Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Joseph Le Blevec"'
Autor:
Conception Nemecek, Joseph Le Blevec, Francois Audiau, Serge Mignani, Michel Barreau, Claude Gueremy, Patrick Jimonet
Publikováno v:
Synthetic Communications. 22:2769-2780
Convenient and regioselective syntheses of all three isomers of mononitro-6-trifluoromethoxy-benzothiazoles, starting from 2-amino-6-trifluoromethoxy-benzothiazole (riluzole) are described.
Autor:
Patrick Jimonet, François Audiau, Michel Barreau, Jean-Charles Blanchard, Alain Boireau, Yvette Bour, Marie-Annick Coléno, Adam Doble, Gilles Doerflinger, Claudine Do Huu, Marie-Hélène Donat, Jean Marie Duchesne, Pierre Ganil, Claude Guérémy, Eliane Honoré, Bernard Just, Roselyne Kerphirique, Sylvie Gontier, Philippe Hubert, Pierre M. Laduron, Joseph Le Blevec, Mireille Meunier, Jean-Marie Miquet, Conception Nemecek, Martine Pasquet, Odile Piot, Jeremy Pratt, Jean Rataud, Michel Reibaud, Jean-Marie Stutzmann, Serge Mignani
Publikováno v:
Journal of medicinal chemistry. 42(15)
Two series of analogues of riluzole, a blocker of excitatory amino acid mediated neurotransmission, have been synthesized: monosubstituted 2-benzothiazolamines and 3-substituted derivatives. Of all the compounds prepared in the first series, only 2-b