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pro vyhledávání: '"Joseph M. Notarfrancesco"'
Autor:
John W. Stoddart, John C. Ruggiero, Kevin S. Gilroy, Joseph M. Notarfrancesco, Joseph J. Butera, Sachin P. Patil, Jonathan D. Griffin, Michael F. Pacitti, Shawn Tran
Publikováno v:
Journal of Computer-Aided Molecular Design. 29:155-163
The inhibition of tumor suppressor p53 protein due to its direct interaction with oncogenic murine double minute 2 (MDM2) protein, plays a central role in almost 50 % of all human tumor cells. Therefore, pharmacological inhibition of the p53-binding