Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Joseph M, Chambers"'
Publikováno v:
AIMS Molecular Science, Vol 8, Iss 4, Pp 202-222 (2021)
Alcohol and opioid abuse have pervasive and detrimental consequences from the individual to societal level. The extent of genetic contribution to alcoholism has been studied for decades, yielding speculative and often inconsistent results since the p
Externí odkaz:
https://doaj.org/article/f585d1bb3b674cd6b6368d2f024c6af9
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273582 (2022)
The number of adverse drug events in the United States is critically high, with annual rates exceeding 1 million cases over the last nine years. One cause of adverse drug events is the underlying genetic variation that can alter drug responses. Pharm
Externí odkaz:
https://doaj.org/article/ade4048d29084239b105252ee3256a9c
Autor:
Hannah M. Wesselman, Thanh Khoa Nguyen, Joseph M. Chambers, Bridgette E. Drummond, Rebecca A. Wingert
Publikováno v:
Journal of Developmental Biology, Vol 11, Iss 1, p 1 (2022)
Cilia are microtubule-based organelles that project from the cell surface. In humans and other vertebrates, possession of a single cilium structure enables an assortment of cellular processes ranging from mechanosensation to fluid propulsion and loco
Externí odkaz:
https://doaj.org/article/8109c033b56a49189bec804650d1e4a6
Publikováno v:
AIMS Bioengineering, Vol 3, Iss 3, Pp 305-318 (2016)
The kidney is a complex organ whose excretory and regulatory functions are vital for maintaining homeostasis. Previous techniques used to study the kidney, including various animal models and 2D cell culture systems to investigate the mechanisms of r
Externí odkaz:
https://doaj.org/article/f6721db86dba455d985f355c68dd46d3
Autor:
Joseph M. Chambers, Rebecca A. Wingert
Publikováno v:
Cells, Vol 9, Iss 10, p 2234 (2020)
Peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α) is perhaps best known as a master regulator of mitochondrial biogenesis and function. However, by virtue of its interactions as a coactivator for numerous nuclear recepto
Externí odkaz:
https://doaj.org/article/94e9ca01c3984cd697a5463e949c593e
Autor:
Joseph M Chambers, Shahram Jevin Poureetezadi, Amanda Addiego, Manuela Lahne, Rebecca A Wingert
Publikováno v:
eLife, Vol 7 (2018)
Nephron segmentation involves a concert of genetic and molecular signals that are not fully understood. Through a chemical screen, we discovered that alteration of peroxisome proliferator-activated receptor (PPAR) signaling disrupts nephron segmentat
Externí odkaz:
https://doaj.org/article/9da626ac8c884c84b4f0d344bce86300
Autor:
Shahram Jevin Poureetezadi, Christina N Cheng, Joseph M Chambers, Bridgette E Drummond, Rebecca A Wingert
Publikováno v:
eLife, Vol 5 (2016)
Kidney formation involves patterning events that induce renal progenitors to form nephrons with an intricate composition of multiple segments. Here, we performed a chemical genetic screen using zebrafish and discovered that prostaglandins, lipid medi
Externí odkaz:
https://doaj.org/article/9d938038c98e4d3385edf849f9c616f3
Publikováno v:
AIMS Molecular Science, Vol 8, Iss 4, Pp 202-222 (2021)
Alcohol and opioid abuse have pervasive and detrimental consequences from the individual to societal level. The extent of genetic contribution to alcoholism has been studied for decades, yielding speculative and often inconsistent results since the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8630451ed38372095c740185fa3f6171
https://doi.org/10.3934/molsci.2021016
https://doi.org/10.3934/molsci.2021016
Autor:
Rebecca A. Wingert, Joseph M. Chambers
Publikováno v:
Kidney International. 97:1097-1099
Inherited and acquired disorders that affect proximal tubule endocytosis and lysosomal processing manifest with improper loss of solutes and proteins. The zebrafish pronephros is conserved with humans and is used to model numerous renal conditions, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e6a133daf4953c7d9cb5bfb982739f
https://doi.org/10.1016/j.kint.2020.02.014
https://doi.org/10.1016/j.kint.2020.02.014
Autor:
Nicole Handa, Bridgette E. Drummond, Rebecca A. Wingert, Amanda Addiego, Amanda N. Marra, Elvin E. Morales, Joseph M. Chambers
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Scientific Reports
Scientific Reports
Vertebrate kidneys contain nephron functional units where specialized epithelial cell types are organized into segments with discrete physiological roles. Many gaps remain in our understanding of how segment regions develop. Here, we report that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7222e6b684a27176af724a04485903
http://link.springer.com/article/10.1038/s41598-018-36061-4
http://link.springer.com/article/10.1038/s41598-018-36061-4