Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Joseph M. Parker"'
Autor:
Charles Nakar, Heather McDaniel, Joseph M. Parker, Karen Thibaudeau, Neelam Thukral, Amy D. Shapiro
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
Plasminogen deficiency type 1 (PLGD-1, hypoplasminogenemia) is an ultra-rare, lifelong disease associated with development of fibrinous lesions in multiple organ systems. Depending on lesion location, clinical manifestations of PLGD-1 can result in a
Externí odkaz:
https://doaj.org/article/34a8a62f1f7c4028be26d8ed79ae06e3
A Phase 2 Randomized Controlled Study of Tralokinumab in Subjects with Idiopathic Pulmonary Fibrosis
Autor:
Joseph M. Parker, Kevin R. Flaherty, Jon P. Fiening, Dewei She, Stephanie L. Roseti, Chris Kell, Ethan Grant, Tarik Haddad, Ian Glaspole, Lisa Lancaster
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 197:94-103
IL-13 is a potential therapeutic target for idiopathic pulmonary fibrosis (IPF); preclinical data suggest a role in tissue fibrosis, and expression is increased in subjects with rapidly progressing disease.Investigate efficacy and safety of tralokinu
Publikováno v:
Blood. 136:5-6
Congenital plasminogen deficiency (C-PLGD) is a rare autosomal recessive multisystem disorder of the fibrinolytic system that is often underdiagnosed. It is caused by mutations in the PLG gene and is characterized by extravascular fibrinous deposits
Autor:
John E. Moran, Gary R. Albert, Lyne Gagnon, Nasreen Khalil, Martin Kolb, Frank Cesari, Joseph M. Parker, Christopher J. Ryerson, Renata Sawtell, Paul Hernandez, Aline Hagerimana, Pierre Laurin, Eric Turcotte, Shane Shapera, Hélène Manganas, André M. Cantin
Publikováno v:
The European Respiratory Journal
PBI-4050 is a novel orally active small-molecule compound with demonstrated anti-fibrotic activity in several models of fibrosis, including lung fibrosis. We present results from our first clinical study of PBI-4050 in patients with idiopathic pulmon
Autor:
Amy D. Shapiro, Heather McDaniel, Charles Nakar, Joseph M. Parker, Diane Trybul, Neelam Thukral
Publikováno v:
Blood. 136:2-2
C-PLGD is a rare autosomal recessive multisystem disorder of the fibrinolytic system. Mutations in the PLG gene result in extravascular fibrinous deposits, termed ligneous for their woody appearance, that accumulate on mucous membranes such as the co
Autor:
Gary R. Albert, Joseph M. Parker, John E. Moran, Brandon M. Hardesty, Pierre Laurin, Neelam Thukral, Per Morten Sandset, Charles Nakar, Karen Thibaudeau, Amy D. Shapiro
Publikováno v:
Blood. 131(12)
Congenital plasminogen deficiency is caused by mutations in PLG, the gene coding for production of the zymogen plasminogen, and is an ultrarare disorder associated with abnormal accumulation or growth of fibrin-rich pseudomembranous lesions on mucous
Autor:
Hassan A. Ahmad, G. Wendell Richmond, Stacy Plum, John Moran, James N. Moy, Joseph M. Parker, Diane Trybul
Publikováno v:
Journal of Allergy and Clinical Immunology. 143:AB114
Autor:
Morten Olsen, Xiao Xu, Martin Berg Johansen, Sigrun A. Johannesdottir, Timothy L. Lash, Joseph M. Parker, Nestor A. Molfino, Christian Fynbo Christiansen, Jon P. Fryzek
Publikováno v:
Johannesdottir, S A, Christiansen, C F, Johansen, M B, Olsen, M, Xu, X, Parker, J M, Molfino, N A, Lash, T L & Fryzek, J P 2013, ' Hospitalization with acute exacerbation of chronic obstructive pulmonary disease and associated health resource utilization : a population-based Danish cohort study ', Journal of Medical Economics, vol. 16, no. 7, pp. 897-906 . https://doi.org/10.3111/13696998.2013.800525
Health resource utilization (HRU) and outcomes associated with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) are not well described. Therefore, a population-based cohort study was conducted to characterize patients hospitalized
Autor:
Kevin R. Flaherty, Ethan Grant, Ian Glaspole, StephanieL. Roseti, Joseph M. Parker, Chris Kell, Lisa Lancaster, Jon P. Fiening, Dewei She
Publikováno v:
QJM: An International Journal of Medicine.
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
Frontiers in Pharmacology
Frontiers in Pharmacology
Fibrosis, the definition for which being the formation of fibrous tissue in an organ or a specific region of the body, can often be a life threatening pathology or condition. Whilst fibrosis is often readily discernable by simple histology, the causa