Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Joseph M, Courtney"'
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(26)
Accurate measurements of the size and quantity of aerosols generated by various human activities in different environments are required for efficacious mitigation strategies and accurate modeling of respiratory disease transmission. Previous studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d4b0a992a31c931b244e299c0ddee5
https://pubmed.ncbi.nlm.nih.gov/35727979
https://pubmed.ncbi.nlm.nih.gov/35727979
Publikováno v:
Journal of the American Chemical Society
The 68-kDa homodimeric 3C-like protease of SARS-CoV-2, Mpro (3CLpro/Nsp5), is a promising antiviral drug target. We evaluate the concordance of models generated by the newly introduced AlphaFold2 structure prediction program with residual dipolar cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58297549e64d65d8151919315379b097
Autor:
Ad Bax, Joseph M. Courtney
Seasonality of respiratory diseases has been linked, among other factors, to low outdoor absolute humidity and low relative humidity in indoor environments, which increase evaporation of water in the mucosal layer lining the respiratory tract. We dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f84462a7e734b36e68fbd43630db646
https://doi.org/10.1101/2020.12.23.20248671
https://doi.org/10.1101/2020.12.23.20248671
Publikováno v:
The Journal of Physical Chemistry B. 122:11792-11799
Previous pressure-jump NMR experiments on a pressure-sensitized double mutant of ubiquitin showed evidence that its folding occurs via two parallel, comparably efficient pathways: A single barrier and a two-barrier pathway. An interrupted folding NMR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6914cf93e2b62a781df5a47348f06674
https://doi.org/10.1021/acs.jpcb.8b08456
https://doi.org/10.1021/acs.jpcb.8b08456
Publikováno v:
Journal of the American Chemical Society. 140:8096-8099
Pressure-jump hardware permits direct observation of protein NMR spectra during a cyclically repeated protein folding process. For a two-state folding protein, the change in resonance frequency will occur nearly instantaneously when the protein clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e3deb5f18b9560aeda304ec3285c5e
https://doi.org/10.1021/jacs.8b04833
https://doi.org/10.1021/jacs.8b04833
Autor:
Chad M. Rienstra, Joseph M. Courtney, Dhruva Dhavale, Paul T. Kotzbauer, Alexander M. Barclay
Publikováno v:
Biomolecular NMR Assignments. 12:195-199
Fibrils of the protein α-synuclein are implicated in the pathogenesis of Parkinson’s disease and related neurodegenerative disorders. We have reported a high-resolution structure (PDB 2N0A) of an α-synuclein fibril form prepared by in vitro incub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78642f0b5fc9368d9e7185bd71872149
https://doi.org/10.1007/s12104-018-9808-5
https://doi.org/10.1007/s12104-018-9808-5
Autor:
T. Reid Alderson, Philip A. Anfinrud, Adriaan Bax, Joseph M. Courtney, Cyril Charlier, Jinfa Ying
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Development of specialized instrumentation enables rapid switching of the hydrostatic pressure inside an operating NMR spectrometer. This technology allows observation of protein signals during the repeated folding process. Applied to ub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d89649a0c90cb19e4f5a80814c666413
https://doi.org/10.1073/pnas.1803642115
https://doi.org/10.1073/pnas.1803642115
Autor:
Alexander G. Cioffi, Chad M. Rienstra, Martin D. Burke, Dennis W. Piehl, Joseph M. Courtney, Zoe A. Petros, Lisa A. Della Ripa
Cholesterol (Chol) is vital for cell function as it is essential to a myriad of biochemical and biophysical processes. The atomistic details of Chol’s interactions with phospholipids and proteins is therefore of fundamental interest, and NMR offers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66e06b052d8d0366d6162f14cfcaa09
https://europepmc.org/articles/PMC6003781/
https://europepmc.org/articles/PMC6003781/
Publikováno v:
Biophysical Journal. 116:338a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2573da8e3cd2fc41a929455a0a6552ba
https://doi.org/10.1016/j.bpj.2018.11.1841
https://doi.org/10.1016/j.bpj.2018.11.1841
Autor:
Joseph M. Courtney, Chad M. Rienstra
We present a systematic study of dipolar double quantum (DQ) filtering in 13 C-labeled organic solids over a range of magic-angle spinning rates, using the SPC- n recoupling sequence element with a range of n symmetry values from 3 to 11. We find tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bedc54a271ea37878432aabfd9012846
https://europepmc.org/articles/PMC5019030/
https://europepmc.org/articles/PMC5019030/