Zobrazeno 1 - 10
of 412
pro vyhledávání: '"Joseph L Wiemels"'
Autor:
Katti Arroyo, Anahit Nargizyan, Francianne G Andrade, Swe Swe Myint, Sabrina Lu, Priyatama Pandey, Amy Yee, Adam J de Smith, Joseph L Wiemels
Publikováno v:
BioTechniques, Vol 72, Iss 4, Pp 121-133 (2022)
DNA methylation is a labile modification associated with gene expression control and environmental adaptations. High throughput, scalable and quantitative assessments of specific DNA methylation modifications in complex genomic regions for use in lar
Externí odkaz:
https://doaj.org/article/2ca2a00484b147d19bc0529fd8b56a68
Autor:
Shaobo Li, Charleston W K Chiang, Swe Swe Myint, Katti Arroyo, Tsz Fung Chan, Libby Morimoto, Catherine Metayer, Adam J de Smith, Kyle M Walsh, Joseph L Wiemels
Publikováno v:
PLoS Genetics, Vol 18, Iss 9, p e1010388 (2022)
BackgroundPilocytic astrocytoma (PA) is the most common pediatric brain tumor. PA has at least a 50% higher incidence in populations of European ancestry compared to other ancestral groups, which may be due in part to genetic differences.MethodsWe fi
Externí odkaz:
https://doaj.org/article/fd422ec2c6d84881bc7daf32d74b12c0
Autor:
Qianxi Feng, Eric Nickels, Ivo S Muskens, Adam J de Smith, W James Gauderman, Amy C Yee, Charite Ricker, Thomas Mack, Andrew D Leavitt, Lucy A Godley, Joseph L Wiemels
Publikováno v:
eLife, Vol 10 (2021)
Background: The role of race/ethnicity in genetic predisposition of early-onset cancers can be estimated by comparing family-based cancer concordance rates among ethnic groups. Methods: We used linked California health registries to evaluate the rela
Externí odkaz:
https://doaj.org/article/eb9c360e1b36468e8eba790ad15f7171
Autor:
Adam J de Smith, Kyle M Walsh, Helen M Hansen, Alyson A Endicott, John K Wiencke, Catherine Metayer, Joseph L Wiemels
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143343 (2015)
The extent to which heritable genetic variants can affect tumor development has yet to be fully elucidated. Tumor selection of single nucleotide polymorphism (SNP) risk alleles, a phenomenon called preferential allelic imbalance (PAI), has been demon
Externí odkaz:
https://doaj.org/article/7f4b0131b99d449aa252025e9064c37c
Autor:
Christofer Diakos, Yuanyuan Xiao, Shichun Zheng, Leo Kager, Michael Dworzak, Joseph L Wiemels
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87602 (2014)
E2A-PBX1 is expressed as a result of the t(1;19) chromosomal translocation in nearly 5% of cases of childhood acute lymphoblastic leukemia. The E2A-PBX1 chimeric transcription factor contains the N-terminal transactivation domain of E2A (TCF3) fused
Externí odkaz:
https://doaj.org/article/a463bd99c3af4c6c8fd629135e0a9512
Autor:
Shaobo Li, Natalia Spitz, Akram Ghantous, Sarina Abrishamcar, Brigitte Reimann, Irene Marques, Matt J. Silver, Sofía Aguilar-Lacasaña, Negusse Kitaba, Faisal I. Rezwan, Stefan Röder, Lea Sirignano, Johanna Tuhkanen, Giulia Mancano, Gemma C. Sharp, Catherine Metayer, Libby Morimoto, Dan J. Stein, Heather J. Zar, Rossella Alfano, Tim Nawrot, Congrong Wang, Eero Kajantie, Elina Keikkala, Sanna Mustaniemi, Justiina Ronkainen, Sylvain Sebert, Wnurinham Silva, Marja Vääräsmäki, Vincent W. V. Jaddoe, Robin M. Bernstein, Andrew M. Prentice, Marta Cosin-Tomas, Terence Dwyer, Siri Eldevik Håberg, Zdenko Herceg, Maria C. Magnus, Monica Cheng Munthe-Kaas, Christian M. Page, Maja Völker, Maria Gilles, Tabea Send, Stephanie Witt, Lea Zillich, Luigi Gagliardi, Lorenzo Richiardi, Darina Czamara, Katri Räikkönen, Lida Chatzi, Marina Vafeiadi, S. Hasan Arshad, Susan Ewart, Michelle Plusquin, Janine F. Felix, Sophie E. Moore, Martine Vrijheid, John W. Holloway, Wilfried Karmaus, Gunda Herberth, Ana Zenclussen, Fabian Streit, Jari Lahti, Anke Hüls, Thanh T. Hoang, Stephanie J. London, Joseph L. Wiemels
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterat
Externí odkaz:
https://doaj.org/article/a758b4bce3ff4982b903b79fec75b010
Autor:
Kevin Y Urayama, Anand P Chokkalingam, Catherine Metayer, Helen Hansen, Suzanne May, Patricia Ramsay, Joseph L Wiemels, John K Wiencke, Elizabeth Trachtenberg, Pamela Thompson, Yasushi Ishida, Paul Brennan, Kent W Jolly, Amanda M Termuhlen, Malcolm Taylor, Lisa F Barcellos, Patricia A Buffler
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72557 (2013)
The extended major histocompatibility complex (xMHC) is the most gene-dense region of the genome and harbors a disproportionately large number of genes involved in immune function. The postulated role of infection in the causation of childhood B-cell
Externí odkaz:
https://doaj.org/article/af2fe7bacf744cdda6e027a74fd707ff
Autor:
Melanie Joannides, Ashley N Mays, Anita R Mistry, Syed Khizer Hasan, Andreas Reiter, Joseph L Wiemels, Carolyn A Felix, Francesco Lo-Coco, Neil Osheroff, Ellen Solomon, David Grimwade
Publikováno v:
Mediterranean Journal of Hematology and Infectious Diseases, Vol 3, Iss 1, Pp e2011045-e2011045 (2011)
Balanced chromosomal translocations that generate chimeric oncoproteins are considered to be initiating lesions in the pathogenesis of acute myeloid leukemia. The most frequent is the t(15;17)(q22;q21), which fuses the PML and RARA genes, giving rise
Externí odkaz:
https://doaj.org/article/ec9e8c9f53b6491fb0f40175f05e8434
Autor:
Neil Osheroff, Ellen Solomon, Francesco Lo-Coco, Carolyn A Felix, Joseph L Wiemels, Andreas Reiter, Syed Khizer Hasan, Anita R Mistry, Ashley N Mays, Melanie Joannides, David Grimwade
Publikováno v:
Mediterranean Journal of Hematology and Infectious Diseases, Vol 3, Iss 1, Pp e2011045-e2011045 (2011)
Balanced chromosomal translocations that generate chimeric oncoproteins are considered to be initiating lesions in the pathogenesis of acute myeloid leukemia. The most frequent is the t(15;17)(q22;q21), which fuses the PML and RARA genes, giving rise
Externí odkaz:
https://doaj.org/article/9521ee5ed1a2493180e1845910df1f65
Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intake.
Autor:
Brock C Christensen, Karl T Kelsey, Shichun Zheng, E Andres Houseman, Carmen J Marsit, Margaret R Wrensch, Joseph L Wiemels, Heather H Nelson, Margaret R Karagas, Lawrence H Kushi, Marilyn L Kwan, John K Wiencke
Publikováno v:
PLoS Genetics, Vol 6, Iss 7, p e1001043 (2010)
Although tumor size and lymph node involvement are the current cornerstones of breast cancer prognosis, they have not been extensively explored in relation to tumor methylation attributes in conjunction with other tumor and patient dietary and hormon
Externí odkaz:
https://doaj.org/article/607d3de014c64f26b8fcbb09682fcba1