Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Joseph M, Collins"'
Autor:
Annemarie Lang, Andreas Benn, Joseph M. Collins, Angelique Wolter, Tim Balcaen, Greet Kerckhofs, An Zwijsen, Joel D. Boerckel
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Skeletal development depends on coordinated angiogenesis and osteogenesis. Bone morphogenetic proteins direct bone formation in part by activating SMAD1/5 signaling in osteoblasts. However, the role of SMAD1/5 in skeletal endothelium is unkn
Externí odkaz:
https://doaj.org/article/3c3f2b0dd6834e6782d3048a6c987169
Autor:
Joseph M. Collins, Danxin Wang
Publikováno v:
Molecules, Vol 29, Iss 22, p 5407 (2024)
CYP3As are important drug-metabolizing enzymes in the liver. The causes for large inter-person variability in CYP3A expression/activity remain poorly understood. DNA methylation broadly regulates gene expression and the developmental transition from
Externí odkaz:
https://doaj.org/article/a0feb471687f49d68f8827995fdea54e
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 6, Pp n/a-n/a (2023)
Abstract UDP‐glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that play important roles in the detoxification of endogenous and exogenous substrates. The 22 human UGTs belong to four families (UGT1, UGT2, UGT3, and UGT8) and d
Externí odkaz:
https://doaj.org/article/b7e1806d977a4c29aed3ad57c9b6d818
Autor:
Joseph M. Collins, Adaeze C. Nworu, Somayya J. Mohammad, Liang Li, Chengcheng Li, Chuanjiang Li, Ethan Schwendeman, Mattew Cefalu, Mahmoud Abdel‐Rasoul, Jessie W. Sun, Sakima A. Smith, Danxin Wang
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 11, Pp 2720-2731 (2022)
Abstract The cytochrome P450 3As (CYP3As) are abundantly expressed in the liver and metabolize many commonly prescribed medications. Their expression is highly variable between individuals with little known genetic cause. Despite extensive investigat
Externí odkaz:
https://doaj.org/article/5d55e8a7d4bc4d709515918da4fc7d27
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
CYP2D6 is one of the most polymorphic drug-metabolizing enzymes in the liver. While genetic CYP2D6 variants serve as clinical biomarkers to predict CYP2D6 activity, large inter-person variability in CYP2D6 expression remains unaccounted for. Previous
Externí odkaz:
https://doaj.org/article/106ce48ef9114f248d56934fc3334d82
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Cytochrome P450 (CYP) drug metabolizing enzymes are responsible for the metabolism of over 70% of currently used medications with the CYP3A family being the most important CYP enzymes in the liver. Large inter-person variability in expression/activit
Externí odkaz:
https://doaj.org/article/91ba945ccbae4a00a11c0758c7d29214
Autor:
Li-Qun Chen, Shweta Chhajed, Tong Zhang, Joseph M. Collins, Qiuying Pang, Wenyuan Song, Yan He, Sixue Chen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract During the past two decades, glucosinolate (GLS) metabolic pathways have been under extensive studies because of the importance of the specialized metabolites in plant defense against herbivores and pathogens. The studies have led to a nearl
Externí odkaz:
https://doaj.org/article/58ab62216ba94c8e9ead76082433e2ef
Publikováno v:
Molecules, Vol 26, Iss 19, p 5934 (2021)
Veratrum spp. grow throughout the world and are especially prevalent in high mountain meadows of North America. All parts of Veratrum plants have been used for the treatment of ailments including injuries, hypertension, and rheumatic pain since as fa
Externí odkaz:
https://doaj.org/article/8cf758334d91451e97245aac17af52c9
Autor:
Mark M. Skinner, Jared T. Seale, Maranda S. Cantrell, Joseph M. Collins, Matthew W. Turner, Owen M. McDougal
Publikováno v:
Foods, Vol 10, Iss 9, p 2038 (2021)
The purpose of this experimental review was to detect acrylamide in French fries using methods most adaptable to the food process industry for quality control assessment of products. French fries were prepared at different cook times using the same f
Externí odkaz:
https://doaj.org/article/193fc3e8d9624541836e3fbd54319169
Publikováno v:
Case Reports in Neurological Medicine, Vol 2019 (2019)
Opsoclonus myoclonus syndrome (OMS) is an extremely rare neurological syndrome typically affecting as few as 1 in 10,000,000 people annually. OMS is characterized by the presence of involuntary, saccadic eye movements, as well as ataxia, including ga
Externí odkaz:
https://doaj.org/article/2a5024c4505c483fb4fa5b289ba25b9f