Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Joseph Larkin"'
Autor:
Vivian Valcarce, Lauren Stewart Stafford, Josef Neu, Leslie Parker, Valeria Vicuna, Tyler Cross, Olivia D'Agati, Sisse Diakite, Addison Haley, Jake Feigenbaum, Mahmoud Y. Al Mahmoud, Anjali Visvalingam, Nicole Cacho, Ivan Kosik, Jonathan W. Yewdell, Joseph Larkin
Publikováno v:
Frontiers in Nutrition, Vol 11 (2024)
BackgroundFacilitated by the inability to vaccinate, and an immature immune system, COVID-19 remains a leading cause of death among children. Vaccinated lactating mothers produce specific SARS-CoV-2 antibodies in their milk, capable of neutralizing t
Externí odkaz:
https://doaj.org/article/ef3eec508f164906bfd36f5d8b196787
Autor:
Caryn E. Plummer, Timothy Polk, Jatin Sharma, Sanghyo Sarah Bae, Olivia Barr, Amari Jones, Holly Kitchen, Michelle Wilhelmy, K. Devin, W. Clay Smith, Bryan D. Kolaczkowski, Joseph Larkin
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Equine recurrent uveitis (ERU) is a painful and debilitating autoimmune disease and represents the only spontaneous model of human recurrent uveitis (RU). Despite the efficacy of existing treatments, RU remains a leading cause of visual hand
Externí odkaz:
https://doaj.org/article/115c6235f83c49b2a22704b302d20713
Autor:
Jatin Sharma, Teresa D. Collins, Tracoyia Roach, Shiwangi Mishra, Brandon K. Lam, Zaynab Sidi Mohamed, Antia E. Veal, Timothy B. Polk, Amari Jones, Caleb Cornaby, Mohammed I. Haider, Leilani Zeumer-Spataro, Howard M. Johnson, Laurence M. Morel, Joseph Larkin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Autoimmune diseases are driven largely by a pathogenic cytokine milieu produced by aberrantly activated lymphocytes. Many cytokines, including interferon gamma (IFN-γ), utilize the JAK/STAT pathway for signal propagation. Suppressor of Cyto
Externí odkaz:
https://doaj.org/article/342a0706da1e4e82ad0f8fd96bbb0a38
Autor:
Antia E Veal, Joseph Larkin, Teresa D Collins, Brandon K Lam, Shiwangi Mishra, Jatin Sharma, Tracoyia Roach, Zaynab Sidi Mohamed, Timothy B Polk, Amari Jones, Caleb Cornaby, Mohammed I Haider, Leilani Zeumer-Spataro, Howard M Johnson, Laurence M Morel
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/972ff87c2ea14f9d84a3e912f4073547
Autor:
Winnie W Hui, Lisa E Emerson, Beata Clapp, Austin E Sheppe, Jatin Sharma, Johanna Del Castillo, Mark Ou, Gustavo H B Maegawa, Carol Hoffman, Joseph Larkin Iii, David W Pascual, Mariola J Ferraro
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009465 (2021)
Salmonella Typhimurium is a causative agent of nontyphoidal salmonellosis, for which there is a lack of a clinically approved vaccine in humans. As an intracellular pathogen, Salmonella impacts many cellular pathways. However, the intercellular commu
Externí odkaz:
https://doaj.org/article/32057af9e3e54a99bc58ca7cd36fb8ca
Autor:
Keshav Motwani, Leeana D. Peters, Willem H. Vliegen, Ahmed Gomaa El-sayed, Howard R. Seay, M. Cecilia Lopez, Henry V. Baker, Amanda L. Posgai, Maigan A. Brusko, Daniel J. Perry, Rhonda Bacher, Joseph Larkin, Michael J. Haller, Todd M. Brusko
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The human T lymphocyte compartment is highly dynamic over the course of a lifetime. Of the many changes, perhaps most notable is the transition from a predominantly naïve T cell state at birth to the acquisition of antigen-experienced memory and eff
Externí odkaz:
https://doaj.org/article/99b03748c4ef44f296bba8a3bcfeb3b1
Autor:
Jatin Sharma, Joseph Larkin
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The suppressor of cytokine signaling (SOCS) family of intracellular proteins has a vital role in the regulation of the immune system and resolution of inflammatory cascades. SOCS1, also called STAT-induced STAT inhibitor (SSI) or JAK-binding protein
Externí odkaz:
https://doaj.org/article/7bb24c8b38c2412585f48d0677af012b
Autor:
Howard M. Johnson, Joseph Larkin
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Externí odkaz:
https://doaj.org/article/b14c24b26bfa4c8d9a5219fb731f0d58
Publikováno v:
Mediators of Inflammation, Vol 2016 (2016)
Uveitis is a potentially sight-threatening disease characterized by repeated cycles of remission and recurrent inflammation. The JAK/STAT pathway regulates the differentiation of pathogenic Th1 and Th17 cells that mediate uveitis. A SOCS1 mimetic pep
Externí odkaz:
https://doaj.org/article/3228f2af3c6f46a3b189c8e583648fb8
Publikováno v:
Clinical and Developmental Immunology, Vol 2013 (2013)
Th17 and IL-17 play important roles in the clearance of extracellular bacterial and fungal infections. However, strong evidence also implicates the Th17 lineage in several autoimmune disorders including multiple sclerosis, psoriasis, rheumatoid arthr
Externí odkaz:
https://doaj.org/article/d0725a7792134a4e89d65292b8f88b88