Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Joseph M, McClung"'
Autor:
Hasan Abbas, Lindsey A. Olivere, Michael E. Padgett, Cameron A. Schmidt, Brian F. Gilmore, Timothy J. McCord, Kevin W. Southerland, Joseph M. McClung, Christopher D. Kontos
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Skeletal muscle injury in peripheral artery disease (PAD) has been attributed to vascular insufficiency, however evidence has demonstrated that muscle cell responses play a role in determining outcomes in limb ischemia. Here, we demonstrate that gene
Externí odkaz:
https://doaj.org/article/a35bd435f70c4f4abab32ab71391c845
Autor:
Everett C. Minchew, Nicholas C. Williamson, Andrew T. Readyoff, Joseph M. McClung, Espen E. Spangenburg
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Assessing contractile function of skeletal muscle in murine models is a commonly employed laboratory technique that investigators utilize to measure the impact of genetic manipulations, drug efficacy, or other therapeutic interventions. Often overloo
Externí odkaz:
https://doaj.org/article/fc1799cf75904eaaa784ffb41e12a882
Autor:
Melissa R. Iñigo, Adam J. Amorese, Michael D. Tarpey, Nicholas P. Balestrieri, Keith G. Jones, Daniel J. Patteson, Kathryn C. Jackson, Maria.J. Torres, Chien-Te Lin, Cody D. Smith, Timothy D. Heden, Shawna L. McMillin, Luke A. Weyrauch, Erin C. Stanley, Cameron A. Schmidt, Brita B. Kilburg-Basnyat, Sky W. Reece, Christine E. Psaltis, Leslie A. Leinwand, Katsu Funai, Joseph M. McClung, Kymberly M. Gowdy, Carol A. Witczak, Dawn A. Lowe, P. Darrell Neufer, Espen E. Spangenburg
Publikováno v:
Molecular Metabolism, Vol 34, Iss , Pp 1-15 (2020)
Objective: Estrogen receptor-α (ERα) is a nuclear receptor family member thought to substantially contribute to the metabolic regulation of skeletal muscle. However, previous mouse models utilized to assess the necessity of ERα signaling in skelet
Externí odkaz:
https://doaj.org/article/cef6092a71cd44739e7411b85eb621c4
Autor:
Terence E. Ryan, Kyoungrae Kim, Salvatore T. Scali, Scott A. Berceli, Trace Thome, Zachary R. Salyers, Kerri A. O'Malley, Thomas D. Green, Reema Karnekar, Kelsey H. Fisher‐Wellman, Dean J. Yamaguchi, Joseph M. McClung
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 1, Pp n/a-n/a (2022)
Abstract Background Despite improved surgical approaches for chronic limb‐threatening ischemia (CLTI), amputation rates remain high and contributing tissue‐level factors remain unknown. The purpose of this study was twofold: (1) to identify diffe
Externí odkaz:
https://doaj.org/article/36099b1af26a45dd90c17d365887f066
Autor:
Margaret AM Nelson, Kelsey L McLaughlin, James T Hagen, Hannah S Coalson, Cameron Schmidt, Miki Kassai, Kimberly A Kew, Joseph M McClung, P Darrell Neufer, Patricia Brophy, Nasreen A Vohra, Darla Liles, Myles C Cabot, Kelsey H Fisher-Wellman
Publikováno v:
eLife, Vol 10 (2021)
Currently there is great interest in targeting mitochondrial oxidative phosphorylation (OXPHOS) in cancer. However, notwithstanding the targeting of mutant dehydrogenases, nearly all hopeful ‘mito-therapeutics’ cannot discriminate cancerous from
Externí odkaz:
https://doaj.org/article/e567853a8a3040149b87851b0c1938d3
Autor:
Terence E. Ryan, Cameron A. Schmidt, Michael D. Tarpey, Adam J. Amorese, Dean J. Yamaguchi, Emma J. Goldberg, Melissa M.R. Iñigo, Reema Karnekar, Allison O’Rourke, James M. Ervasti, Patricia Brophy, Thomas D. Green, P. Darrell Neufer, Kelsey Fisher-Wellman, Espen E. Spangenburg, Joseph M. McClung
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
Compromised muscle mitochondrial metabolism is a hallmark of peripheral arterial disease, especially in patients with the most severe clinical manifestation — critical limb ischemia (CLI). We asked whether inflexibility in metabolism is critical fo
Externí odkaz:
https://doaj.org/article/ae9840111eff4cc6b769461964faa51a
Autor:
Michael D. Tarpey, Adam J. Amorese, Nicholas P. Balestrieri, Terence E. Ryan, Cameron A. Schmidt, Joseph M. McClung, Espen E. Spangenburg
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Background The ability to assess skeletal muscle function and delineate regulatory mechanisms is essential to uncovering therapeutic approaches that preserve functional independence in a disease state. Skeletal muscle provides distinct exper
Externí odkaz:
https://doaj.org/article/aaa78d16888d477bb0e9fb04b22212fc
Autor:
Valerie D. Myers, MS, Joseph M. McClung, PhD, JuFang Wang, MD, Farzaneh G. Tahrir, PhD, Manish K. Gupta, PhD, Jennifer Gordon, PhD, Christopher H. Kontos, MD, Kamel Khalili, PhD, Joseph Y. Cheung, MD, PhD, Arthur M. Feldman, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 1, Pp 122-131 (2018)
The B-cell lymphoma 2–associated anthanogene (BAG3) protein is expressed most prominently in the heart, the skeletal muscle, and in many forms of cancer. In the heart, it serves as a co-chaperone with heat shock proteins in facilitating autophagy;
Externí odkaz:
https://doaj.org/article/33d9e8f9566344c191444dc53631ac00
Autor:
Cameron A Schmidt, Emma J Goldberg, Tom D Green, Reema R Karnekar, Jeffrey J Brault, Spencer G Miller, Adam J Amorese, Dean J Yamaguchi, Espen E Spangenburg, Joseph M McClung
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0225922 (2020)
Stored muscle carbohydrate supply and energetic efficiency constrain muscle functional capacity during exercise and are influenced by common physiological variables (e.g. age, diet, and physical activity level). Whether these constraints affect overa
Externí odkaz:
https://doaj.org/article/3f3a933d89974689ad73794a5bb1e8f2
Autor:
Emma J. Goldberg, Cameron A. Schmidt, T. D. Green, R. Karnekar, D. J. Yamaguchi, E. E. Spangenberg, Joseph M. McClung
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
During incomplete skeletal muscle recovery from ischemia, such as that occurs with critical limb ischemia, the temporal relationship between recovery of muscle capillary perfusion and contractile function is poorly defined. We examined this relations
Externí odkaz:
https://doaj.org/article/5b1f5209d4714b14b56ad594c204a3d0