Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Joseph L. Baker"'
Autor:
Jonasz B. Patkowski, Tobias Dahlberg, Himani Amin, Dharmender K. Gahlot, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Matthew S. Francis, Joseph L. Baker, Magnus Andersson, Tiago R. D. Costa
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Enteropathogenic bacteria use extracellular appendages, known as F-pili, to share plasmids carrying antibiotic resistance genes. Here, the authors show that F-pili are highly flexible but robust at the same time, and this is important for plasmid tra
Externí odkaz:
https://doaj.org/article/40e85687bf8846788a5af8d328f2c24c
Publikováno v:
Biophysical Journal. 121:2096-2106
Adhesion pili assembled by the chaperone-usher pathway are superelastic helical filaments on the surface of bacteria, optimized for attachment to target cells. Here, we investigate the biophysical function and structural interactions that stabilize P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9cf8bd8b017c7ca6fbeb23160070df
https://doi.org/10.1016/j.bpj.2022.04.036
https://doi.org/10.1016/j.bpj.2022.04.036
Autor:
Joshua R Greene, Kahla L Merrett, Alexanndra J Heyert, Lucas F Simmons, Camille M Migliori, Kristen C Vogt, Rebeca S Castro, Paul D Phillips, Joseph L Baker, Gerrick E Lindberg, David T Fox, Rico E Del Sesto, Andrew T Koppisch
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222211 (2019)
Choline geranate (also described as Choline And GEranic acid, or CAGE) has been developed as a novel biocompatible antiseptic material capable of penetrating skin and aiding the transdermal delivery of co-administered antibiotics. The antibacterial p
Externí odkaz:
https://doaj.org/article/29b3100e5b4e46f1a6a07be6dcd738c6
Publikováno v:
Structure
Bacterial adhesion pili are key virulence factors that mediate host-pathogen interactions in diverse epithelial environments. Deploying a multimodal approach, we probed the structural basis underpinning the biophysical properties of pili originating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad18330a0bc75c31db958f695454e800
https://europepmc.org/articles/PMC10164138/
https://europepmc.org/articles/PMC10164138/
Publikováno v:
Phys Chem Chem Phys
The deep eutectic solvent choline and geranate (CAGE) has shown promise in many therapeutic applications. CAGE facilitates drug delivery through unique modes of action making it an exciting therapeutic option. We examine the behavior of aqueous CAGE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9c215d6fde586b2f6af6012810d382
https://doi.org/10.1039/d2cp01530g
https://doi.org/10.1039/d2cp01530g
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2340
The nanomechanical characterization of several biological fibrils that are the result of protein aggregation via molecular dynamics simulation is nowadays feasible, and together with atomic force microscopy experiments has widened our understanding o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::18b4971dce7f837db0e2b0fdcc401c17
https://pubmed.ncbi.nlm.nih.gov/35167082
https://pubmed.ncbi.nlm.nih.gov/35167082
Publikováno v:
Methods in Molecular Biology ISBN: 9781071615454
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d7d9a62c20ec8a4ba1b9daa6a70b9ce
https://doi.org/10.1007/978-1-0716-1546-1_16
https://doi.org/10.1007/978-1-0716-1546-1_16
Publikováno v:
Liquids
Volume 1
Issue 1
Pages 4-59
Volume 1
Issue 1
Pages 4-59
The properties of alkanes are consequential for understanding many chemical processes in nature and industry. We use molecular dynamics simulations with the Amber force field GAFF2 to examine the structure of pure liquids at each respective normal bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c91c5352f416db77d5348924c9b057
Publikováno v:
Physical Chemistry Chemical Physics. 21:17950-17958
The A. aeolicus intrinsically disordered protein FlgM has four well-defined α-helices when bound to σ28, but in water FlgM undergoes a change in tertiary structure. In this work, we investigate the structure of FlgM in aqueous solutions of the ioni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f39015cc1eec98bbc46ee3489251e791
https://doi.org/10.1039/c9cp01882d
https://doi.org/10.1039/c9cp01882d
Publikováno v:
Proc Natl Acad Sci U S A
Escherichia coli express adhesion pili that mediate attachment to host cell surfaces that are exposed to body fluids in the urinary and gastrointestinal tracts. Pilin subunits are organized into helical polymers, with a tip adhesin for specific host
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb26f830c431ab0662f8c7511e64a0e
https://doi.org/10.1073/pnas.2023595118
https://doi.org/10.1073/pnas.2023595118