Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Joseph M. Backer"'
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 10, Pp 797-806 (2010)
PURPOSE: Tumor endothelial cells express vascular endothelial growth factor receptor 2 (VEGFR-2). VEGF can direct toxins to tumor vessels through VEGFR-2 for antiangiogenic therapy. This study aimed to selectively damage the VEGFR-2-overexpressing va
Externí odkaz:
https://doaj.org/article/a10a9919a55b4d41b3dd2ba45facab90
Publikováno v:
Toxins, Vol 2, Iss 9, Pp 2242-2257 (2010)
SLT-VEGF is a recombinant cytotoxin comprised of Shiga-like toxin (SLT) subunit A fused to human vascular endothelial growth factor (VEGF). It is highly cytotoxic to tumor endothelial cells overexpressing VEGF receptor-2 (VEGFR-2/KDR/Flk1) and inhibi
Externí odkaz:
https://doaj.org/article/f072b699abdc4d2cbd9d5b72f52e8791
Autor:
Joseph M. Backer, Arcadius V. Krivoshein, Carl V. Hamby, John Pizzonia, Kenneth S. Gilbert, Yonaton S. Ray, Harrison Brand, Adrienne W. Paton, James C. Paton, Marina V. Backer
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 11, Pp 1165-1173 (2009)
Diverse physiological and therapeutic insults that increase the amount of unfolded or misfolded proteins in the endoplasmic reticulum (ER) induce the unfolded protein response, an evolutionarily conserved protective mechanism that manages ER stress.
Externí odkaz:
https://doaj.org/article/5ede904743ce4efe9eaee52357785185
Autor:
Paula Demétrio De Souza França, Jan-Philip Meyer, Tanjeena Mamun, Lukas M. Carter, Marina V. Backer, Christian Mason, Komal Mandleywala, Thomas Reiner, Jason S. Lewis, Joseph M. Backer
Publikováno v:
Molecular Imaging and Biology. 23:340-349
Metastatic breast cancer is the second leading cause of cancer-related death in women. The 5-year survival rate for metastatic breast cancer has remained near 26.9 % for over a decade. The recruitment of hematopoietic stem cells with high expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95cf4f122643169cf272d1d708597d91
https://doi.org/10.1007/s11307-020-01555-z
https://doi.org/10.1007/s11307-020-01555-z
Autor:
Ziad A. Ali, Gail E Geist, Alicia J McLuckie, Geping Zhang, Joseph M. Backer, Jordan Johnson, Lynne L. Johnson, April Holland, Yared Tekabe, Aram Safarov, Marina Backer, Rebecca A Ober
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-9 (2020)
EJNMMI Research
EJNMMI Research
Background New therapies to treat diabetic peripheral artery disease (PAD) require target-specific non-invasive imaging modalities to follow efficacy. As a translational study, we performed targeted imaging of receptors for vascular endothelial growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6b19974a0fc25db400edd1d3297c6d
http://link.springer.com/article/10.1186/s13550-020-00626-0
http://link.springer.com/article/10.1186/s13550-020-00626-0
Autor:
Ziad A. Ali, Jordan Johnson, Geping Zhang, Marina V. Backer, Joseph M. Backer, April Holland, Rebecca Ober, Lynne L. Johnson, Yared Tekabe
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Expression of receptor for advanced glycation end products (RAGE) plays an important role in diabetic peripheral artery disease. We proposed to show that treatment with an antibody blocking RAGE would improve hind limb perfusion and muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8290d6c991fc755d82784af871cea0
http://europepmc.org/articles/PMC7955479
http://europepmc.org/articles/PMC7955479
Autor:
Christian A, Mason, Lukas M, Carter, Komal, Mandleywala, Paula Demetrio, de Souza Franca, Jan-Philip, Meyer, Tanjeena, Mamun, Joseph M, Backer, Marina V, Backer, Thomas, Reiner, Jason S, Lewis
Publikováno v:
Mol Imaging Biol
PURPOSE: Metastatic breast cancer is the second leading cause of cancer-related death in women. The 5-year survival rate for metastatic breast cancer has remained near 26.9% for over a decade. The recruitment of hematopoietic stem cells with high exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b427f01adb0cfe01686357d18a849e10
https://pubmed.ncbi.nlm.nih.gov/33156495
https://pubmed.ncbi.nlm.nih.gov/33156495
Autor:
Jordan Johnson, Joseph M. Backer, Marina V. Backer, Qing Li, Ann Marie Schmidt, Lynne L. Johnson, Geping Zhang, Yared Tekabe
Publikováno v:
Molecular Imaging and Biology. 20:963-972
To compare targeted imaging of vascular endothelial growth factor (VEGF) receptors vs. αvβ3 integrins in a mouse hindlimb ischemia model of peripheral artery disease. Male wild-type (WT) C57BL/6 mice (8- to 10-week old) (n = 24) underwent left femo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fdb3e4b11564871a9147f8a7e887b72
https://doi.org/10.1007/s11307-018-1191-1
https://doi.org/10.1007/s11307-018-1191-1
Autor:
Krissy Rodriquez, Lynne L. Johnson, Joseph M. Backer, Qing Li, Yared Tekabe, Marina V. Backer
Publikováno v:
Molecular Imaging and Biology. 20:85-93
Plaque vulnerability is associated with inflammation and angiogenesis, processes that rely on vascular endothelial growth factor (VEGF) signaling via two receptors, VEGFR-1 and VEGFR-2. We have recently reported that enhanced uptake of scVEGF-PEG-DOT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce91d66885b9204cf10a17f389296c5
https://doi.org/10.1007/s11307-017-1045-2
https://doi.org/10.1007/s11307-017-1045-2
Autor:
Olga Shenderova, Marina V. Backer, Daria S Filonov, Ashlyn G. Rickard, Alexander V. Kinev, Nicholas Nunn, Joseph M. Backer, Marco D. Torelli, Gregory M. Palmer
Publikováno v:
Bioconjug Chem
The increased expression of vascular endothelial growth factor (VEGF) and its receptors is associated with angiogenesis in a growing tumor, presenting potential targets for tumor-selective imaging by way of targeted tracers. Though fluorescent tracer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9afbeb8d27575a69282983a2f39815a
https://europepmc.org/articles/PMC7605622/
https://europepmc.org/articles/PMC7605622/
