Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Joseph L. Cantone"'
Autor:
Jeremy H. Toyn, Lorin A. Thompson, Kimberley A. Lentz, Jere E. Meredith, Catherine R. Burton, Sethu Sankaranararyanan, Valerie Guss, Tracey Hall, Lawrence G. Iben, Carol M. Krause, Rudy Krause, Xu-Alan Lin, Maria Pierdomenico, Craig Polson, Alan S. Robertson, R. Rex Denton, James E. Grace, John Morrison, Joseph Raybon, Xiaoliang Zhuo, Kimberly Snow, Ramesh Padmanabha, Michele Agler, Kim Esposito, David Harden, Margaret Prack, Sam Varma, Victoria Wong, Yingjie Zhu, Tatyana Zvyaga, Samuel Gerritz, Lawrence R. Marcin, Mendi A. Higgins, Jianliang Shi, Cong Wei, Joseph L. Cantone, Dieter M. Drexler, John E. Macor, Richard E. Olson, Michael K. Ahlijanian, Charles F. Albright
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2014 (2014)
Alzheimer’s disease is the most prevalent cause of dementia and is associated with accumulation of amyloid-β peptide (Aβ), particularly the 42-amino acid Aβ1-42, in the brain. Aβ1-42 levels can be decreased by γ-secretase modulators (GSM), whi
Externí odkaz:
https://doaj.org/article/1dce320132d4411583a19dcbfe2b54ae
Autor:
Tricia Protack, Sing-Yuen Sit, Dieter M. Drexler, Alicia Regueiro-Ren, Mark I. Cockett, Yan Chen, Jerry Jeffrey, Nicholas A. Meanwell, Joseph L. Cantone, Ira B. Dicker, Martin Gartland, Mark Krystal, Zeyu Lin, Brian McAuliffe
Publikováno v:
Antimicrobial Agents and Chemotherapy
HIV-1 maturation inhibitors (MIs) offer a novel mechanism of action and potential for use in HIV-1 treatment. Prior MIs displayed clinical efficacy but were associated with the emergence of resistance and some gastrointestinal tolerability events. Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ea10747ac645c2008b060f8062db2d
https://doi.org/10.1128/aac.01876-21
https://doi.org/10.1128/aac.01876-21
Autor:
T. Thanga Mariappan, Petia Shipkova, Joseph L. Cantone, Prabhakar Rajanna, Hong Shen, Jinping Gan, W. Griffith Humphreys, Shashyendra Singh Gautam, Dieter M. Drexler, Yueping Zhang, Vinay K. Holenarsipur, Punit Marathe
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 368:136-145
Plasma pyridoxic acid (PDA) and homovanillic acid (HVA) were recently identified as novel endogenous biomarkers of organic anion transporter (OAT) 1/3 function in monkeys. Consequently, this clinical study assessed the dynamic changes and utility of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90699d7ec3940e0a5942d9f499048583
https://doi.org/10.1124/jpet.118.252643
https://doi.org/10.1124/jpet.118.252643
Autor:
Joseph L. Cantone, Cong Wei, Michael K. Ahlijanian, Craig Polson, Valerie Guss, Jere E. Meredith, Dieter M. Drexler
Publikováno v:
Analytical Methods. 9:3477-3484
The research on neurodegenerative diseases is challenged by accurate disease diagnosis and evaluation of treatment response, thus there is a need for indicators at the molecular level, specifically biomarkers, that reliably provide disease diagnostic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4547f3d6229cf0d7aff659951eb5a83
https://doi.org/10.1039/c7ay00869d
https://doi.org/10.1039/c7ay00869d
Publikováno v:
Analytical Methods. 9:5219-5225
The human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) pandemic continues to adversely affect human health and life. Although several classes of HIV treatment drugs (antiretrovirals, ARVs) are available, there is a continuing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::313ab5b1f35a2d7bfc423cbf12f1a98a
https://doi.org/10.1039/c7ay01666b
https://doi.org/10.1039/c7ay01666b
Autor:
Xiaohua Stella Huang, Dieter M. Drexler, Xiaoliang Zhuo, John E. Leet, Benjamin M. Johnson, Kyle Parcella, Joseph L. Cantone, Matthew G. Soars, Kathleen W. Mosure, Kap-Sun Yeung, Kyle J. Eastman, Yingzi Wang, John F. Kadow
Publikováno v:
Drug Metabolism and Disposition. 44:1332-1340
During a medicinal chemistry campaign to identify inhibitors of the hepatitis C virus nonstructural protein 5B (RNA-dependent RNA polymerase), a bicyclo[1.1.1]pentane was introduced into the chemical scaffold to improve metabolic stability. The inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b7011e0ca07188f4028e1a99e2be88
https://doi.org/10.1124/dmd.115.069062
https://doi.org/10.1124/dmd.115.069062
Autor:
Joseph L. Cantone, Timothy V Olah, Colleen A. McNaney, Yulia Benitex, Dieter M. Drexler, Omar S. Barnaby
Publikováno v:
Bioanalysis. 7:2501-2513
The analysis of endogenous and exogenous analytes in biological matrices presents several challenges to the bioanalyst. These analytes are often present at low concentrations, typically in complex matrices, and may have physicochemical properties tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1d7dc1cfea47f1c6635bd957a5857f
https://doi.org/10.4155/bio.15.171
https://doi.org/10.4155/bio.15.171
Autor:
Ira B. Dicker, Dieter M. Drexler, Zheng Liu, Mark Krystal, Zeyu Lin, Hao Lu, Tian Yuan, Mark I. Cockett, Tricia Protack, Beata Nowicka-Sans, Max Lataillade, Hong Yang, Alicia Regueiro-Ren, Nicholas A. Meanwell, Joseph L. Cantone
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1005990 (2016)
PLoS Pathogens
PLoS Pathogens
HIV-1 maturation inhibitors (MIs) disrupt the final step in the HIV-1 protease-mediated cleavage of the Gag polyprotein between capsid p24 capsid (CA) and spacer peptide 1 (SP1), leading to the production of infectious virus. BMS-955176 is a second g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd71ed19186fde3cbd94df4bb85ba73
http://europepmc.org/articles/PMC5125710?pdf=render
http://europepmc.org/articles/PMC5125710?pdf=render
Publikováno v:
Journal of Neuroscience Methods. 180:255-260
An area of current research in Alzheimer's disease (AD) is the biosynthetic pathway of amyloid beta peptides (Abeta) via consecutive proteolytic cleavages of the amyloid beta precursor protein (APP) by BACE and gamma-secretase enzymes. APP is first c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc69c614d6cd124e4c147151b8a7e54a
https://doi.org/10.1016/j.jneumeth.2009.03.018
https://doi.org/10.1016/j.jneumeth.2009.03.018
Autor:
Bergstrom Carl P, Jeremy H. Toyn, Robert H. Grafstrom, Yang Michael G, Mcelhone Katharine E, Michael J. Ford, Cathy J. Kieras, Yang Cao, Dietmar A. Seiffert, Richard E. Olson, Lawrence G. Iben, Charles F. Albright, Joseph L. Cantone, Craig Polson, Maria Pierdomenico, Jason A. Corsa, Dieter M. Drexler, John E. Macor, Jere E. Meredith, Margi E. Goldstein, Lisa M. Sisk, Mark W. Thompson, Joanne J. Bronson, Arthur H. Roach, Catherine R. Burton, Tracey Fiedler, Carol M. Krause, Robert Zaczek, Yuval Blat, Donna M. Barten, Andrew M. Stern, Xu-Alan Lin
Publikováno v:
Journal of Biological Chemistry. 283:22992-23003
The amyloid-beta (Abeta) peptide, which likely plays a key role in Alzheimer disease, is derived from the amyloid-beta precursor protein (APP) through consecutive proteolytic cleavages by beta-site APP-cleaving enzyme and gamma-secretase. Unexpectedl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efba80ada17865ffd18096d0a9820ce3
https://doi.org/10.1074/jbc.m804175200
https://doi.org/10.1074/jbc.m804175200