Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Joseph M Chan"'
Autor:
Alvaro Quintanal-Villalonga, Kenta Kawasaki, Esther Redin, Fathema Uddin, Swanand Rakhade, Vidushi Durani, Amin Sabet, Moniquetta Shafer, Wouter R. Karthaus, Samir Zaidi, Yingqian A. Zhan, Parvathy Manoj, Harsha Sridhar, Dennis Kinyua, Hong Zhong, Barbara P. Mello, Metamia Ciampricotti, Umesh K. Bhanot, Irina Linkov, Juan Qiu, Radhika A. Patel, Colm Morrissey, Sanjoy Mehta, Jesse Barnes, Michael C. Haffner, Nicholas D. Socci, Richard P. Koche, Elisa de Stanchina, Sonia Molina-Pinelo, Sohrab Salehi, Helena A. Yu, Joseph M. Chan, Charles M. Rudin
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract Neuroendocrine (NE) transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor prognosis. Up to date, even if patients at high risk of transformation can be identified by the occurren
Externí odkaz:
https://doaj.org/article/501fe4c8a5e9423ca573e0d9f455d0b2
Autor:
Hirokazu Taniguchi, Shweta S. Chavan, Andrew Chow, Joseph M. Chan, Hiroshi Mukae, Charles M. Rudin, Triparna Sen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionImmune checkpoint blockade (ICB) with or without chemotherapy has a very modest benefit in patients with small cell lung cancer (SCLC). SCLC tumors are characterized by high tumor mutation burden (TMB) and low PD-L1 expression. Therefore,
Externí odkaz:
https://doaj.org/article/868c6a6e68f04b8d9bd28b2cfda79613
Autor:
Alvaro Quintanal-Villalonga, Hirokazu Taniguchi, Yingqian A. Zhan, Maysun M. Hasan, Shweta S. Chavan, Fanli Meng, Fathema Uddin, Viola Allaj, Parvathy Manoj, Nisargbhai S. Shah, Joseph M. Chan, Metamia Ciampricotti, Andrew Chow, Michael Offin, Jordana Ray-Kirton, Jacklynn D. Egger, Umesh K. Bhanot, Irina Linkov, Marina Asher, Michael H. Roehrl, Katia Ventura, Juan Qiu, Elisa de Stanchina, Jason C. Chang, Natasha Rekhtman, Brian Houck-Loomis, Richard P. Koche, Helena A. Yu, Triparna Sen, Charles M. Rudin
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-19 (2021)
Abstract Background Lineage plasticity, the ability to transdifferentiate among distinct phenotypic identities, facilitates therapeutic resistance in cancer. In lung adenocarcinomas (LUADs), this phenomenon includes small cell and squamous cell (LUSC
Externí odkaz:
https://doaj.org/article/4c6ed1ab46b04936a848bae9af7bc67d
Autor:
Álvaro Quintanal-Villalonga, Joseph M. Chan, Ignas Masilionis, Vianne Ran Gao, Yubin Xie, Viola Allaj, Andrew Chow, John T. Poirier, Dana Pe’er, Charles M. Rudin, Linas Mazutis
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101776- (2022)
Summary: We report a protocol for obtaining high-quality single-cell transcriptomics data from human lung biospecimens acquired from core needle biopsies, fine-needle aspirates, surgical resection, and pleural effusions. The protocol relies upon the
Externí odkaz:
https://doaj.org/article/237874114b8a404ab1b404381e5e804b
Autor:
Joseph M. Chan, Samir Zaidi, Jillian R. Love, Jimmy L. Zhao, Manu Setty, Kristine M. Wadosky, Anuradha Gopalan, Zi-Ning Choo, Sitara Persad, Jungmin Choi, Justin LaClair, Kayla E. Lawrence, Ojasvi Chaudhary, Tianhao Xu, Ignas Masilionis, Irina Linkov, Shangqian Wang, Cindy Lee, Afsar Barlas, Michael J. Morris, Linas Mazutis, Ronan Chaligne, Yu Chen, David W. Goodrich, Wouter R. Karthaus, Dana Pe’er, Charles L. Sawyers
Publikováno v:
Science
Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the molecular mechanisms driving this plasticity remain unclear. Using murine organoid and genetically engineered mouse models, we investigated the causes of lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67dc0219b760014ba836a35febf50293
https://doi.org/10.1126/science.abn0478
https://doi.org/10.1126/science.abn0478
Autor:
Triparna Sen, Charles M. Rudin, Richard P. Koche, Brian Loomis, John T. Poirier, Natasha Rekhtman, Marina K. Baine, Elisa de Stanchina, Juan Qiu, Helena A. Yu, Travis J. Hollmann, Michael H. Roehrl, Christine A. Iacobuzio-Donahue, Joachim Silber, Sonali Sinha, Marina Asher, Irina Linkov, Umesh K. Bhanot, Jacklynn Egger, Sam E. Tischfield, Jordana Ray-Kirton, Jason C. Chang, Michael Offin, Andrew Chow, Metamia Ciampricotti, Joseph M. Chan, Helen H. Won, Mark T.A. Donoghue, Parvathy Manoj, Fathema Uddin, Fanli Meng, Shweta S. Chavan, Maysun M. Hasan, Yingqian A. Zhan, Hirokazu Taniguchi, Alvaro Quintanal-Villalonga
Supplemental tables S1-S15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b59aeae9efc033bbf7f750d12903ac3
https://doi.org/10.1158/2159-8290.22540718
https://doi.org/10.1158/2159-8290.22540718
Autor:
Triparna Sen, Charles M. Rudin, Richard P. Koche, Brian Loomis, John T. Poirier, Natasha Rekhtman, Marina K. Baine, Elisa de Stanchina, Juan Qiu, Helena A. Yu, Travis J. Hollmann, Michael H. Roehrl, Christine A. Iacobuzio-Donahue, Joachim Silber, Sonali Sinha, Marina Asher, Irina Linkov, Umesh K. Bhanot, Jacklynn Egger, Sam E. Tischfield, Jordana Ray-Kirton, Jason C. Chang, Michael Offin, Andrew Chow, Metamia Ciampricotti, Joseph M. Chan, Helen H. Won, Mark T.A. Donoghue, Parvathy Manoj, Fathema Uddin, Fanli Meng, Shweta S. Chavan, Maysun M. Hasan, Yingqian A. Zhan, Hirokazu Taniguchi, Alvaro Quintanal-Villalonga
Lineage plasticity is implicated in treatment resistance in multiple cancers. In lung adenocarcinomas (LUAD) amenable to targeted therapy, transformation to small cell lung cancer (SCLC) is a recognized resistance mechanism. Defining molecular mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19866bcbfca6f0bd1b206c8dae81ff58
https://doi.org/10.1158/2159-8290.c.6549461
https://doi.org/10.1158/2159-8290.c.6549461
Autor:
Triparna Sen, Charles M. Rudin, Richard P. Koche, Brian Loomis, John T. Poirier, Natasha Rekhtman, Marina K. Baine, Elisa de Stanchina, Juan Qiu, Helena A. Yu, Travis J. Hollmann, Michael H. Roehrl, Christine A. Iacobuzio-Donahue, Joachim Silber, Sonali Sinha, Marina Asher, Irina Linkov, Umesh K. Bhanot, Jacklynn Egger, Sam E. Tischfield, Jordana Ray-Kirton, Jason C. Chang, Michael Offin, Andrew Chow, Metamia Ciampricotti, Joseph M. Chan, Helen H. Won, Mark T.A. Donoghue, Parvathy Manoj, Fathema Uddin, Fanli Meng, Shweta S. Chavan, Maysun M. Hasan, Yingqian A. Zhan, Hirokazu Taniguchi, Alvaro Quintanal-Villalonga
Supplemental figures and figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cdf6100787567edd1d3c55a0d31bc8
https://doi.org/10.1158/2159-8290.22540724
https://doi.org/10.1158/2159-8290.22540724
Autor:
David J. Kennedy, Joseph M. Chan, Dinkar Kaw, Anand M. Ravindaran, Shobha Ratnam, Deepak Malhotra, Joseph I. Shapiro
Publikováno v:
Marshall Journal of Medicine, Vol 2, Iss 2, Pp 54-68 (2016)
Background: Urinalysis is an important component in the assessment of acute kidney injury (AKI). Proteonomics is a rapidly developing approach in the analysis of physiological states. Several techniques have been developed to screen for protein popul
Externí odkaz:
https://doaj.org/article/fcfd4deb1db04f7ca118528abbe423ab
Autor:
J. Qiu, Umesh Bhanot, John T. Poirier, Yingqian Zhan, Elisa de Stanchina, Viola Allaj, Hirokazu Taniguchi, Fathema Uddin, Travis J. Hollmann, Jordana Ray-Kirton, Metamia Ciampricotti, Andrew Chow, Marina Asher, Richard Koche, Álvaro Quintanal-Villalonga, Jacklynn V. Egger, Yuan Hao, Joseph M. Chan, Shweta S Chavan, Charles M. Rudin, Michael H.A. Roehrl, Triparna Sen, Michael Offin, Irina Linkov, Nisargbhai S. Shah, P. Manoj
Publikováno v:
Cancer Res
Small cell lung cancer (SCLC) is an aggressive malignancy characterized by early metastasis and extreme lethality. The backbone of SCLC treatment over the past several decades has been platinum-based doublet chemotherapy, with the recent addition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a692c156818598d92dc7462e2763c1d7
https://doi.org/10.1158/0008-5472.can-21-2964
https://doi.org/10.1158/0008-5472.can-21-2964