Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Joseph M. Paggi"'
Autor:
Alexander S. Powers, Helen H. Yu, Patricia Suriana, Rohan V. Koodli, Tianyu Lu, Joseph M. Paggi, Ron O. Dror
Publikováno v:
ACS Central Science, Vol 9, Iss 12, Pp 2257-2267 (2023)
Externí odkaz:
https://doaj.org/article/0287fec22131434e8136f0325cd1b189
Autor:
Amal El Daibani, Joseph M. Paggi, Kuglae Kim, Yianni D. Laloudakis, Petr Popov, Sarah M. Bernhard, Brian E. Krumm, Reid H. J. Olsen, Jeffrey Diberto, F. Ivy Carroll, Vsevolod Katritch, Bernhard Wünsch, Ron O. Dror, Tao Che
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Biased signaling in κ-opiod receptors (KOR) offer an attractive strategy for pain management. Here the authors identify determinants of KOR signaling bias using structural methods in combination with molecular dynamics simulations.
Externí odkaz:
https://doaj.org/article/937c35a4ce1e4c9d8b16be30f0910f0c
Autor:
Eric M Jones, Nathan B Lubock, AJ Venkatakrishnan, Jeffrey Wang, Alex M Tseng, Joseph M Paggi, Naomi R Latorraca, Daniel Cancilla, Megan Satyadi, Jessica E Davis, M Madan Babu, Ron O Dror, Sriram Kosuri
Publikováno v:
eLife, Vol 9 (2020)
The >800 human G protein–coupled receptors (GPCRs) are responsible for transducing diverse chemical stimuli to alter cell state- and are the largest class of drug targets. Their myriad structural conformations and various modes of signaling make it
Externí odkaz:
https://doaj.org/article/eef860197db949eb8e173ad8316b333e
Autor:
Qianhui Qu, Weijiao Huang, Deniz Aydin, Joseph M. Paggi, Alpay B. Seven, Haoqing Wang, Soumen Chakraborty, Tao Che, Jeffrey F. DiBerto, Michael J. Robertson, Asuka Inoue, Carl-Mikael Suomivuori, Bryan L. Roth, Susruta Majumdar, Ron O. Dror, Brian K. Kobilka, Georgios Skiniotis
Publikováno v:
Nature Chemical Biology. 19:423-430
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7359c5cc984e9bb96ea9d0131a946064
https://doi.org/10.1038/s41589-022-01208-y
https://doi.org/10.1038/s41589-022-01208-y
Autor:
Joseph M. Paggi, Deniz Aydin, Yianni D. Laloudakis, Carl-Mikael Suomivuori, Tao Che, Ron O. Dror
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b7c035050a8c1e35d3f01958deec175
https://doi.org/10.1124/jpet.122.274970
https://doi.org/10.1124/jpet.122.274970
Publikováno v:
PLoS Genetics, Vol 14, Iss 8, p e1007588 (2018)
Recursive splicing, a process by which a single intron is removed from pre-mRNA transcripts in multiple distinct segments, has been observed in a small subset of Drosophila melanogaster introns. However, detection of recursive splicing requires obser
Externí odkaz:
https://doaj.org/article/d0908a0b30c34360be862b7909c81a92
Autor:
Seiya Tajima, Yoon Seok Kim, Masahiro Fukuda, Eamon F.X. Byrne, Peter Y. Wang, Joseph M. Paggi, Koichiro E. Kishi, Charu Ramakrishnan, Syunki Takaramoto, Takashi Nagata, Masae Konno, Masahiro Sugiura, Kota Katayama, Toshiki E. Matsui, Keitaro Yamashita, Hisako Ikeda, Masatoshi Inoue, Hideki Kandori, Ron O. Dror, Keiichi Inoue, Karl Deisseroth, Hideaki E. Kato
SUMMARYThe KCR channelrhodopsins are recently-discovered light-gated ion channels with high K+selectivity, a property that has attracted broad attention among biologists– due to intense interest in creating novel inhibitory tools for optogenetics l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::838220718371e1a51e9fa3438f3392bc
https://doi.org/10.1101/2022.10.30.514430
https://doi.org/10.1101/2022.10.30.514430
Autor:
Qianhui Qu, Weijiao Huang, Deniz Aydin, Joseph M. Paggi, Alpay B. Seven, Haoqing Wang, Soumen Chakraborty, Tao Che, Jeffrey F. DiBerto, Michael J. Robertson, Asuka Inoue, Bryan L. Roth, Susruta Majumdar, Ron O. Dror, Brian K. Kobilka, Georgios Skiniotis
Drugs targeting the G protein-coupled μ-opioid receptor (μOR) are the most effective analgesics available but are also associated with fatal respiratory depression. While some partial opioid agonists appear to be safer than full agonists, the signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cdc0373d23a6ff0c82de20926714cec
https://doi.org/10.1101/2021.12.07.471645
https://doi.org/10.1101/2021.12.07.471645
Autor:
Qianhui, Qu, Weijiao, Huang, Deniz, Aydin, Joseph M, Paggi, Alpay B, Seven, Haoqing, Wang, Soumen, Chakraborty, Tao, Che, Jeffrey F, DiBerto, Michael J, Robertson, Asuka, Inoue, Carl-Mikael, Suomivuori, Bryan L, Roth, Susruta, Majumdar, Ron O, Dror, Brian K, Kobilka, Georgios, Skiniotis
Publikováno v:
Nature chemical biology.
Drugs targeting the μ-opioid receptor (μOR) are the most effective analgesics available but are also associated with fatal respiratory depression through a pathway that remains unclear. Here we investigated the mechanistic basis of action of lofent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::583d5eafb087c976d4c9320dbeb60416
https://pubmed.ncbi.nlm.nih.gov/36411392
https://pubmed.ncbi.nlm.nih.gov/36411392
Autor:
Tsukasa Kusakizako, Mikihiro Shibata, Masahiro Fukuda, Tomoko Uemura, Koichiro E. Kishi, Joseph M. Paggi, Keitaro Yamashita, Hideaki E. Kato, Keiichi Inoue, Ron O. Dror, Tyler Benster, Takashi Nagata, So Iwata, Peter Y. Wang, Masae Konno, Toshiki E. Matsui, Charu Ramakrishnan, Kehong Liu, Masatoshi Inoue, Karl Deisseroth, Norimichi Nomura, Elina Thadhani, Yoon Seok Kim, Eamon F. X. Byrne, Osamu Nureki
SummaryChRmine1, a recently-discovered bacteriorhodopsin-like cation-conducting channelrhodopsin1, 2, exhibits puzzling properties (unusually-large photocurrents, exceptional red-shift in action spectrum, and extreme light-sensitivity) that have open
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c69d3b2fd614f297e2fb15ea3d4dfaf
https://doi.org/10.1101/2021.08.15.456392
https://doi.org/10.1101/2021.08.15.456392