Zobrazeno 1 - 10
of 794
pro vyhledávání: '"Joseph L Witztum"'
Autor:
Adam Taleb, Peter Willeit, Shahzada Amir, Thomas Perkmann, Maria Ozsvar Kozma, Martin L. Watzenböck, Christoph J. Binder, Joseph L. Witztum, Sotirios Tsimikas
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 6, Pp 100391- (2023)
Immunoglobulin M (IgM) autoantibodies to oxidation-specific epitopes (OSEs) can be present at birth and protect against atherosclerosis in experimental models. This study sought to determine whether high titers of IgM titers to OSE (IgM OSE) are asso
Externí odkaz:
https://doaj.org/article/7e13b8f6a4a1409992df716051956c85
Autor:
Peng Zhao, Xiaoli Sun, Zhongji Liao, Hong Yu, Dan Li, Zeyang Shen, Christopher K. Glass, Joseph L. Witztum, Alan R. Saltiel
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Cardiovascular diseases, especially atherosclerosis and its complications, are a leading cause of death. Inhibition of the noncanonical IκB kinases TANK-binding kinase 1 and IKKε with amlexanox restores insulin sensitivity and glucose homeostasis i
Externí odkaz:
https://doaj.org/article/fc33a0413edb494fa587070ff0965270
Autor:
Santica M. Marcovina, Nazanin Navabi, Serena Allen, Ayelet Gonen, Joseph L. Witztum, Sotirios Tsimikas
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 8, Pp 100239- (2022)
The study aims were to develop a new isoform-independent enzyme-linked immunoassay (ELISA) for the measurement of lipoprotein(a) [Lp(a)], validate its performance characteristics, and demonstrate its accuracy by comparison with the gold-standard ELIS
Externí odkaz:
https://doaj.org/article/6f168a3e03d846e9bed1e4e54bf094ec
Autor:
Prasad Srikakulapu, Tanyaporn Pattarabanjird, Aditi Upadhye, Sai Vineela Bontha, Victoria Osinski, Melissa A. Marshall, James Garmey, Justine Deroissart, Thomas A. Prohaska, Joseph L. Witztum, Christoph J. Binder, Nichol E. Holodick, Thomas L. Rothstein, Coleen A. McNamara
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunoglobulin M (IgM) to oxidation specific epitopes (OSE) are inversely associated with atherosclerosis in mice and humans. The B-1b subtype of B-1 cells secrete IgM to OSE, and unlike B-1a cells, are capable of long-lasting IgM memory. What attrib
Externí odkaz:
https://doaj.org/article/286501d5bfa64c20ac2f25408827ca76
Autor:
Bastian Ramms, Sohan Patel, Xiaoli Sun, Ariane R. Pessentheiner, G. Michelle Ducasa, Adam E. Mullick, Richard G. Lee, Rosanne M. Crooke, Sotirios Tsimikas, Joseph L. Witztum, Philip L.S.M. Gordts
Publikováno v:
JCI Insight, Vol 7, Iss 13 (2022)
Apolipoprotein C-III (apoC-III) is a critical regulator of triglyceride metabolism and correlates positively with hypertriglyceridemia and cardiovascular disease (CVD). It remains unclear if therapeutic apoC-III lowering reduces CVD risk and if the C
Externí odkaz:
https://doaj.org/article/d3c85ea05ac64087a50365d3f59dcc54
Autor:
Mete Civelek, Alan M. Fogelman, Catherine C. Hedrick, Aldons J. Lusis, Casey E. Romanoski, Joseph L. Witztum
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 4, Pp 100180- (2022)
Externí odkaz:
https://doaj.org/article/9195fa147a91497c9578e36c6dc5e092
Autor:
Ayelet Gonen, Xiaohong Yang, Calvin Yeang, Elena Alekseeva, Marlys Koschinsky, Joseph L. Witztum, Michael Boffa, Sotirios Tsimikas
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 9, Pp 1263-1270 (2020)
Lipoprotein (a) [Lp(a)] is a risk factor for CVD and a target of therapy, but Lp(a) measurements are not globally standardized. Commercially available assays generally use polyclonal antibodies that detect multiple sites within the kringle (K)IV2 rep
Externí odkaz:
https://doaj.org/article/d3ae9551f9854ddb99fa732ebadefc2a
Autor:
Michael B. Boffa, Tanya T. Marar, Calvin Yeang, Nicholas J. Viney, Shuting Xia, Joseph L. Witztum, Marlys L. Koschinsky, Sotirios Tsimikas
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 12, Pp 2082-2089 (2019)
It is postulated that lipoprotein (a) [Lp(a)] inhibits fibrinolysis, but this hypothesis has not been tested in humans due to the lack of specific Lp(a) lowering agents. Patients with elevated Lp(a) were randomized to antisense oligonucleotide [IONIS
Externí odkaz:
https://doaj.org/article/28dfa1e214734075affad1972af7235c
Autor:
Bastian Ramms, Sohan Patel, Chelsea Nora, Ariane R. Pessentheiner, Max W. Chang, Courtney R. Green, Gregory J. Golden, Patrick Secrest, Ronald M. Krauss, Christian M. Metallo, Christopher Benner, Veronica J. Alexander, Joseph L. Witztum, Sotirios Tsimikas, Jeffrey D. Esko, Philip L.S.M. Gordts
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 8, Pp 1379-1395 (2019)
Hypertriglyceridemia results from accumulation of triglyceride (TG)-rich lipoproteins (TRLs) in the circulation and is associated with increased CVD risk. ApoC-III is an apolipoprotein on TRLs and a prominent negative regulator of TG catabolism. We r
Externí odkaz:
https://doaj.org/article/79b2fc472cb54420abab601c33268491
Autor:
Audrey-Anne Després, BSc, Nicolas Perrot, MSc, Anthony Poulin, MD, Lionel Tastet, MSc, Mylène Shen, MSc, Hao Yu Chen, MSc, Raphaëlle Bourgeois, MSc, Mikaël Trottier, MD, Michel Tessier, MD, Jean Guimond, MD, Maxime Nadeau, TIM, James C. Engert, PhD, Sébastien Thériault, MD, MSc, Yohan Bossé, PhD, Joseph L. Witztum, MD, Patrick Couture, MD, Patrick Mathieu, MD, MSc, Marc R. Dweck, MD, Sotirios Tsimikas, MD, George Thanassoulis, MD, Philippe Pibarot, PhD, DVM, Marie-Annick Clavel, PhD, DVM, Benoit J. Arsenault, PhD
Publikováno v:
CJC Open, Vol 1, Iss 3, Pp 131-140 (2019)
Background: Lipoprotein(a) (Lp[a]) is the preferential lipoprotein carrier of oxidized phospholipids (OxPLs) and a well-established genetic risk factor for calcific aortic valve stenosis (CAVS). Whether Lp(a) predicts aortic valve microcalcification
Externí odkaz:
https://doaj.org/article/3ecc4f1cde6447aa92f6bf6f6a3e3623