Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Joseph Longo"'
Autor:
James H. Schofield, Joseph Longo, Ryan D. Sheldon, Emma Albano, Abigail E. Ellis, Mark A. Hawk, Sean Murphy, Loan Duong, Sharif Rahmy, Xin Lu, Russell G. Jones, Zachary T. Schafer
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113984- (2024)
Summary: Targeting programmed cell death protein 1 (PD-1) is an important component of many immune checkpoint blockade (ICB) therapeutic approaches. However, ICB is not an efficacious strategy in a variety of cancer types, in part due to immunosuppre
Externí odkaz:
https://doaj.org/article/4c7f2836a59b4a5691fa9a3f93e654d9
Autor:
Gholson J. Lyon, Joseph Longo, Andrew Garcia, Fatima Inusa, Elaine Marchi, Daniel Shi, Max Dörfel, Thomas Arnesen, Rafael Aldabe, Scott Lyons, Melissa A. Nashat, David Bolton
Publikováno v:
PLoS ONE, Vol 19, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/53468b248e7c40a7bc6c2078e642e724
Autor:
Jenna E. van Leeuwen, Wail Ba-Alawi, Emily Branchard, Jennifer Cruickshank, Wiebke Schormann, Joseph Longo, Jennifer Silvester, Peter L. Gross, David W. Andrews, David W. Cescon, Benjamin Haibe-Kains, Linda Z. Penn, Deena M. A. Gendoo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Statins are promising for breast cancer therapy; dipyridamole can potentiate their effects, but is contraindicated in some cases. Here, the authors develop a pharmacogenomics pipeline to predict other compounds that potentiate statins, and validate t
Externí odkaz:
https://doaj.org/article/f57984f909454f0787ee786ab65589d9
Autor:
Gholson Lyon, Marall Vedaie, Travis Beisheim, Agnes Park, Elaine Marchi, Leah Gottlieb, Lois Starr, Katherine Sandomirsky, Hanyin Cheng, Isabelle Preddy, Marcellus Tseng, Quan Li, Kai Wang, Maureen Gavin, Karen Amble, Ronen Marmorstein, Ellen Herr-Israel, Randie Harpell, Melissa Nashat, Ning Ma, Nadjet Belbachir, Joseph Wu, Tzung-Chien Hsieh, Peter Krawitz, Alan Rope, Frederick Monsma, Josephine Wesely, Yu-Ren Chen, Christopher Hunter, Lauren Bauer, Tom Rusielewicz, Stephen Kneeland, Cat Lutz, Kathy Snow, Steve Murray, Andrea Gropman, Matthew Whitehead, Andrew Garcia, Fatima Inusa, Joseph Longo, Nicole Fleischer, David Bolton, Martin Reese, Yu Hu
Publikováno v:
Genetics in Medicine Open, Vol 1, Iss 1, Pp 100266- (2023)
Externí odkaz:
https://doaj.org/article/6ee2cf7739e74d029762a7fab02b9e5b
Autor:
Joseph Longo, Aleksandra A. Pandyra, Paweł Stachura, Mark D. Minden, Aaron D. Schimmer, Linda Z. Penn
Publikováno v:
Molecular Oncology, Vol 14, Iss 10, Pp 2533-2545 (2020)
Dipyridamole, an antiplatelet drug, has been shown to synergize with statins to induce cancer cell‐specific apoptosis. However, given the polypharmacology of dipyridamole, the mechanism by which it potentiates statin‐induced apoptosis remains unc
Externí odkaz:
https://doaj.org/article/cc9d4a89ea4c476590915dbcbbfed969
Autor:
Joseph Longo, Peter J. Mullen, Rosemary Yu, Jenna E. van Leeuwen, Mehdi Masoomian, Dixon T.S. Woon, Yuzhuo Wang, Eric X. Chen, Robert J. Hamilton, Joan M. Sweet, Theodorus H. van der Kwast, Neil E. Fleshner, Linda Z. Penn
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 119-130 (2019)
Objective: The statin family of cholesterol-lowering drugs has been shown to induce tumor-specific apoptosis by inhibiting the rate-limiting enzyme of the mevalonate (MVA) pathway, HMG-CoA reductase (HMGCR). Accumulating evidence suggests that statin
Externí odkaz:
https://doaj.org/article/f03d8eaff63e4e4990bc23cc62eb3734
Autor:
Corey Lourenco, Manpreet Kalkat, Kathleen E. Houlahan, Jason De Melo, Joseph Longo, Susan J. Done, Paul C. Boutros, Linda Z. Penn
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 7 (2019)
The potent MYC oncoprotein is deregulated in many human cancers, including breast carcinoma, and is associated with aggressive disease. To understand the mechanisms and vulnerabilities of MYC-driven breast cancer, we have generated an in vivo model t
Externí odkaz:
https://doaj.org/article/5c53bfc6b9444697a49291e7deac9981
Publikováno v:
Prostate Cancer and Prostatic Diseases. 25:650-656
Autor:
Gholson J. Lyon, Joseph Longo, Andrew Garcia, Fatima Inusa, Elaine Marchi, Daniel Shi, Max Dörfel, Thomas Arnesen, Rafael Aldabe, Scott Lyons, Melissa Nashat, David Bolton
Amino-terminal (Nt-) acetylation (NTA) is a common protein modification, affecting approximately 80% of all human proteins. The human essential X-linked gene,NAA10,encodes for the enzyme NAA10, which is the catalytic subunit in the N-terminal acetylt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::053d56a66db78f439160df844e66d525
https://doi.org/10.1101/2023.04.27.538618
https://doi.org/10.1101/2023.04.27.538618
Autor:
Linda Z. Penn, Benjamin Haibe-Kains, Wail Ba-Alawi, Peter J. Mullen, Jenna E. van Leeuwen, Joseph Longo, Rosemary Yu
Supplementary Figures S1-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c71cb2af12e29c1ec632c660bc8aeba
https://doi.org/10.1158/0008-5472.22410461.v1
https://doi.org/10.1158/0008-5472.22410461.v1