Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Joseph M, Wallace"'
Sex-specific trisomic Dyrk1a-related skeletal phenotypes during development in a Down syndrome model
Autor:
Jonathan M. LaCombe, Kourtney Sloan, Jared R. Thomas, Matthew P. Blackwell, Isabella Crawford, Flannery Bishop, Joseph M. Wallace, Randall J. Roper
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 9 (2024)
Externí odkaz:
https://doaj.org/article/1572a482389742a1848b82c57d5c59f0
Autor:
Rachel Kohler, Dyann M. Segvich, Olivia Reul, Corinne E. Metzger, Matthew R. Allen, Joseph M. Wallace
Publikováno v:
Bone Reports, Vol 21, Iss , Pp 101774- (2024)
As international incidence of diabetes and diabetes-driven comorbidities such as chronic kidney disease (CKD) continue to climb, interventions are needed that address the high-risk skeletal fragility of what is a complex disease state. Romosozumab (R
Externí odkaz:
https://doaj.org/article/f2fef5bde2ff4c53b286fc3ce44d9e71
Autor:
Padmini Deosthale, Julián Balanta-Melo, Amy Creecy, Chongshan Liu, Alejandro Marcial, Laura Morales, Julita Cridlin, Sylvia Robertson, Chiebuka Okpara, David J. Sanchez, Mahdi Ayoubi, Joaquín N. Lugo, Christopher J. Hernandez, Joseph M. Wallace, Lilian I. Plotkin
Publikováno v:
Bone Research, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene mutations lead to fragile X syndrome, cognitive disorders, and, in some individuals, scoliosis and craniofacial abnormalities. Four-month-old (mo) male mice with deletion of the FMR1 gene e
Externí odkaz:
https://doaj.org/article/a417505826a14e3a95c728e6a4fe1270
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Bone is a hierarchical material formed by an organic extracellular matrix and mineral where each component and their physical relationship with each other contribute to fracture resistance. Bone quality can be affected by nutrition, and diet
Externí odkaz:
https://doaj.org/article/0223fc78ff124ebc8e2f8e53641e41fc
Autor:
Kourtney Sloan, Jared Thomas, Matthew Blackwell, Deanna Voisard, Eva Lana-Elola, Sheona Watson-Scales, Daniel L. Roper, Joseph M. Wallace, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz, Randall J. Roper
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 4 (2023)
Externí odkaz:
https://doaj.org/article/3bbbbb9016c543a4b1f805a022884fdf
Publikováno v:
Bone Reports, Vol 17, Iss , Pp 101609- (2022)
Diabetes Mellitus is a metabolic disease which profoundly affects many organ systems in the body, including the skeleton. As is often the case with biology, there are inherent differences between the sexes when considering skeletal development and di
Externí odkaz:
https://doaj.org/article/8c73847cd5e04060a8d10b4d37717228
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Estrogen agonist raloxifene is an FDA-approved treatment of osteoporosis in postmenopausal women, which may also be a promising prophylactic for painful intervertebral disc (IVD) degeneration. Here, we hypothesized that 1) aging and biological sex co
Externí odkaz:
https://doaj.org/article/7b92e75c276740d1a6247b33a7c45dd5
Publikováno v:
Bone Reports, Vol 16, Iss , Pp 101161- (2022)
Water constitutes roughly a quarter of the cortical bone by volume yet can greatly influence mechanical properties and tissue quality. There is a growing appreciation for how water can dynamically change due to age, disease, and treatment. A key emer
Externí odkaz:
https://doaj.org/article/c8248af570b64d849dba367b35b4c18b
Autor:
Elizabeth A. Swallow, Corinne E. Metzger, Neal X. Chen, Joseph M. Wallace, Samantha P. Tippen, Rachel Kohler, Sharon M. Moe, Matthew R. Allen
Publikováno v:
Bone Reports, Vol 16, Iss , Pp 101174- (2022)
Purpose: Patients with chronic kidney disease (CKD) have high risk of fracture in part due to cortical bone deterioration. The goal of this study was to assess the impact of two different bisphosphonates and dosing regimens on cortical microstructure
Externí odkaz:
https://doaj.org/article/478176b5d8024c828717f335f95c00ea
Autor:
Michael P. Liesen, Megan L. Noonan, Pu Ni, Rafiou Agoro, Julia M. Hum, Erica L. Clinkenbeard, John G. Damrath, Joseph M. Wallace, Elizabeth A. Swallow, Matthew R. Allen, Kenneth E. White
Publikováno v:
Physiological Reports, Vol 10, Iss 11, Pp n/a-n/a (2022)
Abstract Ferric citrate (FC) is an approved therapy for chronic kidney disease (CKD) patients as a phosphate (Pi) binder for dialysis‐dependent CKD, and for iron deficiency anemia (IDA) in non‐dialysis CKD. Elevated Pi and IDA both lead to increa
Externí odkaz:
https://doaj.org/article/d97139ec9c584ca49c400a203575d55c