Zobrazeno 1 - 10
of 594
pro vyhledávání: '"Joseph L Witztum"'
Autor:
Peter Willeit, Julia Raschenberger, Emma E Heydon, Sotirios Tsimikas, Margot Haun, Agnes Mayr, Siegfried Weger, Joseph L Witztum, Adam S Butterworth, Johann Willeit, Florian Kronenberg, Stefan Kiechl
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112483 (2014)
Short telomeres have been linked to various age-related diseases. We aimed to assess the association of telomere length with incident type 2 diabetes mellitus (T2DM) in prospective cohort studies.Leucocyte relative telomere length (RTL) was measured
Externí odkaz:
https://doaj.org/article/3f8ba90c91b449c6840756509b15b353
Autor:
Kevin Yee-Bien Tse, Ayelet eGonen, John eSidney, Hui eOuyang, Joseph L Witztum, Alessandro eSette, Harley Y Tse, Klaus eLey
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
Background: Subsets of CD4+ T-cells have been proposed to serve differential roles in the development of atherosclerosis. Some T-cell types are atherogenic (T-helper type 1), while others are thought to be protective (regulatory T-cells). Lineage com
Externí odkaz:
https://doaj.org/article/ae5dc9697b3e49c0a98abb802771866c
Autor:
Soo-Ho Choi, Huiyong Yin, Amir Ravandi, Aaron Armando, Darren Dumlao, Jungsu Kim, Felicidad Almazan, Angela M Taylor, Coleen A McNamara, Sotirios Tsimikas, Edward A Dennis, Joseph L Witztum, Yury I Miller
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83145 (2013)
Oxidation of low-density lipoprotein (LDL) is one of the major causative mechanisms in the development of atherosclerosis. In previous studies, we showed that minimally oxidized LDL (mmLDL) induced inflammatory responses in macrophages, macropinocyto
Externí odkaz:
https://doaj.org/article/87ed55eeade74fe9a898dce0658d1287
Autor:
Xuchu Que, George F Widhopf, Shahzada Amir, Karsten Hartvigsen, Lotte F Hansen, Douglas Woelkers, Sotirios Tsimikas, Christoph J Binder, Thomas J Kipps, Joseph L Witztum
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65203 (2013)
The immunoglobulins expressed by chronic lymphocytic leukemia (CLL) B cells are highly restricted, suggesting they are selected for binding either self or foreign antigen. Of the immunoglobulin heavy-chain variable (IGHV) genes expressed in CLL, IGHV
Externí odkaz:
https://doaj.org/article/cc98243a866544aaaf1436e650601acd
Autor:
Joseph R Bishop, Maria Rita Passos-Bueno, Loren Fong, Kristin I Stanford, Jon C Gonzales, Erika Yeh, Stephen G Young, Andre Bensadoun, Joseph L Witztum, Jeffrey D Esko, Karen S Moulton
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13919 (2010)
Lipoprotein lipase (Lpl) acts on triglyceride-rich lipoproteins in the peripheral circulation, liberating free fatty acids for energy metabolism or storage. This essential enzyme is synthesized in parenchymal cells of adipose tissue, heart, and skele
Externí odkaz:
https://doaj.org/article/c6874896f581450091c9994b4deff930
Autor:
Adam Taleb, Peter Willeit, Shahzada Amir, Thomas Perkmann, Maria Ozsvar Kozma, Martin L. Watzenböck, Christoph J. Binder, Joseph L. Witztum, Sotirios Tsimikas
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 6, Pp 100391- (2023)
Immunoglobulin M (IgM) autoantibodies to oxidation-specific epitopes (OSEs) can be present at birth and protect against atherosclerosis in experimental models. This study sought to determine whether high titers of IgM titers to OSE (IgM OSE) are asso
Externí odkaz:
https://doaj.org/article/7e13b8f6a4a1409992df716051956c85
Autor:
Peng Zhao, Xiaoli Sun, Zhongji Liao, Hong Yu, Dan Li, Zeyang Shen, Christopher K. Glass, Joseph L. Witztum, Alan R. Saltiel
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Cardiovascular diseases, especially atherosclerosis and its complications, are a leading cause of death. Inhibition of the noncanonical IκB kinases TANK-binding kinase 1 and IKKε with amlexanox restores insulin sensitivity and glucose homeostasis i
Externí odkaz:
https://doaj.org/article/fc33a0413edb494fa587070ff0965270
Autor:
Cheng-Chieh Hsu, Baohai Shao, Jenny E. Kanter, Yi He, Tomas Vaisar, Joseph L. Witztum, Janet Snell-Bergeon, Gregory McInnes, Shannon Bruse, Omri Gottesman, Adam E. Mullick, Karin E. Bornfeldt
Publikováno v:
Nature Immunology. 24:408-411
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1b9f1b717601fe73bb0c91d91c60d09
https://doi.org/10.1038/s41590-023-01423-2
https://doi.org/10.1038/s41590-023-01423-2
Autor:
Elif A. Oral, Abhimanyu Garg, Joseph Tami, Eric A. Huang, Louis St.L. O'Dea, Hartmut Schmidt, Anatoly Tiulpakov, Ann Mertens, Veronica J. Alexander, Lynnetta Watts, Eunju Hurh, Joseph L. Witztum, Richard S. Geary, Sotirios Tsimikas
Publikováno v:
Journal of Clinical Lipidology. 16:833-849
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a511815ca92594eaecdb3be627b967ea
https://doi.org/10.1016/j.jacl.2022.08.008
https://doi.org/10.1016/j.jacl.2022.08.008
Autor:
Ewa Karwatowska-Prokopczuk, Jean-Claude Tardif, Daniel Gaudet, Christie M. Ballantyne, Michael D. Shapiro, Patrick M. Moriarty, Seth J. Baum, Eric St Amour, Veronica J. Alexander, Shuting Xia, James D. Otvos, Joseph L. Witztum, Sotirios Tsimikas
Publikováno v:
Journal of Clinical Lipidology. 16:617-625
Olezarsen is a hepatocyte-targeted, GalNAc-modified antisense oligonucleotide that decreases plasma levels of apolipoprotein C-III (apoC-III) and triglyceride-rich lipoproteins (TRLs).To define the effect of olezarsen on NMR-derived lipoprotein parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a1a318ab7ac2a72462312d99c8a5ad
https://doi.org/10.1016/j.jacl.2022.06.005
https://doi.org/10.1016/j.jacl.2022.06.005