Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Joseph Locker"'
Autor:
Marta Melis, Rebecca Marino, Jianmin Tian, Carla Johnson, Rahil Sethi, Michael Oertel, Ira J. Fox, Joseph Locker
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 3, Pp 453-479 (2024)
Background & Aims: HNF4α, a master regulator of liver development and the mature hepatocyte phenotype, is down-regulated in chronic and inflammatory liver disease. We used contemporary transcriptomics and epigenomics to study the cause and effects o
Externí odkaz:
https://doaj.org/article/270e6dc5cdb04a1fb26e7c7fe9fb3567
Autor:
Sowmya Mekala, Ravi Rai, Samantha Loretta Reed, Bill Bowen, George K. Michalopoulos, Joseph Locker, Reben Raeman, Michael Oertel
Publikováno v:
Cells, Vol 13, Iss 7, p 649 (2024)
Background/Aim: Activin A is involved in the pathogenesis of human liver diseases, but its therapeutic targeting is not fully explored. Here, we tested the effect of novel, highly specific small-molecule-based activin A antagonists (NUCC-474/555) in
Externí odkaz:
https://doaj.org/article/645a524c9cd2403da680adf786157b77
Autor:
Tianyi Chen, George Dalton, Seh-Hoon Oh, Raquel Maeso-Diaz, Kuo Du, Rachel A. Meyers, Cynthia Guy, Manal F. Abdelmalek, Ricardo Henao, Paolo Guarnieri, Steven S. Pullen, Simon Gregory, Joseph Locker, J. Mark Brown, Anna Mae Diehl
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 4, Pp 949-970 (2023)
Background & Aims: Nonalcoholic steatohepatitis (NASH), a leading cause of cirrhosis, strongly associates with the metabolic syndrome, an insulin-resistant proinflammatory state that disrupts energy balance and promotes progressive liver degeneration
Externí odkaz:
https://doaj.org/article/9a1fec7762f04ba181df024b17ce1685
Publikováno v:
Hepatology Communications, Vol 3, Iss 8, Pp 1137-1150 (2019)
Because of their high regenerative potential, stem cells are an ideal resource for development of therapies that replace injured tissue mass and restore function in patients with end‐stage liver diseases. Using a rat model of bile duct ligation (BD
Externí odkaz:
https://doaj.org/article/91df9d2d8a494f7a89398a300dd2eddd
Autor:
Jun Liao, Keith A. Coffman, Joseph Locker, Quasar S. Padiath, Bruce Nmezi, Robyn A. Filipink, Jie Hu, Malini Sathanoori, Suneeta Madan‐Khetarpal, Marianne McGuire, Allison Schreiber, Rocio Moran, Neil Friedman, Lori Hoffner, Aleksandar Rajkovic, Svetlana A. Yatsenko, Urvashi Surti
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 9, Iss 4, Pp n/a-n/a (2021)
Abstract Background Benign hereditary chorea (BHC) is an autosomal dominant disorder characterized by early‐onset non‐progressive involuntary movements. Although NKX2‐1 mutations or deletions are the cause of BHC, some BHC families do not have
Externí odkaz:
https://doaj.org/article/6c3424bc2ff047dfb5cfdc13a434b42c
Publikováno v:
iScience, Vol 9, Iss , Pp 209-228 (2018)
Summary: The constitutive androstane receptor (CAR/Nr1i3) regulates detoxification of drugs and other xenobiotics by the liver. Binding of these compounds, activating ligands, causes CAR to translocate to the nucleus and stimulate genes of detoxifica
Externí odkaz:
https://doaj.org/article/8d3597a945cd4601b67aa5aca43d2768
Autor:
Willemieke M. Kouwenhoven, Lars von Oerthel, Maria Gruppilo, Jianmin Tian, Cindy M. R. J. Wagemans, Imke G. J. Houwers, Joseph Locker, Simone Mesman, Marten P. Smidt
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12663 (2021)
Nkx2.9 is a member of the NK homeobox family and resembles Nkx2.2 both in homology and expression pattern. However, while Nkx2.2 is required for development of serotonergic neurons, the role of Nkx2.9 in the mid-hindbrain region is still ill-defined.
Externí odkaz:
https://doaj.org/article/283aba92b0534e03b7fabca0de5e27a2
Autor:
Linwei Wu, Liem H Nguyen, Kejin Zhou, T Yvanka de Soysa, Lin Li, Jason B Miller, Jianmin Tian, Joseph Locker, Shuyuan Zhang, Gen Shinoda, Marc T Seligson, Lauren R Zeitels, Asha Acharya, Sam C Wang, Joshua T Mendell, Xiaoshun He, Jinsuke Nishino, Sean J Morrison, Daniel J Siegwart, George Q Daley, Ng Shyh-Chang, Hao Zhu
Publikováno v:
eLife, Vol 4 (2015)
The in vivo roles for even the most intensely studied microRNAs remain poorly defined. Here, analysis of mouse models revealed that let-7, a large and ancient microRNA family, performs tumor suppressive roles at the expense of regeneration. Too littl
Externí odkaz:
https://doaj.org/article/59dfff35532043c7a4356bb1fec531e8
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23234 (2011)
To study transcriptional regulation by distant enhancers, we devised a system of easily modified reporter plasmids for integration into single-copy targeting cassettes in clones of HuH7, a human hepatocellular carcinoma. The plasmid constructs tested
Externí odkaz:
https://doaj.org/article/1c97222d4bdd4e379070dd5369ad0af2
Autor:
Kelly Koral, Bharat Bhushan, Anne Orr, John Stoops, William C. Bowen, Matthew A. Copeland, Joseph Locker, Wendy M. Mars, George K. Michalopoulos
Publikováno v:
The American Journal of Pathology. 192:887-903
Activation of constitutive androstane receptor (CAR) transcription factor by xenobiotics promotes hepatocellular proliferation, promotes hypertrophy without liver injury, and induces drug metabolism genes. Previous work demonstrated that lymphocyte-s