Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Joseph Kulczyk"'
Autor:
Nika Rajabian, Izuagie Ikhapoh, Shahryar Shahini, Debanik Choudhury, Ramkumar Thiyagarajan, Aref Shahini, Joseph Kulczyk, Kendall Breed, Shilpashree Saha, Mohamed Alaa Mohamed, Susan B. Udin, Aimee Stablewski, Kenneth Seldeen, Bruce R. Troen, Kirkwood Personius, Stelios T. Andreadis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Aged myoblasts suffer from impaired glycolysis and insulin resistance, but increase methionine catabolism, possibly to meet energetic demands. Here, authors show that inhibiting methionine metabolism via NANOG reprogramming or MAT2A inhibition restor
Externí odkaz:
https://doaj.org/article/20d14dcf72624910a7c1176a420cedc0
Autor:
Kalyan Vydiam, Jennifer Peirick, Song Liu, Aimee Stablewski, Thy Nguyen, Yali Zhang, Debanik Choudhury, Tyler Santarelli, Joseph Kulczyk, Izuagie Attairu Ikhapoh, Kenneth Ladd Seldeen, Stelios T. Andreadis, Pedro Lei, Bruce Robert Troen, Jianmin Wang, Shahryar Shahini, Ramkumar Thiyagarajan, Nika Rajabian, Aref Shahini
Publikováno v:
Science Advances
Description
The embryonic factor NANOG reverses aging hallmarks and rejuvenates senescent skeletal muscle progenitors.
Senescence of myogenic progenitors impedes skeletal muscle regeneration. Here, we show that overexpression of the transcr
The embryonic factor NANOG reverses aging hallmarks and rejuvenates senescent skeletal muscle progenitors.
Senescence of myogenic progenitors impedes skeletal muscle regeneration. Here, we show that overexpression of the transcr