Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Joseph M, Rifkind"'
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/fbfc82881ee24c34a4d82187dd7dfad8
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
The primary role for erythrocytes is oxygen transport that requires the reversible binding of oxygen to hemoglobin. There are, however, secondary reactions whereby the erythrocyte can generate reactive oxygen species (ROS) and nitric oxide (NO). ROS
Externí odkaz:
https://doaj.org/article/966736cc5b4e4286bdf9cfa6bb575269
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Red blood cell (RBC) deformability has a significant impact on microcirculation by affecting cell dynamics. Despite previous studies that have demonstrated the margination of rigid cells and particles in vitro, little information is available on the
Externí odkaz:
https://doaj.org/article/1f39e1a1c9e04e0a97e5462d5d396078
Publikováno v:
Frontiers in Physiology, Vol 5 (2015)
Hemoglobin (Hb) continuously undergoes autoxidation producing superoxide which dismutates into hydrogen peroxide (H2O2) and is a potential source for subsequent oxidative reactions. Autoxidation is most pronounced under hypoxic conditions in the micr
Externí odkaz:
https://doaj.org/article/2519714b37dd4c9b8eea0e2def5e6e8f
Autor:
Luke B. Ravi, Suresh Poosala, Dongchoon Ahn, Francis J. Chrest, Edward L. Spangler, Rajadas Jayakumar, Enika Nagababu, Joy G. Mohanty, Mark Talan, Donald K. Ingram, Joseph M. Rifkind
Publikováno v:
Neurobiology of Disease, Vol 19, Iss 1, Pp 28-37 (2005)
Vascular amyloidosis in Alzheimer's disease (AD) results in the exposure of red blood cells to β-amyloid fibrils (Aβ). The potential in vivo ramifications of this exposure have been investigated by injecting Aβ1–40 alone or Aβ-bound mouse red b
Externí odkaz:
https://doaj.org/article/306fa1039dd0455dbd0e1cb2d0f9cdde
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Red Blood Cells (RBCs) need to deform and squeeze through narrow capillaries. Thus, decreased deformability of RBCs contributes to the elimination of aged or damaged RBCs from the circulation. This process causes impaired oxygen delivery, which has c
Externí odkaz:
https://doaj.org/article/ef8073af266e4098a71417d5d4fca674
Autor:
Jayakumar Rajadas, Wenchao Sun, Hai Li, Mohammed Inayathullah, Damiano Cereghetti, Aaron Tan, Valeria de Mello Coelho, Francis J Chrest, John W Kusiak, Wanli Wei Smith, Dennis Taub, Joseph C Wu, Joseph M Rifkind
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58194 (2013)
Amyloid accumulation in the brain of Alzheimer's patients results from altered processing of the 39- to 43-amino acid amyloid β protein (Aβ). The mechanisms for the elevated amyloid (Aβ(1-42)) are considered to be over-expression of the amyloid pr
Externí odkaz:
https://doaj.org/article/ad5b4c0d728d4f8abc1ada75903b5396
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
The primary role for erythrocytes is oxygen transport that requires the reversible binding of oxygen to hemoglobin. There are, however, secondary reactions whereby the erythrocyte can generate reactive oxygen species (ROS) and nitric oxide (NO). ROS
Publikováno v:
Biochemistry. 54:6712-6723
The reduction of nitrite by deoxyhemoglobin to nitric oxide (NO) has been proposed as a mechanism for the transfer of NO bioactivity from the red blood cell (RBC) to the vasculature. This transfer can increase vascular dilatation. The major challenge