure (STOP-H
Autor:
Ruth Clemens, Rahul Aras, Maryjane Farr, Gary L. Schaer, Warren Sherman, Joseph M. Pastore, Douglas W. Losordo, Marc S. Penn, Farrell O. Mendelsohn, Didier Rouy
Publikováno v:
Circulation Research. 112:816-825
Rationale: Preclinical studies indicate that adult stem cells induce tissue repair by activating endogenous stem cells through the stromal cell-derived factor-1:chemokine receptor type 4 axis. JVS-100 is a DNA plasmid encoding human stromal cell-deri
Publikováno v:
Heart Rhythm. 3:711-719
Background Spatially discordant cellular alternans form a substrate for development of unidirectional block and ventricular fibrillation. However, the mechanisms responsible for discordant alternans remain poorly understood. Previous work suggests el
Autor:
Michael L. Fitzgerald, Farrell O. Mendelsohn, Marc S. Penn, Melina R. Kibbe, Joseph R McShannic, Rahul Aras, Rajiv Parakh, Joseph M. Pastore, Jason Q Alexander, Ajay Yadav
Publikováno v:
Circulation. 130
Background: Stromal cell-derived factor-1 (SDF-1) promotes tissue repair by increasing cell survival, endogenous stem cell recruitment and vasculogenesis. Preclinical studies demonstrated that non-viral DNA plasmid encoding human SDF-1 (pSDF-1) is sa
Autor:
Vojtech Melenovsky, Joseph M. Pastore, Andrew P. Kramer, Ronald D. Berger, Ilan Hay, Barry A. Borlaug, Barry J. Fetics, David A. Kass
Publikováno v:
European Heart Journal. 26:705-711
Aims Atrial fibrillation (AFib) with a rapid ventricular response may adversely impact cardiac performance, especially in patients with heart failure. However, it remains uncertain whether rhythm irregularity per se has unfavourable effects apart fro
Autor:
Susanna Cahn, Joseph M. Pastore
Publikováno v:
Teaching Business Ethics. 7:329-340
All agree that moral issues are difficult issues mired in philosophical, political, social, and spiritual values. It's no wonder that the process of calculating moral positions has been likened to ``eating broth with a fork.'' While insuring moral be
Autor:
David S. Rosenbaum, Joseph M. Pastore
Publikováno v:
Circulation Research. 87:1157-1163
Abstract —Previously, using an animal model of T-wave alternans in structurally normal myocardium, we demonstrated that repolarization can alternate with opposite phase between neighboring myocytes (ie, discordant alternans), causing spatial disper
Publikováno v:
Circulation. 99:1385-1394
Background —Although T-wave alternans has been closely associated with vulnerability to ventricular arrhythmias, the cellular processes underlying T-wave alternans and their role, if any, in the mechanism of reentry remain unclear. Methods and Resu