Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Joseph M. Hyser"'
Autor:
Jacob L. Perry, Francesca J. Scribano, John T. Gebert, Kristen A. Engevik, Jenna M. Ellis, Joseph M. Hyser
Publikováno v:
mBio, Vol 15, Iss 1 (2024)
ABSTRACTRotavirus is a leading cause of viral gastroenteritis. A hallmark of rotavirus infection is increased cytosolic Ca2+ caused by nonstructural protein 4 (NSP4). NSP4 is a viral ion channel that releases endoplasmic reticulum (ER) Ca2+, and the
Externí odkaz:
https://doaj.org/article/4458c80455214920b911410df93d6fe7
Autor:
Andrea A. Hill, Myunghoo Kim, Daniel F. Zegarra-Ruiz, Lin-Chun Chang, Kendra Norwood, Adrien Assié, Wan-Jung H. Wu, Michael C. Renfroe, Hyo Wong Song, Angela M. Major, Buck S. Samuel, Joseph M. Hyser, Randy S. Longman, Gretchen E. Diehl
Publikováno v:
JCI Insight, Vol 8, Iss 3 (2023)
Chronic exposure to high-fat diets (HFD) worsens intestinal disease pathology, but acute effects of HFD in tissue damage remain unclear. Here, we used short-term HFD feeding in a model of intestinal injury and found sustained damage with increased ce
Externí odkaz:
https://doaj.org/article/4dbaf7f237bf47bcb811593b4ac7bcb2
Autor:
Melinda A. Engevik, Berkley Luck, Chonnikant Visuthranukul, Faith D. Ihekweazu, Amy C. Engevik, Zhongcheng Shi, Heather A. Danhof, Alexandra L. Chang-Graham, Anne Hall, Bradley T. Endres, Sigmund J. Haidacher, Thomas D. Horvath, Anthony M. Haag, Sridevi Devaraj, Kevin W. Garey, Robert A. Britton, Joseph M. Hyser, Noah F. Shroyer, James Versalovic
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 221-248 (2021)
Background & Aims: The human gut microbiota can regulate production of serotonin (5-hydroxytryptamine [5-HT]) from enterochromaffin cells. However, the mechanisms underlying microbial-induced serotonin signaling are not well understood. Methods: Adul
Externí odkaz:
https://doaj.org/article/104cb38cf9ef42919922904300f90cbe
Autor:
Melinda A. Engevik, Lori D. Banks, Kristen A. Engevik, Alexandra L. Chang-Graham, Jacob L. Perry, Diane S. Hutchinson, Nadim J. Ajami, Joseph F. Petrosino, Joseph M. Hyser
Publikováno v:
Gut Microbes, Vol 11, Iss 5, Pp 1324-1347 (2020)
Multiple studies have identified changes within the gut microbiome in response to diarrheal-inducing bacterial pathogens. However, examination of the microbiome in response to viral pathogens remains understudied. Compounding this, many studies use f
Externí odkaz:
https://doaj.org/article/8c2256208e634e9b87d3022a100bfe3d
Autor:
Melinda A. Engevik, Heather A. Danhof, Wenly Ruan, Amy C. Engevik, Alexandra L. Chang-Graham, Kristen A. Engevik, Zhongcheng Shi, Yanling Zhao, Colleen K. Brand, Evan S. Krystofiak, Susan Venable, Xinli Liu, Kendal D. Hirschi, Joseph M. Hyser, Jennifer K. Spinler, Robert A. Britton, James Versalovic
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
ABSTRACT Multiple studies have implicated microbes in the development of inflammation, but the mechanisms remain unknown. Bacteria in the genus Fusobacterium have been identified in the intestinal mucosa of patients with digestive diseases; thus, we
Externí odkaz:
https://doaj.org/article/ebd421ea1ed24b248d975fb71e9bd169
Autor:
Alexandra L. Chang-Graham, Heather A. Danhof, Melinda A. Engevik, Catherine Tomaro-Duchesneau, Umesh C. Karandikar, Mary K. Estes, James Versalovic, Robert A. Britton, Joseph M. Hyser
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 2, Pp 209-229 (2019)
Background & Aims: Enteroendocrine cells (EECs) are specialized epithelial cells that produce molecules vital for intestinal homeostasis, but because of their limited numbers, in-depth functional studies have remained challenging. Human intestinal en
Externí odkaz:
https://doaj.org/article/0e91d25afd634b009cf754be21479284
Autor:
Melinda A. Engevik, Beatrice Herrmann, Wenly Ruan, Amy C. Engevik, Kristen A. Engevik, Faith Ihekweazu, Zhongcheng Shi, Berkley Luck, Alexandra L. Chang-Graham, Magdalena Esparza, Susan Venable, Thomas D. Horvath, Sigmund J. Haidacher, Kathleen M. Hoch, Anthony M. Haag, Deborah A. Schady, Joseph M. Hyser, Jennifer K. Spinler, James Versalovic
Publikováno v:
Gut Microbes, Vol 13, Iss 1 (2021)
Endoplasmic reticulum (ER) stress compromises the secretion of MUC2 from goblet cells and has been linked with inflammatory bowel disease (IBD). Although Bifidobacterium can beneficially modulate mucin production, little work has been done investigat
Externí odkaz:
https://doaj.org/article/b547b2a318584a06832bccfb65d0de91
Autor:
Melinda A. Engevik, Heather A. Danhof, Ritu Shrestha, Alexandra L. Chang-Graham, Joseph M. Hyser, Anthony M. Haag, Mahmoud A. Mohammad, Robert A. Britton, James Versalovic, Joseph A. Sorg, Jennifer K. Spinler
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
Antibiotic resistance is one of the world’s greatest public health challenges and adjunct probiotic therapies are strategies that could lessen this burden. Clostridioides difficile infection (CDI) is a prime example where adjunct probiotic therapie
Externí odkaz:
https://doaj.org/article/548379f0ffcc4fa28d4b96b38d0cd042
Autor:
Alicia C. Strtak, Jacob L. Perry, Mark N. Sharp, Alexandra L. Chang-Graham, Tibor Farkas, Joseph M. Hyser
Publikováno v:
mSphere, Vol 4, Iss 5 (2019)
ABSTRACT Enteric viruses in the Caliciviridae family cause acute gastroenteritis in humans and animals, but the cellular processes needed for virus replication and disease remain unknown. A common strategy among enteric viruses, including rotaviruses
Externí odkaz:
https://doaj.org/article/7840f7771ece401b81ca0e4e0187b5d8
Autor:
Melinda A. Engevik, Berkley Luk, Alexandra L. Chang-Graham, Anne Hall, Beatrice Herrmann, Wenly Ruan, Bradley T. Endres, Zhongcheng Shi, Kevin W. Garey, Joseph M. Hyser, James Versalovic
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Much remains unknown about how the intestinal microbiome interfaces with the protective intestinal mucus layer. Bifidobacterium species colonize the intestinal mucus layer and can modulate mucus production by goblet cells. However, select Bi
Externí odkaz:
https://doaj.org/article/9df25faecc214510a661581000847ab5