Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Joseph M. Maturo"'
Publikováno v:
Endocrinology. 133(2)
Hyperinsulinism, insulin resistance, and decreased number of insulin receptors are characteristic of obesity in both humans and experimental animals. To assess the role of insulin in developing obesity, diazoxide (DZ), an inhibitor of glucose-stimula
Publikováno v:
Journal of Cellular Biochemistry. 28:143-157
The receptor for both insulin and epidermal growth factor (EGF) from human placental membranes, after crosslink labeling with 125I-labeled insulin and EGF, can be absorbed to an organomercurial-agarose derivative (Affi-Gel 501) and can be recovered f
Autor:
Morley D. Hollenberg, Joseph M. Maturo
Publikováno v:
Proceedings of the National Academy of Sciences. 75:3070-3074
In crude receptor preparations (either particulate or soluble) of rat liver membranes, the insulin receptor exhibits complicated binding kinetics (two binding plateaus, half-saturated at approximately 60 pM and 700 pM insulin) and an apparent chromat
Publikováno v:
Canadian Journal of Biochemistry and Cell Biology. 61:650-656
Human placental receptors for insulin and for human basic somatomedin (BSM, analogous to human insulinlike growth factor I (IGF-I)) were selectively cross-link labelled with 125I-labelled insulin and BSM using disuccinimidyl suberate under conditions
Publikováno v:
Life Sciences. 30:1973-1979
A binding molecule for L-arginine has been isolated from human placental membranes and partially characterized. It exhibits specificity for L-arginine almost exclusively with no apparent cooperativity of binding as seen by Scatchard analysis (K d = 0
Autor:
Joseph M. Maturo, Peter Rieser
Publikováno v:
Acta Diabetologica Latina. 5:31-39
The AA. report a group ofin vitro experiments relative to the direct inhibition of the insulin effect on the transport of 3-o-methyl glucose and L-proline in rat diaphragm muscle by a reagent specific for tryptophan in a neutral solution, the 2-hydro
Publikováno v:
Biochemistry. 22(10)
Autor:
Joseph M. Maturo
Publikováno v:
Endocrinology. 90(4)
A complex between tryptophan and insulin has been isolated by column chromatography. Results of the experimentation suggest that the complex is stable and that the indole ring system of tryptophan is the reactive center. A binding ratio of two molecu
Autor:
Joseph M. Maturo, Virginia Christensen
Publikováno v:
Acta diabetologica latina. 9(2)
Employing the method of gel filtration chromatography under the same conditions that an insulin-tryptophan complex has been isolated, no complex formation has been observed with cysteine or cystine.
Autor:
Peter Rieser, Joseph M. Maturo
Publikováno v:
Archives of Internal Medicine. 123:267
Specific labeling by 2-hydroxy-5-nitrobenzyl bromide (HNB) of tryptophan residues in rat diaphragms abolishes insulin stimulation of sugar and amino acid uptake, and of the incorporation of previously accumulated amino acid into muscle protein. A bri