Zobrazeno 1 - 10
of 461
pro vyhledávání: '"Joseph L, DeRisi"'
Autor:
Victoria T. Chu, Alexandra Tsitsiklis, Eran Mick, Lilliam Ambroggio, Katrina L. Kalantar, Abigail Glascock, Christina M. Osborne, Brandie D. Wagner, Michael A. Matthay, Joseph L. DeRisi, Carolyn S. Calfee, Peter M. Mourani, Charles R. Langelier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Antimicrobial resistant lower respiratory tract infections are an increasing public health threat and an important cause of global mortality. The lung microbiome can influence susceptibility of respiratory tract infections and represents an
Externí odkaz:
https://doaj.org/article/a6e6c725bdd94596848389ca69371515
Autor:
Natasha Spottiswoode, Julia C. Haston, Natasha W. Hanners, Katherine Gruenberg, Annie Kim, Joseph L. DeRisi, Michael R. Wilson
Publikováno v:
Therapeutic Advances in Infectious Disease, Vol 11 (2024)
Granulomatous amebic encephalitis, caused by the free-living amebae Balamuthia mandrillaris or Acanthamoeba species, is a rare and deadly infectious syndrome with a current mortality rate of >90%. Much work remains to define the optimal treatment for
Externí odkaz:
https://doaj.org/article/e3bbcb4ebc2b42028cd1776a5500b9df
Autor:
Sara Sunshine, Andreas S. Puschnik, Joseph M. Replogle, Matthew T. Laurie, Jamin Liu, Beth Shoshana Zha, James K. Nuñez, Janie R. Byrum, Aidan H. McMorrow, Matthew B. Frieman, Juliane Winkler, Xiaojie Qiu, Oren S. Rosenberg, Manuel D. Leonetti, Chun Jimmie Ye, Jonathan S. Weissman, Joseph L. DeRisi, Marco Y. Hein
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Genomic and proteomic screens have identified numerous host factors of SARS-CoV-2, but efficient delineation of their molecular roles during infection remains a challenge. Here we use Perturb-seq, combining genetic perturbations with a singl
Externí odkaz:
https://doaj.org/article/117592a52159409a97218fac481cd781
Autor:
Natasha Spottiswoode, Samantha Hao, Estella Sanchez-Guerrero, Angela M. Detweiler, Honey Mekonen, Norma Neff, Henriette Macmillan, Brian S. Schwartz, Joanne Engel, Joseph L. DeRisi, Steven A. Miller, Charles R. Langelier
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Multidrug-resistant (MDR) Pseudomonas aeruginosa has been declared a serious threat by the United States Centers for Disease Control and Prevention. Here, we used whole genome sequencing (WGS) to investigate recurrent P. aeruginosa bloodstream infect
Externí odkaz:
https://doaj.org/article/2828eeef9fac42af85ebf115d386a7b2
Autor:
Natasha Spottiswoode, Douglas Pet, Annie Kim, Katherine Gruenberg, Maulik Shah, Amrutha Ramachandran, Matthew T. Laurie, Maham Zia, Camille Fouassier, Christine L. Boutros, Rufei Lu, Yueyuan Zhang, Venice Servellita, Andrew Bollen, Charles Y. Chiu, Michael R. Wilson, Liza Valdivia, Joseph L. DeRisi
Publikováno v:
Emerging Infectious Diseases, Vol 29, Iss 1, Pp 197-201 (2023)
A patient in California, USA, with rare and usually fatal Balamuthia mandrillaris granulomatous amebic encephalitis survived after receiving treatment with a regimen that included the repurposed drug nitroxoline. Nitroxoline, which is a quinolone typ
Externí odkaz:
https://doaj.org/article/5da61a78676945518ef5302991f98480
Prevalence of type-1 interferon autoantibodies in adults with non-COVID-19 acute respiratory failure
Autor:
Rajani Ghale, Natasha Spottiswoode, Mark S. Anderson, Anthea Mitchell, Grace Wang, Carolyn S. Calfee, Joseph L. DeRisi, Charles R. Langelier
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-4 (2022)
Abstract Auto-antibodies (Abs) to type I interferons (IFNs) are found in up to 25% of patients with severe COVID-19, and are implicated in disease pathogenesis. It has remained unknown, however, whether type I IFN auto-Abs are unique to COVID-19, or
Externí odkaz:
https://doaj.org/article/9d29d6413f03472e84cfd897a7ffe3f2
Autor:
Galina Popova, Hanna Retallack, Chang N Kim, Albert Wang, David Shin, Joseph L DeRisi, Tomasz Nowakowski
Publikováno v:
eLife, Vol 12 (2023)
Rubella virus is an important human pathogen that can cause neurological deficits in a developing fetus when contracted during pregnancy. Despite successful vaccination programs in the Americas and many developed countries, rubella remains endemic in
Externí odkaz:
https://doaj.org/article/4f8746bb20f94999af63565b7ec14524
Autor:
Aaron Bodansky, Chung-Yu Wang, Aditi Saxena, Anthea Mitchell, Andrew F. Kung, Saki Takahashi, Khamal Anglin, Beatrice Huang, Rebecca Hoh, Scott Lu, Sarah A. Goldberg, Justin Romero, Brandon Tran, Raushun Kirtikar, Halle Grebe, Matthew So, Bryan Greenhouse, Matthew S. Durstenfeld, Priscilla Y. Hsue, Joanna Hellmuth, J. Daniel Kelly, Jeffrey N. Martin, Mark S. Anderson, Steven G. Deeks, Timothy J. Henrich, Joseph L. DeRisi, Michael J. Peluso
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
Some individuals do not return to baseline health following SARS-CoV-2 infection, leading to a condition known as long COVID. The underlying pathophysiology of long COVID remains unknown. Given that autoantibodies have been found to play a role in se
Externí odkaz:
https://doaj.org/article/1714be604dc64b8c836e37862b1624a6
Autor:
Eran Mick, Alexandra Tsitsiklis, Natasha Spottiswoode, Saharai Caldera, Paula Hayakawa Serpa, Angela M. Detweiler, Norma Neff, Angela Oliveira Pisco, Lucy M. Li, Hanna Retallack, Kalani Ratnasiri, Kayla M. Williamson, Victoria Soesanto, Eric A. F. Simões, Christiana Smith, Lisa Abuogi, Amy Kistler, Brandie D. Wagner, Joseph L. DeRisi, Lilliam Ambroggio, Peter M. Mourani, Charles R. Langelier
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The difference between children and adults in response to SARS-CoV-2 infection is not clearly established. Here the authors use gene expression analysis of nasopharyngeal samples from children and adults and show a higher level of immune response in
Externí odkaz:
https://doaj.org/article/c9e006ab7ba94c9dbbc5609925764a1e
Autor:
Paula Hayakawa Serpa, Xianding Deng, Mazin Abdelghany, Emily Crawford, Katherine Malcolm, Saharai Caldera, Monica Fung, Aaron McGeever, Katrina L. Kalantar, Amy Lyden, Rajani Ghale, Thomas Deiss, Norma Neff, Steven A. Miller, Sarah B. Doernberg, Charles Y. Chiu, Joseph L. DeRisi, Carolyn S. Calfee, Charles R. Langelier
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-12 (2022)
Abstract Background Antimicrobial resistance (AMR) is rising at an alarming rate and complicating the management of infectious diseases including lower respiratory tract infections (LRTI). Metagenomic next-generation sequencing (mNGS) is a recently e
Externí odkaz:
https://doaj.org/article/0fb98aa80e5743e49c981617d04d8d51